OSCR

Mapping the genetic landscape across 14 psychiatric disorders.

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Code

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GenomicSEM/GenomicSEM

License: GPL-3.0
State: the link answers
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rdocumentation.org/packages/stats

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precimed/mixer

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josefin-werme/LAVA

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wouterpeyrot/CCGWAS

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cran.r-project.org/web/packages

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toppgene.cchmc.org

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nathanskene.github.io/ewce

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neurogenomics.github.io/magma_celltyping

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Tools found in the code: data.table, ggplot2, ggpubr, lavaan, Matplotlib, NumPy, pandas, psych, SciPy, tidyverse

Overview

Authors: Andrew D Grotzinger, Josefin Werme, Wouter J Peyrot, Oleksandr Frei, Christiaan de Leeuw, Lucy K Bicks, Qiuyu Guo, Michael P Margolis, Brandon J Coombes, Anthony Batzler, Vanessa Pazdernik, Joanna M Biernacka, Ole A Andreassen, Verneri Anttila, Anders D Børglum, Gerome Breen, Na Cai, Ditte Demontis, Howard J Edenberg, Stephen V Faraone
and 47 other authorsBarbara Franke, Michael J Gandal, Joel Gelernter, Alexander S Hatoum, John M Hettema, Emma C Johnson, Katherine G Jonas, James A Knowles, Karestan C Koenen, Adam X Maihofer, Travis T Mallard, Manuel Mattheisen, Karen S Mitchell, Benjamin M Neale, Caroline M Nievergelt, John I Nurnberger, Kevin S O’Connell, Roseann E Peterson, Elise B Robinson, Sandra S Sanchez-Roige, Susan L Santangelo, Jeremiah M Scharf, Hreinn Stefansson, Kari Stefansson, Murray B Stein, Nora I Strom, Laura M Thornton, Elliot M Tucker-Drob, Brad Verhulst, Irwin D Waldman, G Bragi Walters, Naomi R Wray, Dongmei Yu, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nicotine Dependence GenOmics (iNDiGO) Consortium, Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Phil H Lee, Kenneth S Kendler, Jordan W Smoller
Journal: Nature
Published: 10 December 2025
Type: Research article
Status: code verified (how the code is found and verified)
DOI: 10.1038/s41586-025-09820-3
License: CC BY-NC-ND
Institutions: University of Colorado Boulder (United States), University of Colorado System (United States), Amsterdam Neuroscience (Netherlands), Vrije Universiteit Amsterdam (Netherlands), Amsterdam University Medical Centers (Netherlands), Oslo University Hospital (Norway), University of Oslo (Norway), University of California, Los Angeles (United States), Amgen (United States) (United States), Mayo Clinic (United States), Broad Institute (United States), Harvard University (United States), Massachusetts General Hospital (United States), Stanley Center for Psychiatric Research (United States), Aarhus University (Denmark), Lundbeck Foundation (Denmark), King's College London (United Kingdom), Helmholtz Munich (Germany), ETH Zurich (Switzerland), Technical University of Munich (Germany), Massachusetts Institute of Technology (United States), Indiana University Indianapolis (United States), Indiana University School of Medicine (United States), SUNY Upstate Medical University (United States), Radboud University Nijmegen (Netherlands), Radboud University Medical Center (Netherlands), Donders Institute for Brain, Cognition and Behaviour (Netherlands), Children's Hospital of Philadelphia (United States), University of Pennsylvania (United States), Yale University (United States), VA Connecticut Healthcare System (United States), Washington University in St. Louis (United States), Texas A&M University (United States), Stony Brook University (United States), Rutgers, The State University of New Jersey (United States), University of California San Diego (United States), VA San Diego Healthcare System (United States), Center of Excellence for Stress and Mental Health (United States), Dalhousie University (Canada), Karolinska Institutet (Sweden), Stockholm Health Care Services (Sweden), Institut für Psychiatrische Phänomik und Genomik (Germany), Ludwig-Maximilians-Universität München (Germany), Boston University (United States), VA Boston Healthcare System (United States), SUNY Downstate Health Sciences University (United States), Tufts University (United States), Vanderbilt University (United States), Brigham and Women's Hospital (United States), deCODE Genetics (Iceland) (Iceland), University of Iceland (Iceland), University of North Carolina at Chapel Hill (United States), Humboldt-Universität zu Berlin (Germany), The University of Texas at Austin (United States), Emory University (United States), The University of Queensland (Australia), University of Oxford (United Kingdom), Institute for Molecular Bioscience (Australia), University of Utah (United States), University of Mannheim (Germany), Virginia Commonwealth University (United States)
Categories: genetics / omics (modality), human (organism), depression (population), schizophrenia / psychosis (population), bipolar (population)

Data

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   :alt: OSCR

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