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Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia.

Overview

Authors: Eugenia Radulescu1, Petra E. Vértes2, Shizhong Han1,3,4, Jennifer A. Erwin5, Apuã C. M. Paquola6,7, Thomas M. Hyde1,3,6, Joel E. Kleinman1,3, Tomoyo Sawada1,6, Edward T. Bullmore2,8, Daniel R. Weinberger1,3,4,6,9
ORCID iDs: Eugenia Radulescu, Petra E. Vértes, Shizhong Han, Jennifer A. Erwin, Thomas M. Hyde, Joel E. Kleinman, Tomoyo Sawada, Edward T. Bullmore, Daniel R. Weinberger
  1. Lieber Institute for Brain Development, Johns Hopkins Medical Campus,Baltimore, Maryland USA
  2. Department of Psychiatry, University of Cambridge Clinical School,Cambridge, UK
  3. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine,Baltimore, Maryland USA
  4. McKusick-Nathans Department of Genetic Medicine, Johns Hopkins School of Medicine,Baltimore, Maryland USA
  5. Aluco BioSciences, San Carlos, USA
  6. Department of Neurology, Johns Hopkins School of Medicine,Baltimore, Maryland USA
  7. Present Address: DataTecnica, NIA Center for Alzheimer’s and Related Dementias (CARD), NIH,Bethesda, USA
  8. Institute of Psychiatry, Psychology & Neuroscience (IoPPN) IoPPN, 16 De Crespigny Park,London, UK
  9. Department of Neuroscience, Johns Hopkins School of Medicine,Baltimore, Maryland USA
Institutions: Lieber Institute for Brain Development (United States); University of Cambridge (United Kingdom); Johns Hopkins University (United States); National Institutes of Health (United States); King's College London (United Kingdom)
Journal: Nature communications, volume 17, issue 1, article 8739
Dates: received 10 October 2025; accepted 22 June 2026; published online 16 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75470-2 · PMID 42463512 · PMCID PMC13494048 · OpenAlex W7168724269
Open access: gold, a free copy (OpenAlex)
Status: dead link
Categories: genetics / omics (modality), human (organism), schizophrenia / psychosis (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing, Spectral & time-frequency
Keywords: Network topology, Neuroscience
MeSH: Gene Regulatory Networks*, Neurons*, Oligodendroglia*, Schizophrenia*, Brain, Dorsolateral Prefrontal Cortex, Female, Gene Expression Profiling, Hippocampus, Humans, Induced Pluripotent Stem Cells, Male (* major topic)
Topic: Genetic Associations and Epidemiology (Genetics, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: MQ: Transforming Mental Health (MQF17_24); National Institute for Health Research (NIHR) (NIHR203312)
Citations: not cited yet (Europe PMC); 89 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

EugeniaRadulescu/Differentially-Connected-Genes-in

License: none: the authors keep all their rights
State: the link is dead, verified on 27 September 2026
Evidence: found in the paper
Software Heritage: not archived
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link is dead
  • 27 September 2026: the link is dead
At the source: github.com/EugeniaRadulescu/Differentially-Connected-Genes-in

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-75470-2.

Tracing map

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  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-75470-2.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 2 keywords, 12 MeSH terms, 2 funders, 80 references.

Cite

This paper

Radulescu, E., Vértes, P. E., Han, S., Erwin, J. A., Paquola, A. C. M., Hyde, T. M., Kleinman, J. E., Sawada, T., Bullmore, E. T., & Weinberger, D. R. (2026). Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia. Nature communications, 17(1), 8739. https://doi.org/10.1038/s41467-026-75470-2

BibTeX

@article{radulescu2026analysis,
author = {Radulescu, Eugenia and Vértes, Petra E. and Han, Shizhong and Erwin, Jennifer A. and Paquola, Apuã C. M. and Hyde, Thomas M. and Kleinman, Joel E. and Sawada, Tomoyo and Bullmore, Edward T. and Weinberger, Daniel R.},
title = {{Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8739},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75470-2},
url = {https://doi.org/10.1038/s41467-026-75470-2},
pmid = {42463512},
pmcid = {PMC13494048}
}

RIS

TY - JOUR
AU - Radulescu, Eugenia
AU - Vértes, Petra E.
AU - Han, Shizhong
AU - Erwin, Jennifer A.
AU - Paquola, Apuã C. M.
AU - Hyde, Thomas M.
AU - Kleinman, Joel E.
AU - Sawada, Tomoyo
AU - Bullmore, Edward T.
AU - Weinberger, Daniel R.
TI - Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/16
VL - 17
IS - 1
SP - 8739
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75470-2
UR - https://doi.org/10.1038/s41467-026-75470-2
LA - en
ER -

CSL-JSON

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