OSCR

Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring.

Overview

Authors: Yue Jiang1,2,3, Xiaoyu Wei1,2, Xianghu Liu4, Jun Zhou1,2, Muyi Han1, Anqi Zhao1, Hong Lv1,5,6, Yangqian Jiang1,5,6, Yayun Gu1,6,7, Cheng Wang1,2, Juncheng Dai1,2, Hongxia Ma1,2, Guangfu Jin1,2, Ran Huo1,6, Qiang Wang1, Xuejiang Guo1, Hongbing Shen1,2, Yuan Lin1,5,6, Yuanlin He1,4, Qigang Zhou4, Zhibin Hu1,2
ORCID iDs: Hong Lv, Cheng Wang, Juncheng Dai, Hongxia Ma, Guangfu Jin, Ran Huo, Xuejiang Guo, Hongbing Shen, Yuan Lin, Qigang Zhou, Zhibin Hu
  1. State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University,Nanjing, China
  2. Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University,Nanjing, China
  3. Innovation Center of Suzhou Nanjing Medical University,Suzhou, China
  4. State Key Laboratory of Reproductive Medicine, Department of Clinic Pharmacology, School of Pharmacy, Nanjing Medical University,Nanjing, China
  5. Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University,Nanjing, China
  6. State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University,Suzhou, China
  7. Reproductive Genetic Center, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University,Suzhou, China
Institutions: Nanjing Medical University (China)
Journal: Nature communications, volume 17, issue 1, article 7782
Dates: received 25 July 2025; accepted 12 June 2026; published online 20 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-74712-7 · PMID 42323302 · PMCID PMC13438690 · OpenAlex W7165376154
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism)
Methods: Statistics, Machine learning
Keywords: Neuroscience, Risk factors, Germline development
MeSH: Chorionic Gonadotropin*, DNA Methylation*, Reproductive Techniques, Assisted*, Animals, Epigenesis, Genetic, Female, Histone-Lysine N-Methyltransferase, Humans, Male, Mice, Neurodevelopment, Neurogenesis, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies (* major topic)
Topic: Epigenetics and DNA Methylation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82221005, U24A20664, 82495190); National Natural Science Foundation of China (82221005),National Key Research & Development (R&D) Program of China (2024YFC2706800); National Key Research & Development (R&D) Program of China (2025YFC2708001 and 2021YFA1101801)
Citations: not cited yet (Europe PMC); 69 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-74712-7.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 21 authors, 3 keywords, 15 MeSH terms, 3 funders, 68 references.

Cite

This paper

Jiang, Y., Wei, X., Liu, X., Zhou, J., Han, M., Zhao, A., Lv, H., Jiang, Y., Gu, Y., Wang, C., Dai, J., Ma, H., Jin, G., Huo, R., Wang, Q., Guo, X., Shen, H., Lin, Y., He, Y., . . . Hu, Z. (2026). Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring. Nature communications, 17(1), 7782. https://doi.org/10.1038/s41467-026-74712-7

BibTeX

@article{jiang2026trigger,
author = {Jiang, Yue and Wei, Xiaoyu and Liu, Xianghu and Zhou, Jun and Han, Muyi and Zhao, Anqi and Lv, Hong and Jiang, Yangqian and Gu, Yayun and Wang, Cheng and Dai, Juncheng and Ma, Hongxia and Jin, Guangfu and Huo, Ran and Wang, Qiang and Guo, Xuejiang and Shen, Hongbing and Lin, Yuan and He, Yuanlin and Zhou, Qigang and Hu, Zhibin},
title = {{Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {7782},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-74712-7},
url = {https://doi.org/10.1038/s41467-026-74712-7},
pmid = {42323302},
pmcid = {PMC13438690}
}

RIS

TY - JOUR
AU - Jiang, Yue
AU - Wei, Xiaoyu
AU - Liu, Xianghu
AU - Zhou, Jun
AU - Han, Muyi
AU - Zhao, Anqi
AU - Lv, Hong
AU - Jiang, Yangqian
AU - Gu, Yayun
AU - Wang, Cheng
AU - Dai, Juncheng
AU - Ma, Hongxia
AU - Jin, Guangfu
AU - Huo, Ran
AU - Wang, Qiang
AU - Guo, Xuejiang
AU - Shen, Hongbing
AU - Lin, Yuan
AU - He, Yuanlin
AU - Zhou, Qigang
AU - Hu, Zhibin
TI - Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/20
VL - 17
IS - 1
SP - 7782
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-74712-7
UR - https://doi.org/10.1038/s41467-026-74712-7
LA - en
ER -

CSL-JSON

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