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Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.

A correction to this paper has been published: the notice, 41966693, from Europe PMC.

Overview

Authors: Yijie Lai1,2, Yingying Zhang3, Yuhan Wang1,2, Linbin Wang3,4, Luling Dai5, Kuanghao Ye1,2, Xin Lv1,2, Fengting Wang1,2, Jinrong Zhang1,2, Yijie Zhao3, Kejia Hu1,2, Peng Huang1,2, Xiaoxiao Zhang1,2, Xian Qiu1,2, Yixin Pan1,2, Wei Liu1,2, Qimin Liu6, Chencheng Zhang7,8, Yiru Fang7,8, Zheng Ye9,10
and 7 other authorsTi-Fei Yuan9,10, Dianyou Li1,2, Ninfei Li11, Andres M. Lozano12,13, Valerie Voon3,4, Shikun Zhan1,2, Bomin Sun1,2
ORCID iDs: Yijie Lai, Xin Lv, Peng Huang
13 affiliations
  1. Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  3. Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, China
  4. Department of Psychiatry, University of Cambridge, Cambridge, UK
  5. Department of Psychiatry, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China
  6. Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA
  7. Clinical Neuroscience Center, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  8. Department of Neurosurgery, Clinical Neuroscience Center Comprehensive Epilepsy Unit, Ruijin Hospital, Shanghai Jiao Tong, University School of Medicine, Shanghai, China
  9. School of Psychology, Shanghai Jiao Tong University, Shanghai, China
  10. Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  11. Department of Neurology with Experimental Neurology, Movement Disorders and Neuromodulation Unit, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
  12. Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada
  13. Krembil Research Institute, University of Toronto, Toronto, ON, Canada
Institutions: Shanghai Jiao Tong University (China); Ruijin Hospital (China); Fudan University (China); University of Cambridge (United Kingdom); Sir Run Run Shaw Hospital (China); Zhejiang University (China); Boston University (United States); Shanghai Mental Health Center (China); Shanghai Key Laboratory of Psychotic Disorders (China); Humboldt-Universität zu Berlin (Germany); Freie Universität Berlin (Germany); Charité – Universitätsmedizin Berlin (Germany); University Health Network (Canada); University of Toronto (Canada); Krembil Research Institute (Canada)
Journal: Cell reports. Medicine, volume 7, issue 4, article 102711
Dates: received 1 July 2025; accepted 25 February 2026; published online 31 March 2026; in print April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.xcrm.2026.102711 · PMID 41923626 · PMCID PMC13130622 · OpenAlex W7144324646
Open access: gold, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: human (organism), depression (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics, Machine learning, Preprocessing, Connectivity, fMRI & imaging
Keywords: depression, deep brain stimulation, clinical trial, magnetic resonance imaging, functional connectivity
MeSH: Deep Brain Stimulation*, Depression*, Nucleus Accumbens*, Septal Nuclei*, Adult, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Middle Aged, Quality of Life, Treatment Outcome (* major topic)
Topic: Neurotransmitter Receptor Influence on Behavior (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: National Natural Science Foundation of China (82271515, 82401813); Fundamental Research Funds for the Central Universities (YG2025QNB35); Science and Technology Commission of Shanghai Municipality (20410712000); Medical Research Council Senior Clinical Fellowship (MR/W020408/1); Shanghai Jiao Tong University (2019015); Scientific and Technological Innovation Action Plan of Shanghai (KY20211478); Shanghai Municipal Science and Technology Major Project (2021SHZDZX 835)
Citations: not cited yet (Europe PMC); 54 references in the paper
Notices: A correction to this paper has been published (41966693, from Europe PMC)

Abstract

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Read it in the paper: doi.org/10.1016/j.xcrm.2026.102711.

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 27 authors, 5 keywords, 13 MeSH terms, 7 funders, 54 references, 1 integrity notice.

Cite

This paper

Lai, Y., Zhang, Y., Wang, Y., Wang, L., Dai, L., Ye, K., Lv, X., Wang, F., Zhang, J., Zhao, Y., Hu, K., Huang, P., Zhang, X., Qiu, X., Pan, Y., Liu, W., Liu, Q., Zhang, C., Fang, Y., . . . Sun, B. (2026). Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial. Cell reports. Medicine, 7(4), 102711. https://doi.org/10.1016/j.xcrm.2026.102711

BibTeX

@article{lai2026bed,
author = {Lai, Yijie and Zhang, Yingying and Wang, Yuhan and Wang, Linbin and Dai, Luling and Ye, Kuanghao and Lv, Xin and Wang, Fengting and Zhang, Jinrong and Zhao, Yijie and Hu, Kejia and Huang, Peng and Zhang, Xiaoxiao and Qiu, Xian and Pan, Yixin and Liu, Wei and Liu, Qimin and Zhang, Chencheng and Fang, Yiru and Ye, Zheng and Yuan, Ti-Fei and Li, Dianyou and Li, Ninfei and Lozano, Andres M. and Voon, Valerie and Zhan, Shikun and Sun, Bomin},
title = {{Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial}},
journal = {Cell reports. Medicine},
year = {2026},
month = mar,
volume = {7},
number = {4},
pages = {102711},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/j.xcrm.2026.102711},
url = {https://doi.org/10.1016/j.xcrm.2026.102711},
pmid = {41923626},
pmcid = {PMC13130622}
}

RIS

TY - JOUR
AU - Lai, Yijie
AU - Zhang, Yingying
AU - Wang, Yuhan
AU - Wang, Linbin
AU - Dai, Luling
AU - Ye, Kuanghao
AU - Lv, Xin
AU - Wang, Fengting
AU - Zhang, Jinrong
AU - Zhao, Yijie
AU - Hu, Kejia
AU - Huang, Peng
AU - Zhang, Xiaoxiao
AU - Qiu, Xian
AU - Pan, Yixin
AU - Liu, Wei
AU - Liu, Qimin
AU - Zhang, Chencheng
AU - Fang, Yiru
AU - Ye, Zheng
AU - Yuan, Ti-Fei
AU - Li, Dianyou
AU - Li, Ninfei
AU - Lozano, Andres M.
AU - Voon, Valerie
AU - Zhan, Shikun
AU - Sun, Bomin
TI - Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/03/31
VL - 7
IS - 4
SP - 102711
SN - 2666-3791
PB - Elsevier
DO - 10.1016/j.xcrm.2026.102711
UR - https://doi.org/10.1016/j.xcrm.2026.102711
LA - en
ER -

CSL-JSON

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