Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.
Overview
Abstract
Stimulus-specific adaptation is a key feature of sensory systems, where the repeated presentation of a stimulus results in diminishing neuronal responses specifically to that stimulus, but not to a different stimulus. Cortical neurons display varying degrees of stimulus-specific adaptation, with cortical circuits shaping the dynamics of these responses. Here, we use calcium imaging and optogenetic approaches to assess the contributions of SOM and PV neurons to stimulus-specific adaptation in the mouse auditory cortex. We find opposing and complementary effects of SOM and PV neurons on the adaptation of principal neurons which manifest as context-dependent SOM neuron-mediated enhancement and PV-neuron mediated suppression of responses that depend on the temporal repetition rate of the sounds. Our results suggest that SOM and PV neurons can engage in multiple operating regimes that exist in a continuum during sensory processing.
Reproduced under the paper's license (CC BY), from the paper cited above.
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• All data generated in this study are available in the article. • This study does not report original code. • Any additional information required to reanalyze the data reported in this study is available from the lead contact upon request.
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Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 3 keywords, 5 funders, 92 references, 7 RRIDs.
Cite
This paper
Bender, P. T., McCollum, M., Trate, E., Bainer, K., Ruby, R., Li, H., & Anderson, C. T. (2026). Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds. iScience, 29(5), 115536. https://
BibTeX
@article{bender2026conte
author = {Bender, Philip T.R. and McCollum, Mason and Trate, Emma and Bainer, Kaitlin and Ruby, Rayli and Li, Hui and Anderson, Charles T.},
title = {{Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds}},
journal = {iScience},
year = {2026},
month = mar,
volume = {29},
number = {5},
pages = {115536},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42058911},
pmcid = {PMC13122691}
}
RIS
TY - JOUR
AU - Bender, Philip T.R.
AU - McCollum, Mason
AU - Trate, Emma
AU - Bainer, Kaitlin
AU - Ruby, Rayli
AU - Li, Hui
AU - Anderson, Charles T.
TI - Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 5
SP - 115536
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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