Checkpoint blockade-related CNS adverse events are characterized by neurotoxic T helper cells with sustained neuroantigen reactivity.

1. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China
2. Institute of Abdominal Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China
3. Fujian Provincial Key Laboratory of Immunotherapy for Cancer, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China
4. Department of Hepatobiliary and Pancreatic Surgery, National Regional Medical Center Binhai Campus of the First Affiliated Hospital, Fuiian Medical University, Fuzhou, China
5. Department of Clinical Laboratory, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China
6. State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
7. Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China
8. Department of Orthopedics and Spine Surgery, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China
9. Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China
10. Department of Clinical Laboratory & Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
11. Department of Medicine, Nuvance Health Danbury Hospital, Danbury, CT, USA
12. Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China
13. Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
14. XLifeSc, Ltd, Guangzhou, China
15. Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China
16. Department of Ophthalmology, Chinese PLA General Hospital Hainan Branch, Sanya, China
17. Department of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
18. Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China
19. Internal Medicine Department, Jacobi Medical Center, 1400 Pelham Play S, Bronx, NY, USA
20. Department of General Surgery, Hainan Hospital of People’s Liberation Army General Hospital, Sanya, China
21. Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University, Beijing, China
22. Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China
23. Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China
24. Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China
25. Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, TX, USA
26. National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
27. Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China
28. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China
29. Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China
30. Department of General Surgery, General Hospital of XinJiang Military Command, Urumqi, China
31. Department of Thoracic Surgery, The First People’s Hospital of Shangqiu City Affiliated to Xinxiang Medical University, Shangqiu, China
32. Department of Neurology of First Affiliated Hospital, Institute of Neuroscience, Fujian Medical University, Fuzhou, China

@article{ma2026checkpoint,
author = {Ma, Yifei and Zhang, Ao and Lin, Jiacai and Ding, Fadian and Wang, Xinjia and Wang, Weidong and Jian, Guangmin and Zhang, Jingyao and Zhu, Pengfei and Ma, Yue and Lv, Jun and Zheng, Hongjun and Li, Jin and Wu, Tong and Zeng, Jiling and Jiang, Yongluo and Xu, Yiwei and Lyu, Xiajie and Wang, Youlong and Li, Yiming and Liu, Nianqi and Zheng, Zong-Qing and Niu, Yu Si and Guo, Zhenyun and Fang, Ningnan and Jiang, Wei and Wang, Lihong and Chen, Jiahao and Yuan, Mengqin and Huang, Qi and Li, Jinjian and Lu, Jun and Chen, Bocen and Huang, Tong and He, Tingting and Zhong, Guanqing and Li, Rui and Liu, Haizhou and Weng, Shangeng},
title = {{Checkpoint blockade-related CNS adverse events are characterized by neurotoxic T helper cells with sustained neuroantigen reactivity}},
journal = {Cell reports. Medicine},
year = {2026},
month = apr,
volume = {7},
number = {4},
pages = {102700},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/j.xcrm.2026.102700},
url = {https://doi.org/10.1016/j.xcrm.2026.102700},
pmid = {42019481},
pmcid = {PMC13130656}
}

TY - JOUR
AU - Ma, Yifei
AU - Zhang, Ao
AU - Lin, Jiacai
AU - Ding, Fadian
AU - Wang, Xinjia
AU - Wang, Weidong
AU - Jian, Guangmin
AU - Zhang, Jingyao
AU - Zhu, Pengfei
AU - Ma, Yue
AU - Lv, Jun
AU - Zheng, Hongjun
AU - Li, Jin
AU - Wu, Tong
AU - Zeng, Jiling
AU - Jiang, Yongluo
AU - Xu, Yiwei
AU - Lyu, Xiajie
AU - Wang, Youlong
AU - Li, Yiming
AU - Liu, Nianqi
AU - Zheng, Zong-Qing
AU - Niu, Yu Si
AU - Guo, Zhenyun
AU - Fang, Ningnan
AU - Jiang, Wei
AU - Wang, Lihong
AU - Chen, Jiahao
AU - Yuan, Mengqin
AU - Huang, Qi
AU - Li, Jinjian
AU - Lu, Jun
AU - Chen, Bocen
AU - Huang, Tong
AU - He, Tingting
AU - Zhong, Guanqing
AU - Li, Rui
AU - Liu, Haizhou
AU - Weng, Shangeng
TI - Checkpoint blockade-related CNS adverse events are characterized by neurotoxic T helper cells with sustained neuroantigen reactivity
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/04/01
VL - 7
IS - 4
SP - 102700
SN - 2666-3791
PB - Elsevier
DO - 10.1016/j.xcrm.2026.102700
UR - https://doi.org/10.1016/j.xcrm.2026.102700
LA - en
ER -

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