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Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning.

Overview

Authors: David Leuthold1, Nadia K Herold1, Jana Nerlich2, Kristina Bartmann3,4, Ilka Scharkin3, Stefan J Hallermann2, Nicole Schweiger1, Ellen Fritsche3,4,5, Tamara Tal1,6
ORCID iDs: David Leuthold, Nadia K Herold, Nicole Schweiger, Tamara Tal
  1. Department of Ecotoxicology, Helmholtz-Centre for Environmental Research − UFZ, Leipzig 04318, Germany
  2. Medical Faculty, Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig 04103, Germany
  3. IUF − Leibniz Research Institute for Environmental Medicine, Düsseldorf 40225, Germany
  4. DNTOX GmbH, Düsseldorf 40223, Germany
  5. Swiss Centre for Applied Human Toxicology, University of Basel, Basel 4056, Switzerland
  6. Medical Faculty, University of Leipzig, Leipzig 04103, Germany
Institutions: Helmholtz Centre for Environmental Research (Germany); Leipzig University (Germany); Leibniz Institute of Environmental Medicine (Germany); University of Basel (Switzerland); Swiss Centre for Applied Human Toxicology
Journal: Environmental health perspectives, volume 134, issue 4, pages 465-484
Dates: accepted 15 May 2025; published online 2 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1021/ehp.6c00394 · PMID 42564692 · PMCID PMC13445272 · OpenAlex W4410892798
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: human (organism), mouse (organism), zebrafish (organism)
Methods: Connectivity, Statistics, Machine learning, Single-unit activity, calcium imaging
MeSH: Behavior, Animal*, Learning*, Zebrafish*, Animals, Habituation, Psychophysiologic, Humans, Larva, Mice, Neurons, Phenotype (* major topic)
Topic: Zebrafish Biomedical Research Applications (Cell Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Helmholtz Association (NA); Horizon 2020 (101057014)
Citations: cited by 1 paper (Europe PMC); 157 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

figshare 26819914

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file, 0 scripts
Software Heritage: not checked
Found in: “Data Availability Statement”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source: doi.org/10.6084/m9.figshare.26819914

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1021/ehp.6c00394.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 10 MeSH terms, 2 funders, 142 references.

Cite

This paper

Leuthold, D., Herold, N. K., Nerlich, J., Bartmann, K., Scharkin, I., Hallermann, S. J., Schweiger, N., Fritsche, E., & Tal, T. (2026). Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning. Environmental health perspectives, 134(4), 465-484. https://doi.org/10.1021/ehp.6c00394

BibTeX

@article{leuthold2026multibehavioral,
author = {Leuthold, David and Herold, Nadia K and Nerlich, Jana and Bartmann, Kristina and Scharkin, Ilka and Hallermann, Stefan J and Schweiger, Nicole and Fritsche, Ellen and Tal, Tamara},
title = {{Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning}},
journal = {Environmental health perspectives},
year = {2026},
month = jun,
volume = {134},
number = {4},
pages = {465--484},
publisher = {American Chemical Society},
issn = {0091-6765},
doi = {10.1021/ehp.6c00394},
url = {https://doi.org/10.1021/ehp.6c00394},
pmid = {42564692},
pmcid = {PMC13445272}
}

RIS

TY - JOUR
AU - Leuthold, David
AU - Herold, Nadia K
AU - Nerlich, Jana
AU - Bartmann, Kristina
AU - Scharkin, Ilka
AU - Hallermann, Stefan J
AU - Schweiger, Nicole
AU - Fritsche, Ellen
AU - Tal, Tamara
TI - Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning
T2 - Environmental health perspectives
J2 - Environ Health Perspect
PY - 2026
DA - 2026/06/02
VL - 134
IS - 4
SP - 465
EP - 484
SN - 0091-6765
PB - American Chemical Society
DO - 10.1021/ehp.6c00394
UR - https://doi.org/10.1021/ehp.6c00394
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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