OSCR

Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids.

Overview

Authors: Romane Gaston-Breton1, Amal Bouzid2, Ekaterina Antipushina3,4, Narciso Costa1, Balazs Sarkadi5, Agota Apati5, Rania Harati2, Maxim Sharaev3,4, Jean Armengaud6, Clémence Disdier1, Rifat Hamoudi2,3,7,8, Aloïse Mabondzo1
  1. Paris Saclay University, CEA, INRAE, DMTS, SPI, Neurovascular Research Unit & Therapeutic Innovation Laboratory, Gif-sur-Yvette 91190, France
  2. Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates
  3. BIMAI-Lab, Biomedically Informed Artificial Intelligence Laboratory, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates
  4. Skolkovo Institute of Science and Technology, Moscow, Russia
  5. Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest 1117, Hungary
  6. Université Paris-Saclay, CEA DMTS, INRAE, SPI, 30200 Bagnols-sur-Cèze, France
  7. Center of Excellence for Precision Medicine, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates
  8. Division of Surgery and Interventional Science, University College London, London NW3 2PF UK
Journal: iScience, volume 29, issue 5, article 115714
Dates: received 6 October 2025; accepted 9 April 2026; published online 11 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.115714 · PMID 42111172 · PMCID PMC13157167 · OpenAlex W7153621930
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism)
Methods: Statistics
Keywords: developmental neuroscience
Topic: Genetic Neurodegenerative Diseases (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Agence Nationale de la Recherche (ANR-21-CE17-0019); Russian Science Foundation (N\u00B025-71-30008)
Citations: not cited yet (Europe PMC); 66 references in the paper
Research resources: SOX2 RRID:AB_10562630, NeuN RRID:AB_2298772, Goat anti-mouse (Alexa Fluor 488) RRID:AB_2534088, Goat anti-rabbit (Alexa Fluor 594) RRID:AB_2534095, PAX6 RRID:AB_2716656, GLAST RRID:AB_2718749, MAP2 RRID:AB_3677657, GFAP RRID:AB_477010

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: Zenodo 17993221
  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.115714.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 1 keyword, 2 funders, 66 references, 8 RRIDs.

Cite

This paper

Gaston-Breton, R., Bouzid, A., Antipushina, E., Costa, N., Sarkadi, B., Apati, A., Harati, R., Sharaev, M., Armengaud, J., Disdier, C., Hamoudi, R., & Mabondzo, A. (2026). Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids. iScience, 29(5), 115714. https://doi.org/10.1016/j.isci.2026.115714

BibTeX

@article{gastonbreton2026female,
author = {Gaston-Breton, Romane and Bouzid, Amal and Antipushina, Ekaterina and Costa, Narciso and Sarkadi, Balazs and Apati, Agota and Harati, Rania and Sharaev, Maxim and Armengaud, Jean and Disdier, Clémence and Hamoudi, Rifat and Mabondzo, Aloïse},
title = {{Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {5},
pages = {115714},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115714},
url = {https://doi.org/10.1016/j.isci.2026.115714},
pmid = {42111172},
pmcid = {PMC13157167}
}

RIS

TY - JOUR
AU - Gaston-Breton, Romane
AU - Bouzid, Amal
AU - Antipushina, Ekaterina
AU - Costa, Narciso
AU - Sarkadi, Balazs
AU - Apati, Agota
AU - Harati, Rania
AU - Sharaev, Maxim
AU - Armengaud, Jean
AU - Disdier, Clémence
AU - Hamoudi, Rifat
AU - Mabondzo, Aloïse
TI - Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/04/11
VL - 29
IS - 5
SP - 115714
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115714
UR - https://doi.org/10.1016/j.isci.2026.115714
LA - en
ER -

CSL-JSON

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