OSCR

The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management.

Overview

Authors: Santiago Uribe-Cano1,2, Andreas H. Kottmann1,2,3
ORCID iDs: Andreas H. Kottmann
  1. Department of Molecular, Cellular and Biomedical Sciences, CUNY School of Medicine, City University of New York, New York, NY, USA
  2. City University of New York Graduate Center, Neuroscience Collaborative, New York, NY, USA
  3. City University of New York Graduate Center, Molecular, Cellular and Developmental Subprogram, New York, NY, USA
Institutions: The Graduate Center, CUNY (United States); City University of New York (United States)
Journal: iScience, volume 29, issue 5, article 115324
Dates: received 25 July 2025; accepted 26 February 2026; published online 1 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.115324 · PMID 42058902 · PMCID PMC13122704 · OpenAlex W7147496289
Open access: gold, a free copy (OpenAlex)
Status: code on request
Methods: Spectral & time-frequency, Connectivity, Statistics, Preprocessing, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: biological sciences, neuroscience
Topic: Receptor Mechanisms and Signaling (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NIH (T32GM136499, AG065682, U54MD017979)
Citations: cited by 1 paper (Europe PMC); 97 references in the paper
Research resources: RRID:AB_11205592, RRID:AB_2079751, MAB anti neuronal nuclei (NeuN) (1:100) RRID:AB_2298772, RRID:AB_916156

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.115324.

Versions

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Version 2, 28 September 2026

  • Authors: added Andreas H. Kottmann (0000-0002-5435-7502); removed Andreas H. Kottmann

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 2 authors, 2 keywords, 1 funder, 97 references, 4 RRIDs.

Cite

This paper

Uribe-Cano, S., & Kottmann, A. H. (2026). The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management. iScience, 29(5), 115324. https://doi.org/10.1016/j.isci.2026.115324

BibTeX

@article{uribecano2026gpcr,
author = {Uribe-Cano, Santiago and Kottmann, Andreas H.},
title = {{The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {5},
pages = {115324},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115324},
url = {https://doi.org/10.1016/j.isci.2026.115324},
pmid = {42058902},
pmcid = {PMC13122704}
}

RIS

TY - JOUR
AU - Uribe-Cano, Santiago
AU - Kottmann, Andreas H.
TI - The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/04/01
VL - 29
IS - 5
SP - 115324
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115324
UR - https://doi.org/10.1016/j.isci.2026.115324
LA - en
ER -

CSL-JSON

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"container-title-short": "iScience",
"volume": "29",
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"DOI": "10.1016/j.isci.2026.115324",
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"language": "en",
"issued": {
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