Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis.
Overview
- Sussex Centre for Consciousness Science, University of Sussex Brighton UK
- Department of Clinical Neuroscience Brighton and Sussex Medical School, University of Sussex Brighton UK
- School of Psychology, University of Sussex Brighton UK
- Institute of Cognitive Neuroscience, University College London London UK
- Monash Centre for Consciousness and Contemplative Studies, Monash University Melbourne Victoria Australia
- Department of Psychology Royal Holloway, University of London Egham UK
- School of Media, Arts and Humanities, University of Sussex Brighton UK
- School of Engineering and Informatics, University of Sussex Brighton UK
Abstract
Individual differences in susceptibility to somatosensory false physiological feedback reflect variations in interoceptive processing, yet the underlying neural network mechanisms remain unclear. We analyzed resting‐state functional connectivity using graph theoretical approaches in 41 healthy adults who completed a somatosensory false feedback paradigm. Nine regions of interest were defined from previous activation analyses, and network topology metrics including local efficiency, clustering coefficient, centrality measures, and path length were calculated across multiple thresholds. Three distinct patterns of network organization predicted false feedback susceptibility. Individuals more susceptible to false feedback showed: (1) increased posterior insula eccentricity, indicating network peripheralization of this key interoceptive region; (2) consistent orbitofrontal cortex segregation across multiple metrics including increased path length and decreased centrality measures; and (3) cerebellar network reconfiguration with reduced local efficiency but increased betweenness centrality. Somatosensory false feedback susceptibility reflects specific alterations in functional network topology, particularly reduced integration of interoceptive regions (posterior insula) and emotional appraisal systems (orbitofrontal cortex). These findings support a network‐based model where interoceptive processing depends on efficient integration between visceral sensation, emotional evaluation, and cognitive control systems. Understanding these network properties may inform interventions targeting interoceptive awareness and emotional regulation.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data and to no code of its authors: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
Data Availability Statement
The data that support the findings of this study are openly available in Functional Network Organization Underlying Individual at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 1 November 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 7 keywords, 14 MeSH terms, 2 funders, 106 references.
Cite
This paper
Patchitt, J., Karapanagiotidis, T., Garfinkel, S. N., Miller, M., Tsakiris, M., Clark, A., & Critchley, H. D. (2026). Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis. Human brain mapping, 47(16), e70640. https://
BibTeX
@article{patchitt2026fun
author = {Patchitt, J. and Karapanagiotidis, T. and Garfinkel, S. N. and Miller, M. and Tsakiris, M. and Clark, A. and Critchley, H. D.},
title = {{Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis}},
journal = {Human brain mapping},
year = {2026},
month = nov,
volume = {47},
number = {16},
pages = {e70640},
publisher = {Wiley},
issn = {1065-9471},
doi = {10.1002/
url = {https://
pmid = {42963537},
pmcid = {PMC13722775}
}
RIS
TY - JOUR
AU - Patchitt, J.
AU - Karapanagiotidis, T.
AU - Garfinkel, S. N.
AU - Miller, M.
AU - Tsakiris, M.
AU - Clark, A.
AU - Critchley, H. D.
TI - Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis
T2 - Human brain mapping
J2 - Hum Brain Mapp
PY - 2026
DA - 2026/
VL - 47
IS - 16
SP - e70640
SN - 1065-9471
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1002/
"type": "article-journal",
"title": "Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis",
"container-title": "Human brain mapping",
"author": [
{
"family": "Patchitt",
"given": "J."
},
{
"family": "Karapanagiotidis",
"given": "T."
},
{
"family": "Garfinkel",
"given": "S. N."
},
{
"family": "Miller",
"given": "M."
},
{
"family": "Tsakiris",
"given": "M."
},
{
"family": "Clark",
"given": "A."
},
{
"family": "Critchley",
"given": "H. D."
}
],
"container-title-short":
"volume": "47",
"issue": "16",
"page": "e70640",
"DOI": "10.1002/
"PMID": "42963537",
"PMCID": "PMC13722775",
"ISSN": "1065-9471",
"publisher": "Wiley",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
11,
1
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1038/s41598-025-94971-6
- Somatosensory false feedback biases emotional ratings through interoceptive embodiment.Journal: Scientific reportsIn common: 8 references, 2 authors
- [2] doi:10.1016/j.heliyon.2023.e18307
- Insula neuroanatomical networks predict interoceptive awareness.Journal: HeliyonIn common: 13 references
- [3] doi:10.1016/j.nicl.2022.103139 [code]
- Altered brain network topology in children with auditory processing disorder: A resting-state multi-echo fMRI study.Journal: NeuroImage. ClinicalIn common: 17 references
- [4] doi:10.1038/s41398-024-02971-3
- General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation.Journal: Translational psychiatryIn common: 8 references, author H. D. Critchley
- [5] doi:10.7554/elife.92820 [code]
- Hemispheric divergence of interoceptive processing across psychiatric disorders.Journal: eLifeIn common: 10 references
- [6] doi:10.1162/netn_a_00323 [code]
- Controversies and progress on standardization of large-scale brain network nomenclature.Journal: Network neuroscience (Cambridge, Mass.)In common: 12 references
- [7] doi:10.1371/journal.pcbi.1012870
- Exploring the transmission of cognitive task information through optimal brain pathways.Journal: PLoS computational biologyIn common: 11 references
- [8] doi:10.1038/s41593-025-02087-x [code]
- Cortical and subcortical mapping of the human allostatic-interoceptive
system using 7 Tesla fMRI. Journal: Nature neuroscienceIn common: 9 references - [9] doi:10.1016/j.isci.2024.109586 [code]
- Attention to cardiac sensations enhances the heartbeat-evoked potential during exhalation.Journal: iScienceIn common: 8 references
- [10] doi:10.1038/s42003-024-07160-y [code]
- The brain's first "traffic map" through Unified Structural and Functional Connectivity (USFC) modeling.Journal: Communications biologyIn common: 10 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.
Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.