OSCR

Whole brain fluorescence imaging in <i>Drosophila</i> reveals spreading depolarization and its initiation, propagation, and resilience dynamics.

Overview

Authors: Allison L. Harris1, Grace Crowe2, Ella Nelson2, Mohammad Al Mokbil2, Wolfgang Stein2
  1. Department of Physics, Illinois State University, Normal, IL 61790, USA
  2. School of Biological Sciences, Illinois State University, Normal, IL 61790, USA
Institutions: Illinois State University (United States)
Journal: iScience, volume 29, issue 7, article 116389
Dates: received 15 January 2026; accepted 4 May 2026; published online 18 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.116389 · PMID 42375524 · PMCID PMC13311176 · OpenAlex W7165182277
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), drosophila (organism)
Methods: Statistics, fMRI & imaging
Keywords: Biological sciences, Neuroscience, Techniques in neuroscience
Topic: Neurobiology and Insect Physiology Research (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: College of Arts and Sciences; Illinois State University; School of Biological Sciences; Bloomington Drosophila Stock Center (NIH P40OD018537)
Citations: not cited yet (Europe PMC); 60 references in the paper
Research resources: Spike2 RRID:SCR_000903, Fiji RRID:SCR_002285, SigmaPlot RRID:SCR_003210, Adobe Illustrator RRID:SCR_010279, CorelDraw X7 RRID:SCR_014235, Excel 365 RRID:SCR_016137

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1016/j.isci.2026.116389.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Wolfgang Stein (0000-0001-8876-7537); removed Wolfgang Stein

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 3 keywords, 4 funders, 60 references, 6 RRIDs.

Cite

This paper

Harris, A. L., Crowe, G., Nelson, E., Al Mokbil, M., & Stein, W. (2026). Whole brain fluorescence imaging in <i>Drosophila</i> reveals spreading depolarization and its initiation, propagation, and resilience dynamics. iScience, 29(7), 116389. https://doi.org/10.1016/j.isci.2026.116389

BibTeX

@article{harris2026whole,
author = {Harris, Allison L. and Crowe, Grace and Nelson, Ella and Al Mokbil, Mohammad and Stein, Wolfgang},
title = {{Whole brain fluorescence imaging in \<i\>Drosophila\</i\> reveals spreading depolarization and its initiation, propagation, and resilience dynamics}},
journal = {iScience},
year = {2026},
month = jun,
volume = {29},
number = {7},
pages = {116389},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116389},
url = {https://doi.org/10.1016/j.isci.2026.116389},
pmid = {42375524},
pmcid = {PMC13311176}
}

RIS

TY - JOUR
AU - Harris, Allison L.
AU - Crowe, Grace
AU - Nelson, Ella
AU - Al Mokbil, Mohammad
AU - Stein, Wolfgang
TI - Whole brain fluorescence imaging in <i>Drosophila</i> reveals spreading depolarization and its initiation, propagation, and resilience dynamics
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/06/18
VL - 29
IS - 7
SP - 116389
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116389
UR - https://doi.org/10.1016/j.isci.2026.116389
LA - en
ER -

CSL-JSON

{
"id": "10.1016/j.isci.2026.116389",
"type": "article-journal",
"title": "Whole brain fluorescence imaging in <i>Drosophila</i> reveals spreading depolarization and its initiation, propagation, and resilience dynamics",
"container-title": "iScience",
"author": [
{
"family": "Harris",
"given": "Allison L."
},
{
"family": "Crowe",
"given": "Grace"
},
{
"family": "Nelson",
"given": "Ella"
},
{
"family": "Al Mokbil",
"given": "Mohammad"
},
{
"family": "Stein",
"given": "Wolfgang"
}
],
"container-title-short": "iScience",
"volume": "29",
"issue": "7",
"page": "116389",
"DOI": "10.1016/j.isci.2026.116389",
"PMID": "42375524",
"PMCID": "PMC13311176",
"ISSN": "2589-0042",
"publisher": "Elsevier",
"URL": "https://doi.org/10.1016/j.isci.2026.116389",
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
18
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1002/epi.70252
Dual role of spreading depolarization in an epileptic focus.
Journal: Epilepsia
In common: 3 references
[2] doi:10.1371/journal.pcbi.1014177 [code]
Activity-dependent neuromodulation and calcium homeostasis cooperate to produce robust and modulable neuronal function.
Journal: PLoS computational biology
In common: 3 references
[3] doi:10.1073/pnas.2530340123
Persistent adaptation through dual-timescale regulation of ion channel properties.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: 3 references
[4] doi:10.1371/journal.pcbi.1014701 [code]
Computer models predict differential dendritic vulnerability with ischemia and spreading depression.
Journal: PLoS computational biology
In common: 2 references
[5] doi:10.1007/s10827-026-00936-7 [code]
When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties?
Journal: Journal of computational neuroscience
In common: 2 references
[6] doi:10.1002/advs.202510538 [code]
Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
In common: drosophila, 1 reference
[7] doi:10.1038/s41467-026-71629-z
Extracellular K<sup>+</sup> modulates the pore conformations of Cys-loop receptor anion channels.
Journal: Nature communications
In common: drosophila, 1 reference
[8] doi:10.1073/pnas.2605750123
Light- and temperature-sensitive seizures are regulated by spatially distinct cortex glial populations in the central nervous system.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: drosophila, 1 reference
[9] doi:10.1113/jp290394 [code]
Conflicting adaptations in an inhibitory feedback circuit.
Journal: The Journal of physiology
In common: drosophila, 1 reference
[10] doi:10.1038/s41467-026-72710-3 [code]
A modular multi-color fluorescence microscope for simultaneous tracking of cellular activity and behavior.
Journal: Nature communications
In common: drosophila, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.