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Gut-Brain Axis Modulation by Short-Chain Fatty Acids Exerts Disease-Modifying Effects in a Murine Model of Drug-Resistant Epilepsy.

Overview

Authors: Akash A Bera1, Rossella Di Sapia1, Greta Volpedo2, Sneha Anand1, Eray Sahin3, Pasquale Baldassarre1, Francesca Buffelli1, Andrea Petretto4, Chiara Lavarello4, James D Mills5,6, Gabriele Cattaneo1, Ilaria Craparotta7, Eleonora Aronica5, Antonella Riva2,8, Pasquale Striano2,8, Annamaria Vezzani1, Teresa Ravizza1
  1. Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
  2. Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health, University of Genova, Genoa, Italy
  3. University Hospital Würzburg, Würzburg, Germany
  4. Core Facility for Omics Sciences, IRCCS Istituto Giannina Gaslini, Genova, Italy
  5. Department of (Neuro)Pathology, Amsterdam UMC Location University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands
  6. Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
  7. Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
  8. IRCCS Istituto Giannina Gaslini, Genova, Italy
Journal: Annals of neurology, volume 100, issue 3, pages 613-627
Dates: received 19 March 2026; accepted 2 June 2026; published online 20 June 2026; in print September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/ana.78283 · PMID 42322241 · PMCID PMC13495800 · OpenAlex W7165367429
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: EEG (modality), human (organism), mouse (organism), epilepsy (population), clinical / translational (subfield)
MeSH: Brain*, Brain-Gut Axis*, Drug Resistant Epilepsy*, Fatty Acids, Volatile*, Gastrointestinal Microbiome*, Animals, Disease Models, Animal, Electroencephalography, Male, Mice, Mice, Inbred C57BL, Status Epilepticus (* major topic)
Topic: Gut microbiota and health (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Citations: cited by 1 paper (Europe PMC); 54 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1002/ana.78283.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Wiley

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 12 MeSH terms, 54 references.

Cite

This paper

Bera, A. A., Sapia, R. D., Volpedo, G., Anand, S., Sahin, E., Baldassarre, P., Buffelli, F., Petretto, A., Lavarello, C., Mills, J. D., Cattaneo, G., Craparotta, I., Aronica, E., Riva, A., Striano, P., Vezzani, A., & Ravizza, T. (2026). Gut-Brain Axis Modulation by Short-Chain Fatty Acids Exerts Disease-Modifying Effects in a Murine Model of Drug-Resistant Epilepsy. Annals of neurology, 100(3), 613-627. https://doi.org/10.1002/ana.78283

BibTeX

@article{bera2026gut,
author = {Bera, Akash A and Sapia, Rossella Di and Volpedo, Greta and Anand, Sneha and Sahin, Eray and Baldassarre, Pasquale and Buffelli, Francesca and Petretto, Andrea and Lavarello, Chiara and Mills, James D and Cattaneo, Gabriele and Craparotta, Ilaria and Aronica, Eleonora and Riva, Antonella and Striano, Pasquale and Vezzani, Annamaria and Ravizza, Teresa},
title = {{Gut-Brain Axis Modulation by Short-Chain Fatty Acids Exerts Disease-Modifying Effects in a Murine Model of Drug-Resistant Epilepsy}},
journal = {Annals of neurology},
year = {2026},
month = jun,
volume = {100},
number = {3},
pages = {613--627},
publisher = {Wiley},
issn = {0364-5134},
doi = {10.1002/ana.78283},
url = {https://doi.org/10.1002/ana.78283},
pmid = {42322241},
pmcid = {PMC13495800}
}

RIS

TY - JOUR
AU - Bera, Akash A
AU - Sapia, Rossella Di
AU - Volpedo, Greta
AU - Anand, Sneha
AU - Sahin, Eray
AU - Baldassarre, Pasquale
AU - Buffelli, Francesca
AU - Petretto, Andrea
AU - Lavarello, Chiara
AU - Mills, James D
AU - Cattaneo, Gabriele
AU - Craparotta, Ilaria
AU - Aronica, Eleonora
AU - Riva, Antonella
AU - Striano, Pasquale
AU - Vezzani, Annamaria
AU - Ravizza, Teresa
TI - Gut-Brain Axis Modulation by Short-Chain Fatty Acids Exerts Disease-Modifying Effects in a Murine Model of Drug-Resistant Epilepsy
T2 - Annals of neurology
J2 - Ann Neurol
PY - 2026
DA - 2026/06/20
VL - 100
IS - 3
SP - 613
EP - 627
SN - 0364-5134
PB - Wiley
DO - 10.1002/ana.78283
UR - https://doi.org/10.1002/ana.78283
LA - en
ER -

CSL-JSON

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"container-title": "Annals of neurology",
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