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A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion.

Overview

Authors: Santosh Kumar1, Young Jae Bahn1, Claire Gao1, Ji-Hyeon Lee1, Audrey Noguchi2, Valentina Baena3, Zulfeqhar A Syed3, Sungyoung Auh1, Andrew Lutas1, Michael J Krashes1, Sushil G Rane1
ORCID iDs: Santosh Kumar, Sushil G Rane
  1. Diabetes, Endocrinology and Obesity Branch, NIDDK, USA
  2. MATRICES Lab, NIBIB, USA
  3. Electron Microscopy Core, NHLBI, NIH, Bethesda, MD, USA
Institutions: National Institute of Diabetes and Digestive and Kidney Diseases (United States); National Institute of Biomedical Imaging and Bioengineering (United States); National Institutes of Health (United States); National Heart, Lung, and Blood Institute (United States)
Journal: Molecular metabolism, volume 108, article 102371
Dates: received 14 January 2026; accepted 10 April 2026; published online 21 April 2026; in print June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.molmet.2026.102371 · PMID 42025694 · PMCID PMC13158791 · OpenAlex W7155031208
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: optical imaging (calcium, voltage, 2-photon) (modality), mouse (organism)
Methods: Statistics, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: Neuronal circuit, Vagal sensory neurons, Pancreatic islet β-cells, Insulin secretion, Glucose sensing, Feeding behavior, Glucose homeostasis
MeSH: Glucose*, Insulin Secretion*, Insulin-Secreting Cells*, Vagus Nerve*, Animals, Insulin, Male, Mice, Mice, Inbred C57BL, Nodose Ganglion, Sensory Receptor Cells (* major topic)
Topic: Pancreatic function and diabetes (Surgery, Medicine), according to OpenAlex
Funding: National Heart Lung and Blood Institute; Temple University; National Institute of Diabetes and Digestive and Kidney Diseases (DK055107, DK075073, DK075087-06, DK075088, DK055105, DK075167); U.S. Department of Health and Human Services; National Institutes of Health
Citations: not cited yet (Europe PMC); 111 references in the paper
Research resources: Guinea pig anti-insulin RRID:AB_10013624, c-Fos Antibody (4) RRID:AB_2106783, Normal Donkey Serum RRID:AB_2337258, RRID:AB_2340621, RRID:AB_2340689, RRID:AB_2340854, RRID:AB_2492288, C57BL/6J RRID:IMSR_JAX:000664, RRID:IMSR_JAX:007906, RRID:IMSR_JAX:024708, B6(Cg)-Ins1tm1.1(cre)Thor/J (Ins1cre) RRID:IMSR_JAX:026801, RRID:IMSR_JAX:028533

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

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Data

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Read it in the paper: doi.org/10.1016/j.molmet.2026.102371.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 11 authors, 7 keywords, 11 MeSH terms, 5 funders, 106 references, 12 RRIDs.

Cite

This paper

Kumar, S., Bahn, Y. J., Gao, C., Lee, J.-H., Noguchi, A., Baena, V., Syed, Z. A., Auh, S., Lutas, A., Krashes, M. J., & Rane, S. G. (2026). A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion. Molecular metabolism, 108, 102371. https://doi.org/10.1016/j.molmet.2026.102371

BibTeX

@article{kumar2026distinct,
author = {Kumar, Santosh and Bahn, Young Jae and Gao, Claire and Lee, Ji-Hyeon and Noguchi, Audrey and Baena, Valentina and Syed, Zulfeqhar A and Auh, Sungyoung and Lutas, Andrew and Krashes, Michael J and Rane, Sushil G},
title = {{A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion}},
journal = {Molecular metabolism},
year = {2026},
month = apr,
volume = {108},
pages = {102371},
publisher = {Elsevier},
issn = {2212-8778},
doi = {10.1016/j.molmet.2026.102371},
url = {https://doi.org/10.1016/j.molmet.2026.102371},
pmid = {42025694},
pmcid = {PMC13158791}
}

RIS

TY - JOUR
AU - Kumar, Santosh
AU - Bahn, Young Jae
AU - Gao, Claire
AU - Lee, Ji-Hyeon
AU - Noguchi, Audrey
AU - Baena, Valentina
AU - Syed, Zulfeqhar A
AU - Auh, Sungyoung
AU - Lutas, Andrew
AU - Krashes, Michael J
AU - Rane, Sushil G
TI - A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion
T2 - Molecular metabolism
J2 - Mol Metab
PY - 2026
DA - 2026/04/21
VL - 108
SP - 102371
SN - 2212-8778
PB - Elsevier
DO - 10.1016/j.molmet.2026.102371
UR - https://doi.org/10.1016/j.molmet.2026.102371
LA - en
ER -

CSL-JSON

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