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The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate.

Overview

Authors: Ryan F. Leung1,2, Michael See1,3, Ankita M. George1, Patrick L. Barry1,2, Kyle A. France1, Natalie Charitakis1,2,3, Mirana Ramialison1,2,3,4, Maree C. Faux1,2,5, David D. Eisenstat1,2,6,7
ORCID iDs: Ryan F. Leung, Michael See, Patrick L. Barry, Kyle A. France, Natalie Charitakis, Mirana Ramialison, Maree C. Faux, David D. Eisenstat
  1. Stem Cell Medicine Department, Murdoch Children’s Research Institute,Parkville, VIC Australia
  2. Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne,Parkville, VIC Australia
  3. The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW Melbourne, Murdoch Children’s Research Institute,Parkville, VIC Australia
  4. Australian Regenerative Medicine Institute, System Biology Institute, Monash University,Clayton, VIC Australia
  5. Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne,Parkville, VIC Australia
  6. Children’s Cancer Centre, The Royal Children’s Hospital Melbourne,Parkville, VIC Australia
  7. Departments of Medical Genetics, Paediatrics, and Oncology, Faculty of Medicine and Dentistry, University of Alberta,Edmonton, AB Canada
Institutions: Murdoch Children's Research Institute (Australia); The University of Melbourne (Australia); Monash University (Australia); Royal Children's Hospital (Australia); University of Alberta (Canada)
Journal: Nature communications, volume 17, issue 1, article 9940
Dates: received 29 August 2025; accepted 3 August 2026; published online 20 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-76838-0 · PMID 42754574 · PMCID PMC13586391 · OpenAlex W4414581653
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.09.28.679022
Status: data only
Categories: genetics / omics (modality), mouse (organism)
Methods: Preprocessing, Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity
Keywords: Developmental neurogenesis, Cell fate and cell lineage
MeSH: Homeodomain Proteins*, Neurons*, Receptors, Notch*, Transcription Factors*, Animals, Cell Differentiation, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Mice, Neural Stem Cells, Neurodevelopment, Neurogenesis, Neuroglia, Signal Transduction, Telencephalon (* major topic)
Topic: Developmental Biology and Gene Regulation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: University of Melbourne (Children's Cancer Foundation and My Room Chair in Childhood Cancer); Novo Nordisk Fonden (NNF21CC0073729); National Heart Foundation of Australia (Future Leader Fellowship 107328); Human Frontier Science Program (HFSP) (RGP008/2024); National Health and Medical Research Council (Ideas Grant APP1180905); Royal Children's Hospital Foundation; Establishment Grant 2019-1193
Citations: not cited yet (Europe PMC); 66 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-76838-0.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 2 keywords, 15 MeSH terms, 6 funders, 65 references.

Cite

This paper

Leung, R. F., See, M., George, A. M., Barry, P. L., France, K. A., Charitakis, N., Ramialison, M., Faux, M. C., & Eisenstat, D. D. (2026). The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate. Nature communications, 17(1), 9940. https://doi.org/10.1038/s41467-026-76838-0

BibTeX

@article{leung2026dlx,
author = {Leung, Ryan F. and See, Michael and George, Ankita M. and Barry, Patrick L. and France, Kyle A. and Charitakis, Natalie and Ramialison, Mirana and Faux, Maree C. and Eisenstat, David D.},
title = {{The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate}},
journal = {Nature communications},
year = {2026},
month = aug,
volume = {17},
number = {1},
pages = {9940},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-76838-0},
url = {https://doi.org/10.1038/s41467-026-76838-0},
pmid = {42754574},
pmcid = {PMC13586391}
}

RIS

TY - JOUR
AU - Leung, Ryan F.
AU - See, Michael
AU - George, Ankita M.
AU - Barry, Patrick L.
AU - France, Kyle A.
AU - Charitakis, Natalie
AU - Ramialison, Mirana
AU - Faux, Maree C.
AU - Eisenstat, David D.
TI - The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/08/20
VL - 17
IS - 1
SP - 9940
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-76838-0
UR - https://doi.org/10.1038/s41467-026-76838-0
LA - en
ER -

CSL-JSON

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