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Orb2 RNA-binding activity promotes neural stem cell development and brain growth in Drosophila larvae.

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Paper

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The authors' code

Shell · 5 lines · 97 B · MIT

  1. #!/bin/bash
  2. set -e
  4. psql -v ON_ERROR_STOP=1 --username username --dbname postgres <<-EOSQL
  5. EOSQL

init-tables.sh, under MIT · at the source

Overview

Authors: Taylor Hailstock1,2, Joseph Buehler1,2,3, Beverly V. Robinson1,4,3, Timothy C.H. Low5, Yuqing Hua6, Temitope H. Adebambo1, Junhyung Ahn6, Jack Govaerts7, Todd A. Schoborg7, Howard D. Lipshitz5, Dorothy A. Lerit1,8,9
ORCID iDs: Taylor Hailstock, Junhyung Ahn, Dorothy A. Lerit
  1. Emory University School of Medicine, Atlanta, GA 30322, USA
  2. Biochemistry, Cell, and Developmental Biology Graduate Program, Emory University, Atlanta, GA 30322, USA
  3. These authors contributed equally
  4. Genetics and Molecular Biology Graduate Program, Emory University, Atlanta, GA 30322, USA
  5. Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada
  6. Emory College of Arts and Science, Emory University, Atlanta, GA 30322, USA
  7. Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
  8. Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
  9. Lead contact
Institutions: Emory University (United States); University of Toronto (Canada); University of Wyoming (United States); Winship Cancer Institute
Journal: Cell reports, volume 45, issue 7, article 117680
Dates: published online 10 July 2026; in print 28 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.celrep.2026.117680 · PMID 42430239 · PMCID PMC13487878 · OpenAlex W7167797332
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: human (organism), drosophila (organism)
Methods: Statistics, Evoked potentials, Connectivity, fMRI & imaging
Keywords: Neurodevelopment, Neural stem cell, Tumor suppressor, Microcephaly, Brain Growth, translational control, Models Of Human Disease, Cp: Molecular Biology, Cp: Neuroscience
MeSH: Brain*, Drosophila melanogaster*, Drosophila Proteins*, mRNA Cleavage and Polyadenylation Factors*, Neural Stem Cells*, Neurogenesis*, RNA-Binding Proteins*, Animals, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Developmental, Larva, Neurodevelopment, Proto-Oncogene Proteins c-myc, Transcription Factors (* major topic)
Topic: RNA Research and Splicing (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NIH HHS (P40 OD018537, P40 OD010949); NIGMS NIH HHS (K12 GM000680, R35 GM155195, P20 GM103432, T32 GM008367, R01 GM138544, R35 GM158404, T32 GM008490); National Institute of General Medical Sciences; NINDS NIH HHS (F31 NS134380); National Institute of Neurological Disorders and Stroke; NCI NIH HHS (P30 CA138292); Howard Hughes Medical Institute; American Cancer Society Inc; Canadian Institutes of Health Research
Citations: not cited yet (Europe PMC); 116 references in the paper
Research resources: Goat anti-rabbit IgG Alexa Fluor 568 RRID:AB_10563566, Goat anti-rat IgG Alexa Fluor 647 RRID:AB_141778, Goat anti-guinea pig IgG Alexa Fluor 568 RRID:AB_141954, Goat anti-rabbit IgG Alexa Fluor 488 RRID:AB_143165, Rabbit anti-GFP RRID:AB_1834147, Goat anti-mouse HRP RRID:AB_228307, Goat anti-rabbit HRP RRID:AB_2533967, Goat anti-mouse IgG Alexa Fluor 488 RRID:AB_2534069, Goat anti-mouse IgG Alexa Fluor 568 RRID:AB_2534072, Goat anti-guinea pig IgG Alexa Fluor 488 RRID:AB_2534117, Goat anti-mouse IgG Alexa Fluor 647 RRID:AB_2535804, Goat anti-rabbit IgG Alexa Fluor 647 RRID:AB_2535812, Goat anti-guinea pig IgG Alexa Fluor 647 RRID:AB_2535867, Mouse anti-Orb2 RRID:AB_2619565, Mouse anti-Orb2 RRID:AB_2619566, Rabbit anti-DCP-1 (Asp215) RRID:AB_2721060, Mouse anti-Myc RRID:AB_2753231, Rat anti-Miranda RRID:AB_2936368, Rabbit anti-phospho-Histone H3 (pH3) RRID:AB_310177, Mouse anti-Actin RRID:AB_528068, Mouse anti-Elav RRID:AB_528217, Mouse anti-Prospero RRID:AB_528440, Mouse anti-Repo RRID:AB_528448, 2P30CA138292–04 RRID:SCR_023534

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repositories

Its files are read in the Code ↔ Paper reader above.

Zenodo 20530959

License: MIT
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: “Data and code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: NumPy (23 files), imageio (22 files), scikit-image (22 files), Matplotlib (20 files), SciPy (9 files), pandas (2 files), seaborn (1 file)
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
27 files
At the source: doi.org/10.5281/zenodo.20530959

pearlryder/subcellular-distribution-pipeline

License: MIT
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 414b5507455e316cabf67a99f47811113e7c25ea, 2 October 2020
Languages: Jupyter (23), Shell (1), Python (1)
Size: 41 files, 25 scripts
Software Heritage: archived
Found in: the Zenodo archive record
Holds: README, license file, environment (docker-compose.yml, jupyter/Dockerfile, jupyter/requirements.txt), documentation, 17 notebooks
Not found: CITATION.cff, tests, continuous integration
Tools: NumPy (23 files), imageio (22 files), scikit-image (22 files), Matplotlib (20 files), SciPy (9 files), pandas (2 files), seaborn (1 file)
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
27 files
At the source: github.com/pearlryder/subcellular-distribution-pipeline/tree/v1.0.0

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 50 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1016/j.celrep.2026.117680.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: — → Cell Press
  • Authors: added Junhyung Ahn (0009-0006-1896-4993); removed Junhyung Ahn

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 9 keywords, 15 MeSH terms, 9 funders, 116 references, 24 RRIDs.

Cite

This paper

Hailstock, T., Buehler, J., Robinson, B. V., Low, T. C., Hua, Y., Adebambo, T. H., Ahn, J., Govaerts, J., Schoborg, T. A., Lipshitz, H. D., & Lerit, D. A. (2026). Orb2 RNA-binding activity promotes neural stem cell development and brain growth in Drosophila larvae. Cell reports, 45(7), 117680. https://doi.org/10.1016/j.celrep.2026.117680

BibTeX

@article{hailstock2026orb2,
author = {Hailstock, Taylor and Buehler, Joseph and Robinson, Beverly V. and Low, Timothy C.H. and Hua, Yuqing and Adebambo, Temitope H. and Ahn, Junhyung and Govaerts, Jack and Schoborg, Todd A. and Lipshitz, Howard D. and Lerit, Dorothy A.},
title = {{Orb2 RNA-binding activity promotes neural stem cell development and brain growth in Drosophila larvae}},
journal = {Cell reports},
year = {2026},
month = jul,
volume = {45},
number = {7},
pages = {117680},
publisher = {Cell Press},
issn = {2211-1247},
doi = {10.1016/j.celrep.2026.117680},
url = {https://doi.org/10.1016/j.celrep.2026.117680},
pmid = {42430239},
pmcid = {PMC13487878}
}

RIS

TY - JOUR
AU - Hailstock, Taylor
AU - Buehler, Joseph
AU - Robinson, Beverly V.
AU - Low, Timothy C.H.
AU - Hua, Yuqing
AU - Adebambo, Temitope H.
AU - Ahn, Junhyung
AU - Govaerts, Jack
AU - Schoborg, Todd A.
AU - Lipshitz, Howard D.
AU - Lerit, Dorothy A.
TI - Orb2 RNA-binding activity promotes neural stem cell development and brain growth in Drosophila larvae
T2 - Cell reports
J2 - Cell Rep
PY - 2026
DA - 2026/07/10
VL - 45
IS - 7
SP - 117680
SN - 2211-1247
PB - Cell Press
DO - 10.1016/j.celrep.2026.117680
UR - https://doi.org/10.1016/j.celrep.2026.117680
LA - en
ER -

CSL-JSON

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