Slow intrinsic oscillations in the ventrolateral preoptic nucleus.
Overview
- Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, France
- Neuroglial Interactions in Cerebral Physiology and Pathologies, CIRB, Collège de France, CNRS UMR 7241, INSERM U1050, PSL University, PSL-Neuro, Paris 75005, France
- Brain Plasticity Unit, ESPCI-Paris, PSL Research University, Paris 75005, France
Abstract
The ventrolateral preoptic nucleus (VLPO) promotes non-rapid eye movement (NREM) sleep. While VLPO neurons often display low-threshold spikes (LTSs), a feature that supports rhythmic activity, rhythmic bursting has never been reported in these neurons. Here, we report that ∼12% of VLPO neurons in a large ex vivo patch-clamp dataset exhibit spontaneous rhythmic bursting. This pattern occurred in putative sleep-promoting neurons (inhibited by noradrenaline, NA), and in wake-active neurons (excited by NA). Unsupervised clustering of 24 bursting neurons using burst parameters, electrophysiological, and morphological features revealed three groups: one putative sleep-promoting subtype and two wake-active subtypes with fast and slow bursting. Strikingly, membrane potential oscillations persisted in tetrodotoxin (TTX), indicating an intrinsic mechanism. Bursts of inhibitory inputs were also recorded on sleep-promoting neurons. These results suggest that intrinsic rhythmic bursting may propagate to the local network, with functional relevance for sleep regulation.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 1 keyword, 3 funders, 77 references.
Cite
This paper
Perrenoud, Q., Ribot, J., Geoffroy, H., Gallopin, T., Rouach, N., & Rancillac, A. (2026). Slow intrinsic oscillations in the ventrolateral preoptic nucleus. iScience, 29(7), 116477. https://
BibTeX
@article{perrenoud2026sl
author = {Perrenoud, Quentin and Ribot, Jérôme and Geoffroy, Hélène and Gallopin, Thierry and Rouach, Nathalie and Rancillac, Armelle},
title = {{Slow intrinsic oscillations in the ventrolateral preoptic nucleus}},
journal = {iScience},
year = {2026},
month = jul,
volume = {29},
number = {7},
pages = {116477},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42436973},
pmcid = {PMC13355658}
}
RIS
TY - JOUR
AU - Perrenoud, Quentin
AU - Ribot, Jérôme
AU - Geoffroy, Hélène
AU - Gallopin, Thierry
AU - Rouach, Nathalie
AU - Rancillac, Armelle
TI - Slow intrinsic oscillations in the ventrolateral preoptic nucleus
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 7
SP - 116477
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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