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Simple input-output dependencies explain neuronal activity.

Code ↔ Paper

2 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 2 matches · all tie a paragraph to a whole file, not to given lines: weak matches, whose lines are not tinted
  1. [1] § Higher-order and time-delayed dependencies ↔ run_minimax_entropy.m, the whole file · a weak match · score 0.64 · mouse visual cortex, mouse hippocampus, complete models, maximum entropy models, responding, spontaneous
  2. [2] § Direct dependencies across systems and species ↔ run_minimax_entropy.m, the whole file · a weak match · score 0.52 · mouse visual cortex, complete models, responding, spontaneous, hippocampus, neuron

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

The paper is loaded when this pane is shown.

The authors' code

MATLAB · 18 lines · 635 B · no license · 2 matches

  1. % Example script to compute the complete maximum entropy model (that is,
  2. % the maximum entropy model with the minimum number of inputs needed to
  3. % capture all direct dependencies) for a single neuron
  4. % Load data:
  5. data = load('data_mouse_hippocampus.mat'); % Hippocampus
  6. % data = load('data_mouse_visual_responding.mat'); % Visual cortex (responding)
  7. % data = load('data_mouse_visual_spontaneous.mat'); % Visual cortex (spontaneous)
  8. % data = load('data_C_elegans.mat'); % C. elegans
  9. % Time-series data:
  10. X = data.X;
  11. % Neuron to analyze:
  12. y = 13;
  13. % Run greedy algorithm to find optimal inputs and complete model:
  14. minimax_entropy(X, y);

run_minimax_entropy.m at commit 43c18e3, no license · at the source

Overview

Authors: Christopher W Lynn1,2,3
  1. Department of Physics, Yale University, New Haven, CT USA
  2. Quantitative Biology Institute, Yale University, New Haven, CT USA
  3. Wu Tsai Institute, Yale University, New Haven, CT USA
Institutions: Yale University (United States)
Journal: Nature physics, volume 22, issue 7, pages 1152-1159
Dates: received 21 April 2025; accepted 20 April 2026; published online 18 May 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41567-026-03306-3 · PMID 42370308 · PMCID PMC13309188 · OpenAlex W7161583042
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Methods: Connectivity, Single-unit activity, calcium imaging
Keywords: Biological physics, Information theory and computation, Statistical physics, Computational biophysics
Topic: Neural dynamics and brain function (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: NIGMS NIH HHS (R35 GM160188); U.S. Department of Health & Human Services | National Institutes of Health (R35GM160188)
Citations: cited by 1 paper (Europe PMC); 70 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repository

Its files are read in the Code ↔ Paper reader above, with 2 matches between paragraphs and lines of code.

ChrisWLynn/Minimal_computation

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Commit: 43c18e3761c5f68914aeb059516d53ebe15af06d, 25 February 2026
Languages: MATLAB (4)
Size: 9 files, 4 scripts
Software Heritage: not archived
Found in: “Code availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers
  • 28 September 2026: the link answers
5 files

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41567-026-03306-3.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 4 scripts, each with its path and the digest of its content;
  • 2 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41567-026-03306-3.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Nature Portfolio

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 1 author, 4 keywords, 2 funders, 55 references.

Cite

This paper

Lynn, C. W. (2026). Simple input-output dependencies explain neuronal activity. Nature physics, 22(7), 1152-1159. https://doi.org/10.1038/s41567-026-03306-3

BibTeX

@article{lynn2026simple,
author = {Lynn, Christopher W},
title = {{Simple input-output dependencies explain neuronal activity}},
journal = {Nature physics},
year = {2026},
month = may,
volume = {22},
number = {7},
pages = {1152--1159},
publisher = {Nature Portfolio},
issn = {1745-2473},
doi = {10.1038/s41567-026-03306-3},
url = {https://doi.org/10.1038/s41567-026-03306-3},
pmid = {42370308},
pmcid = {PMC13309188}
}

RIS

TY - JOUR
AU - Lynn, Christopher W
TI - Simple input-output dependencies explain neuronal activity
T2 - Nature physics
J2 - Nat Phys
PY - 2026
DA - 2026/05/18
VL - 22
IS - 7
SP - 1152
EP - 1159
SN - 1745-2473
PB - Nature Portfolio
DO - 10.1038/s41567-026-03306-3
UR - https://doi.org/10.1038/s41567-026-03306-3
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41567-026-03306-3",
"type": "article-journal",
"title": "Simple input-output dependencies explain neuronal activity",
"container-title": "Nature physics",
"author": [
{
"family": "Lynn",
"given": "Christopher W"
}
],
"container-title-short": "Nat Phys",
"volume": "22",
"issue": "7",
"page": "1152-1159",
"DOI": "10.1038/s41567-026-03306-3",
"PMID": "42370308",
"PMCID": "PMC13309188",
"ISSN": "1745-2473",
"publisher": "Nature Portfolio",
"URL": "https://doi.org/10.1038/s41567-026-03306-3",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
18
]
]
}
}

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