OSCR

Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development.

Overview

Authors: Yousra Ben Zouari1, Onkar Joshi1,2, Adwait Salvi1,3, Sandra Kessler1,4, Sebastien Ducret1, Fiona Ross1,3, Sjoerd J B Holwerda1,5, Nathalie Vilain1, Soujanya Mamilla-Sanivaram1, Sebastien Smallwood1, Hubertus Kohler1, Michael B Stadler1,3,6, Maryline Minoux1,7, Filippo M Rijli1,3
ORCID iDs: Sandra Kessler, Fiona Ross, Michael B Stadler, Maryline Minoux, Filippo M Rijli
  1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
  2. Present Address: Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
  3. University of Basel, Basel, Switzerland
  4. Present Address: European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
  5. Present Address: Department of Clinical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands
  6. Swiss Institute of Bioinformatics (SIB), Basel, Switzerland
  7. Faculté de Chirurgie Dentaire, INSERM UMR 1121, Université de Strasbourg, Strasbourg, France
Institutions: Friedrich Miescher Institute (Switzerland); University of Copenhagen (Denmark); University of Basel (Switzerland); European Molecular Biology Laboratory (Germany); European Molecular Biology Laboratory (Germany); University Medical Center Utrecht (Netherlands); SIB Swiss Institute of Bioinformatics (Switzerland); Inserm (France); Université de Strasbourg (France)
Journal: Nature communications, volume 17, issue 1, article 6438
Dates: received 2 June 2025; accepted 1 May 2026; published online 14 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-73065-5 · PMID 42135326 · PMCID PMC13376775 · OpenAlex W7161170473
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism)
Methods: Connectivity, Spectral & time-frequency, Statistics, Preprocessing, fMRI & imaging, Smoothing, state filtering, decompositions
Keywords: Chromatin, Morphogenesis
MeSH: Chromatin*, Enhancer Elements, Genetic*, Neural Crest*, Polycomb-Group Proteins*, Skull*, Animals, Enhancer of Zeste Homolog 2 Protein, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, Promoter Regions, Genetic (* major topic)
Topic: Genomics and Chromatin Dynamics (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: European Regional Development Fund
Citations: not cited yet (Europe PMC); 92 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-73065-5.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Funding: added European Commission

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 2 keywords, 11 MeSH terms, 89 references.

Cite

This paper

Ben Zouari, Y., Joshi, O., Salvi, A., Kessler, S., Ducret, S., Ross, F., Holwerda, S. J. B., Vilain, N., Mamilla-Sanivaram, S., Smallwood, S., Kohler, H., Stadler, M. B., Minoux, M., & Rijli, F. M. (2026). Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development. Nature communications, 17(1), 6438. https://doi.org/10.1038/s41467-026-73065-5

BibTeX

@article{benzouari2026polycomb,
author = {Ben Zouari, Yousra and Joshi, Onkar and Salvi, Adwait and Kessler, Sandra and Ducret, Sebastien and Ross, Fiona and Holwerda, Sjoerd J B and Vilain, Nathalie and Mamilla-Sanivaram, Soujanya and Smallwood, Sebastien and Kohler, Hubertus and Stadler, Michael B and Minoux, Maryline and Rijli, Filippo M},
title = {{Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {6438},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-73065-5},
url = {https://doi.org/10.1038/s41467-026-73065-5},
pmid = {42135326},
pmcid = {PMC13376775}
}

RIS

TY - JOUR
AU - Ben Zouari, Yousra
AU - Joshi, Onkar
AU - Salvi, Adwait
AU - Kessler, Sandra
AU - Ducret, Sebastien
AU - Ross, Fiona
AU - Holwerda, Sjoerd J B
AU - Vilain, Nathalie
AU - Mamilla-Sanivaram, Soujanya
AU - Smallwood, Sebastien
AU - Kohler, Hubertus
AU - Stadler, Michael B
AU - Minoux, Maryline
AU - Rijli, Filippo M
TI - Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/05/14
VL - 17
IS - 1
SP - 6438
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-73065-5
UR - https://doi.org/10.1038/s41467-026-73065-5
LA - en
ER -

CSL-JSON

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