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Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2<sup>-/-</sup> Mice.

Overview

Authors: Hongfang Wang1, Ziyao Wang2, Dongyue Zuo1, Zhaowen Su1, Bowen Song3, Jiamin Gao1, Yizhou Zhang1,4,5, Ruiting Zhao1, Linjie Sun1, Mengdi Li6, Yirui Fan6, Dandan Geng1,4,5, Lei Wang1,4,5,7
ORCID iDs: Hongfang Wang, Dandan Geng, Lei Wang
  1. Department of Human Anatomy, Hebei Medical University, Shijiazhuang, China
  2. Grade 2023, 5+3 Clinical Medicine, Hebei Medical University, Shijiazhuang, China
  3. Grade 2023, Clinical Medicine, Hebei Medical University, Shijiazhuang, China
  4. Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, China
  5. Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China
  6. Grade 2023, Clinical Medicine, Clinical College of Hebei Medical University, Shijiazhuang, China
  7. The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
Institutions: Hebei Medical University (China)
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany), article e24087
Dates: received 25 November 2025; accepted 17 September 2026; published online 27 September 2026; in print September 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/advs.202524087 · PMID 42801706 · PMCID PMC13616242 · OpenAlex W7214562555
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism)
Methods: Connectivity, Statistics, Machine learning, Evoked potentials
Keywords: IGF1, lncRNA Gm26550, learning and memory, Nrf2
Topic: Genomics, phytochemicals, and oxidative stress (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Natural Science Foundation of Hebei Province (H2023206164, H2023206258, H2024206135); National Natural Science Foundation of China (32471199, 82201731); Yanzhao Golden Platform Project of Hebei Province (HJYB202511); Key Laboratory of Neural and Vascular Biology of the Ministry of Education (NV20230003)
Citations: not cited yet (Europe PMC); 60 references in the paper
Research resources: RRID:CVCL_0063, RRID:CVCL_0321

Abstract

Nrf2 dysfunction is implicated in learning and memory deficits, but the involvement of non‐coding RNAs in Nrf2‐dependent cognitive regulation remains largely unexplored. Here, by analyzing the expression profiles of lncRNAs and mRNAs in the hippocampus of wild‐type (WT) and Nrf2 knockout (Nrf2−/−) mice, we identified a decreased expression of lncRNA Gm26550 in Nrf2−/− mice. Overexpression of Gm26550 enhances hippocampal neuronal synaptic plasticity and rescues learning and memory deficits in Nrf2−/− mice. Mechanistically, Nrf2 directly binds the promoter of Gm26550 to drive its transcriptional activation and upregulate its expression. Gm26550 elevates IGF1 abundance via two regulatory pathways to maintain cognitive function: first, it functionally counteracts miR‐26a‐5p‐mediated repression of IGF1; second, it interacts with the KH3/KH4 domain of KHSRP to block KHSRP‐triggered degradation of IGF1 mRNA. Collectively, our results reveal that Gm26550 maintains IGF1 expression and transcript stability through miR‐dependent antagonism and RBP sequestration, thereby governing learning and memory downstream of Nrf2. This work expands the understanding of the downstream molecular network controlled by Nrf2.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, pages, dates, 13 authors, 4 keywords, 4 funders, 59 references, 2 RRIDs.

Cite

This paper

Wang, H., Wang, Z., Zuo, D., Su, Z., Song, B., Gao, J., Zhang, Y., Zhao, R., Sun, L., Li, M., Fan, Y., Geng, D., & Wang, L. (2026). Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2<sup>-/-</sup> Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e24087. https://doi.org/10.1002/advs.202524087

BibTeX

@article{wang2026gm26550,
author = {Wang, Hongfang and Wang, Ziyao and Zuo, Dongyue and Su, Zhaowen and Song, Bowen and Gao, Jiamin and Zhang, Yizhou and Zhao, Ruiting and Sun, Linjie and Li, Mengdi and Fan, Yirui and Geng, Dandan and Wang, Lei},
title = {{Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2<sup>-/-</sup> Mice}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = sep,
pages = {e24087},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/advs.202524087},
url = {https://doi.org/10.1002/advs.202524087},
pmid = {42801706},
pmcid = {PMC13616242}
}

RIS

TY - JOUR
AU - Wang, Hongfang
AU - Wang, Ziyao
AU - Zuo, Dongyue
AU - Su, Zhaowen
AU - Song, Bowen
AU - Gao, Jiamin
AU - Zhang, Yizhou
AU - Zhao, Ruiting
AU - Sun, Linjie
AU - Li, Mengdi
AU - Fan, Yirui
AU - Geng, Dandan
AU - Wang, Lei
TI - Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2<sup>-/-</sup> Mice
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/09/27
SP - e24087
SN - 2198-3844
PB - Wiley
DO - 10.1002/advs.202524087
UR - https://doi.org/10.1002/advs.202524087
LA - en
ER -

CSL-JSON

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