OSCR

Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression.

Overview

Authors: Ty Lees1,2, Jason N. Scott Jr1, Brian W. Boyle2,3, Shiba M. Esfand1, Samantha R. Linton1,2, Courtney Miller3, Mohan Li1, Sarah E. Woronko1, Rebecca Dunayev1, Mario Bogdanov1,2, Paula Bolton3, Shuang Li2,3, Robert C. Meisner3,4, Diego A. Pizzagalli1,2,5
ORCID iDs: Ty Lees, Mohan Li, Sarah E. Woronko, Mario Bogdanov, Diego A. Pizzagalli
  1. Center for Depression, Anxiety, and Stress Research, McLean Hospital,Belmont, MA 02478 USA
  2. Department of Psychiatry, Harvard Medical School,Boston, MA 02215 USA
  3. Psychiatric Neurotherapeutics Program, McLean Hospital,Belmont, MA 02478 USA
  4. Acute Psychiatric Service, Massachusetts General Hospital,Boston, MA 02114 USA
  5. Noel Drury, M.D. Institute for Translational Depression Discoveries, University of California Irvine,Irvine, CA 92617 USA
Institutions: McLean Hospital (United States); Harvard University (United States); Massachusetts General Hospital (United States); University of California, Irvine (United States)
Journal: Translational psychiatry, volume 16, issue 1, article 134
Dates: received 8 August 2025; accepted 20 February 2026; published online 6 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41398-026-03928-4 · PMID 41792112 · PMCID PMC12979716 · OpenAlex W7134059525
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: EEG (modality), human (organism), depression (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Preprocessing, fMRI & imaging, Physiology & signal measures
Keywords: Psychology, Depression, Neuroscience
MeSH: Antidepressive Agents*, Default Mode Network*, Depressive Disorder, Treatment-Resistant*, Electroencephalography*, Ketamine*, Adult, Female, Humans, Male, Middle Aged (* major topic)
Topic: Treatment of Major Depression (Pharmacology, Medicine), according to OpenAlex
Funding: Funding for this project was provided by an investigator-initiated contract from Millennium Pharmaceuticals (awarded to D.A.P)
Citations: not cited yet (Europe PMC); 87 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41398-026-03928-4.

Tracing map

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Data

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Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41398-026-03928-4.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 3 keywords, 10 MeSH terms, 1 funder, 84 references.

Cite

This paper

Lees, T., Scott, J. N., Boyle, B. W., Esfand, S. M., Linton, S. R., Miller, C., Li, M., Woronko, S. E., Dunayev, R., Bogdanov, M., Bolton, P., Li, S., Meisner, R. C., & Pizzagalli, D. A. (2026). Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression. Translational psychiatry, 16(1), 134. https://doi.org/10.1038/s41398-026-03928-4

BibTeX

@article{lees2026modulatory,
author = {Lees, Ty and Scott, Jason N. and Boyle, Brian W. and Esfand, Shiba M. and Linton, Samantha R. and Miller, Courtney and Li, Mohan and Woronko, Sarah E. and Dunayev, Rebecca and Bogdanov, Mario and Bolton, Paula and Li, Shuang and Meisner, Robert C. and Pizzagalli, Diego A.},
title = {{Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression}},
journal = {Translational psychiatry},
year = {2026},
month = mar,
volume = {16},
number = {1},
pages = {134},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/s41398-026-03928-4},
url = {https://doi.org/10.1038/s41398-026-03928-4},
pmid = {41792112},
pmcid = {PMC12979716}
}

RIS

TY - JOUR
AU - Lees, Ty
AU - Scott, Jason N.
AU - Boyle, Brian W.
AU - Esfand, Shiba M.
AU - Linton, Samantha R.
AU - Miller, Courtney
AU - Li, Mohan
AU - Woronko, Sarah E.
AU - Dunayev, Rebecca
AU - Bogdanov, Mario
AU - Bolton, Paula
AU - Li, Shuang
AU - Meisner, Robert C.
AU - Pizzagalli, Diego A.
TI - Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/03/06
VL - 16
IS - 1
SP - 134
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/s41398-026-03928-4
UR - https://doi.org/10.1038/s41398-026-03928-4
LA - en
ER -

CSL-JSON

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