No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults.
Overview
- School of Psychology and Sports Science, Bangor University, Bangor, Gwynedd, UK
- Mental Health and Learning Disability Division, Ysbyty Gwynedd, Penrhosgarnedd, Bangor, UK
- Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
- Oxford Health NHS Foundation Trust, Oxford, UK
- Department of Pharmacology, University of Oxford, Oxford, UK
Abstract
Objective: Impulsivity is a transdiagnostic risk factor for numerous health morbidities and is strongly associated with early relapse and poor treatment outcomes in addictions and mood‐disorders. Lithium carbonate can be helpful in moderating the impulsive behaviors associated with mania, possibly mediated by reduced myo‐inositol activity following inhibition of the enzyme inositol monophosphatase (IMPase). We tested the hypothesis that impulsivity—as motor disinhibition, decisions without adequate information, and stronger preferences for small immediate rewards over larger later rewards—can be moderated by the IMPase inhibitor ebselen in healthy adult volunteers.
Methods: One hundred and thirty healthy adults completed a between‐subjects, double‐blind, placebo‐controlled protocol. Over 2 days, participants received a previously validated dose of 1800 mg of ebselen or placebo before completing tests of impulsivity and decision‐making.
Results: There were no substantive changes in any measure of impulsivity following treatment with ebselen compared with placebo. Neither was there any convincing evidence of stronger treatment effects in high‐trait impulsive participants compared with low‐trait participants.
Conclusion: These results fail to replicate findings that ebselen administration moderates validated measures of impulsivity in healthy adults, at least at doses shown to reduce myo‐inositol within the medial prefrontal cortex and produce changes in emotional processing and reward‐based learning.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
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Data Availability Statement
The data that support the findings of this study are openly available in “No moderation of impulsivity by myo‐inositol inhibition” at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 2, 28 September 2026
- Publisher: n/a → Wiley
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 4 keywords, 13 MeSH terms, 1 funder, 86 references.
Cite
This paper
John, M. P. G., Earnshaw, L., Shankar, N. G., Raja, J. S., Davies, T. J., Cowen, P. J., Sharp, T., Salmoiraghi, A., & Rogers, R. D. (2026). No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults. Human psychopharmacology, 41(3), e70040. https://
BibTeX
@article{john2026no,
author = {John, Matthew P G and Earnshaw, Luke and Shankar, Nikhil Gauri and Raja, Jawad Sultan and Davies, Timothy J and Cowen, Phillip J and Sharp, Trevor and Salmoiraghi, Alberto and Rogers, Robert D},
title = {{No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults}},
journal = {Human psychopharmacology},
year = {2026},
month = may,
volume = {41},
number = {3},
pages = {e70040},
publisher = {Wiley},
issn = {0885-6222},
doi = {10.1002/
url = {https://
pmid = {42015338},
pmcid = {PMC13100343}
}
RIS
TY - JOUR
AU - John, Matthew P G
AU - Earnshaw, Luke
AU - Shankar, Nikhil Gauri
AU - Raja, Jawad Sultan
AU - Davies, Timothy J
AU - Cowen, Phillip J
AU - Sharp, Trevor
AU - Salmoiraghi, Alberto
AU - Rogers, Robert D
TI - No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults
T2 - Human psychopharmacology
J2 - Hum Psychopharmacol
PY - 2026
DA - 2026/
VL - 41
IS - 3
SP - e70040
SN - 0885-6222
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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