Memory and Resting-State Connectivity in Acute Transient Global Amnesia: A Case-Control fMRI Study.
The 5 matches
- [1] § Materials and Methods › Statistical Analysis ↔ analysis/functions.py, lines 129–219 · score 0.76 · Aligned Rank Transform, Post hoc, Shapiro, ART, ANOVA, scores
- [2] § Results › Functional MRI ↔ analysis/ICA.ipynb, lines 50–65 · score 0.73 · dorsal DMN, ventral DMN, right SN, voxel, ECN, ICA
- [3] § Materials and Methods › Neuropsychological Battery ↔ analysis/main_analysis.ipynb, lines 81–200 · score 0.58 · cued recall, free recall, anterograde memory, incidental, clap, Mnemosyne
- [4] § Materials and Methods › Statistical Analysis ↔ analysis/functions.py, lines 129–219 · score 0.58 · post hoc, Linear, predictors, variables, fitted, Model
- [5] § Results › Neuropsychological Results ↔ analysis/main_analysis.ipynb, lines 81–200 · score 0.54 · cued recall, free recall, Anterograde memory, incidental, AES, scores
Paper
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The authors' code
Python · 785 lines · 34 KB · no license · 2 matches
functions.py at commit c950a5a, no license · at the source
Overview
- ToNIC Toulouse NeuroImaging Center, UMR 1214, Universit. De Toulouse, INSERM, Paul Sabatier University (UT3) Toulouse France
- CNRS, Cerco Toulouse France
- Department of Neurology Neuroscience Centre, Toulouse‐Purpan University Hospital Toulouse Cedex France
- Department of Emergency Medicine University Hospital of Toulouse Toulouse France
- Laboratory of Epidemiology and Analyses in Public Health UMR 1295 Inserm, Toulouse University France
- Department of Neurolog Clinical Investigation Center, CIC1436, Toulouse University Hospital Toulouse France
- Department of Neuroradiology University Hospital of Toulouse Toulouse France
Abstract
Background and Objectives: Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their longitudinal evolution.
Methods: Prospective, single‐center case–control study of 20 patients with acute TGA and 20 age‐ and sex‐matched healthy controls. All participants completed neuropsychological testing and underwent structural and functional MRI at three time points: acute phase (< 24 h from onset), day 3, and 3 months. Primary outcomes were neuropsychological performance across episodic, semantic, and metamemory domains and resting‐state fMRI connectivity within the episodic memory network. Secondary outcomes were functional connectivity within the Default Mode (DMN), Executive (ECN), and Salience (SN) networks.
Results: A total of 40 participants were included (20 patients with TGA, mean age 65.5 years, 45% women; 20 controls, mean age 64.3 years, 45% women). In patients, median delay from symptoms' onset to MRI was 6.67 h. Neuropsychologically, patients showed profound multimodal anterograde amnesia during the acute phase, resolving by 3 months. This deficit was largely isolated, sparing semantic memory and metamemory. Structurally, small bilateral lesions were present in most patients. Functionally, acute hypoconnectivity was observed within the extended hippocampal system, particularly between parahippocampal and cingulate cortices, normalizing by 3 months. No consistent disruption was found in large‐scale networks (default mode, executive control, salience).
Interpretation: TGA is associated with transient, selective hypoconnectivity within the mesiotemporal–cingulate episodic memory network, aligning with previous reports and further precising the functional anatomy. The finding of a profound anterograde amnesia was replicated and its recovery timecourse was elucidated. Semantic memory and metamemory remain preserved, clarifying inconsistencies in prior reports. These findings suggest that TGA reflects a transient limbic dysconnectivity syndrome rather than a diffuse network disorder, reconciling structural lesions with clinical and functional data.
Reproduced under the paper's license (CC BY), from the paper cited above.
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EliasElOtmani/TGA
c950a5a092e4dcf92e29236d88503057babccfae, 13 February 2026Availability: 1 check, the latest on 29 September 2026: the link answers
- 29 September 2026: the link answers
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.ipynb_checkpoints/ — Jupyter, 72 lines, shown from its sourceICA-checkpoint.ipynb - analysis/
.ipynb_checkpoints/ — Jupyter, 75 lines, shown from its sourcedemographics-checkpoint. ipynb - analysis/
.ipynb_checkpoints/ — Jupyter, 1,330 lines, shown from its sourcefMRI_neuropsy_notebook-C opy1-checkpoint.ipynb - analysis/
.ipynb_checkpoints/ — Jupyter, 1,643 lines, shown from its sourcefMRI_neuropsy_notebook-C opy2-checkpoint.ipynb - analysis/
.ipynb_checkpoints/ — Jupyter, 2,067 lines, shown from its sourcefMRI_neuropsy_notebook-c heckpoint.ipynb - analysis/
.ipynb_checkpoints/ — Jupyter, 1,774 lines, shown from its sourcemain_analysis-checkpoint .ipynb - analysis/
.ipynb_checkpoints/ — Jupyter, 32 lines, shown from its sourcesMRI_analysis-checkpoint .ipynb - analysis/
ICA.ipynb — Jupyter, 73 lines, 1 match, shown from its source - analysis/
demographics.ipynb — Jupyter, 75 lines, shown from its source - analysis/
functions.py — Python, 785 lines, 2 matches, shown from its source - analysis/
main_analysis.ipynb — Jupyter, 1,774 lines, 2 matches, shown from its source - This repository has no license: its authors keep all rights. Read it at the source.
The paper's code and data availability statement is in the Data section.
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Data
No dataset and no data link were found in the paper.
Data Availability Statement
Light data such as neuropsychological data, 1st‐level preprocessed fMRI ROI‐to‐ROI data and python codes are available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, pages, dates, 11 authors, 3 keywords, 3 funders, 45 references.
Cite
This paper
El Otmani, E., Barbeau, E., Lemesle, B., Milongo‐Rigal, E., Fernandez, S., Charpentier, S., Albucher, J., Raposo, N., Bonneville, F., Péran, P., & Pariente, J. (2026). Memory and Resting-State Connectivity in Acute Transient Global Amnesia: A Case-Control fMRI Study. Annals of clinical and translational neurology, 10.1002/
BibTeX
@article{elotmani2026mem
author = {El Otmani, Elias and Barbeau, Emmanuel and Lemesle, Béatrice and Milongo‐Rigal, Emilie and Fernandez, Sophie and Charpentier, Sandrine and Albucher, Jean‐François and Raposo, Nicolas and Bonneville, Fabrice and Péran, Patrice and Pariente, Jérémie},
title = {{Memory and Resting-State Connectivity in Acute Transient Global Amnesia: A Case-Control fMRI Study}},
journal = {Annals of clinical and translational neurology},
year = {2026},
month = apr,
pages = {10.1002/
publisher = {Wiley},
issn = {2328-9503},
doi = {10.1002/
url = {https://
pmid = {41958247},
pmcid = {PMC13394162}
}
RIS
TY - JOUR
AU - El Otmani, Elias
AU - Barbeau, Emmanuel
AU - Lemesle, Béatrice
AU - Milongo‐Rigal, Emilie
AU - Fernandez, Sophie
AU - Charpentier, Sandrine
AU - Albucher, Jean‐François
AU - Raposo, Nicolas
AU - Bonneville, Fabrice
AU - Péran, Patrice
AU - Pariente, Jérémie
TI - Memory and Resting-State Connectivity in Acute Transient Global Amnesia: A Case-Control fMRI Study
T2 - Annals of clinical and translational neurology
J2 - Ann Clin Transl Neurol
PY - 2026
DA - 2026/
SP - 10.1002/
SN - 2328-9503
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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