Intestinal interoceptive dysfunction drives age-associated cognitive decline.

1. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA USA
2. Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania,Philadelphia, PA USA
3. Monell Chemical Senses Center,Philadelphia, PA USA
4. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA USA
5. Arc Institute,Palo Alto, CA USA
6. Department of Pathology, Stanford University,Stanford, CA USA
7. Department of Biological Chemistry, University of California Irvine,Irvine, CA USA
8. School of Microbiology and APC Microbiome Ireland, University College Cork,Cork, Ireland
9. Calico Life Sciences LLC,San Francisco, CA USA
10. Division of Allergy and Immunology, Children’s Hospital of Philadelphia,Philadelphia, PA USA
11. Department of Biology, University of Pennsylvania,Philadelphia, PA USA
12. Department of Psychology and Stanford Center on Longevity, Stanford University,Stanford, CA USA
13. Metabolomics Core, Penn Cardiovascular Institute, University of Pennsylvania,Philadelphia, PA USA

@article{cox2026intestinal,
author = {Cox, Timothy O. and Devason, Ashwarya S. and de Araujo, Alan and Mason, Sydney and Subramanian, Madhav and Salvador, Andrea F. M. and Descamps, Hélène C. and Kim, Junwon and Zhu, Yixuan and Litichevskiy, Lev and Jung, Sunhee and Song, Won-Suk and Cortés-Martín, Adrián and Henderson, Nathan T. and Huang, Kuei-Pin and Nguyen, Thao and Sae-Lee, Wisath and Umana, Iboro C. and Sacta, Maria and Rahman, Ryan J. and Wisser, Stephen and Nelson, J. Andrew D. and Golynker, Ilona and McSween, Alana M. and Hohmann, Eric F. and Patel, Shaan and Bub, Anna L. and Soekler, Clara and Blank, Niklas and Hoxha, Kevt’her and Boccia, Lavinia and Wong, Andrea C. and Bahnsen, Klaas and Kim, Jihee and Biderman, Natalie and Abbasian, Dina and Shoffler, Clarissa and Petucci, Christopher and McAllister, Fiona E. and Alhadeff, Amber L. and Fuccillo, Marc V. and Hill, Colin and Jang, Cholsoon and Betley, J. Nicholas and de Lartigue, Guillaume and Lee, Virginia Y.-M. and Levy, Maayan and Thaiss, Christoph A.},
title = {{Intestinal interoceptive dysfunction drives age-associated cognitive decline}},
journal = {Nature},
year = {2026},
month = mar,
volume = {652},
number = {8109},
pages = {442--450},
publisher = {Nature Portfolio},
issn = {0028-0836},
doi = {10.1038/s41586-026-10191-6},
url = {https://doi.org/10.1038/s41586-026-10191-6},
pmid = {41813891},
pmcid = {PMC13061634}
}

TY - JOUR
AU - Cox, Timothy O.
AU - Devason, Ashwarya S.
AU - de Araujo, Alan
AU - Mason, Sydney
AU - Subramanian, Madhav
AU - Salvador, Andrea F. M.
AU - Descamps, Hélène C.
AU - Kim, Junwon
AU - Zhu, Yixuan
AU - Litichevskiy, Lev
AU - Jung, Sunhee
AU - Song, Won-Suk
AU - Cortés-Martín, Adrián
AU - Henderson, Nathan T.
AU - Huang, Kuei-Pin
AU - Nguyen, Thao
AU - Sae-Lee, Wisath
AU - Umana, Iboro C.
AU - Sacta, Maria
AU - Rahman, Ryan J.
AU - Wisser, Stephen
AU - Nelson, J. Andrew D.
AU - Golynker, Ilona
AU - McSween, Alana M.
AU - Hohmann, Eric F.
AU - Patel, Shaan
AU - Bub, Anna L.
AU - Soekler, Clara
AU - Blank, Niklas
AU - Hoxha, Kevt’her
AU - Boccia, Lavinia
AU - Wong, Andrea C.
AU - Bahnsen, Klaas
AU - Kim, Jihee
AU - Biderman, Natalie
AU - Abbasian, Dina
AU - Shoffler, Clarissa
AU - Petucci, Christopher
AU - McAllister, Fiona E.
AU - Alhadeff, Amber L.
AU - Fuccillo, Marc V.
AU - Hill, Colin
AU - Jang, Cholsoon
AU - Betley, J. Nicholas
AU - de Lartigue, Guillaume
AU - Lee, Virginia Y.-M.
AU - Levy, Maayan
AU - Thaiss, Christoph A.
TI - Intestinal interoceptive dysfunction drives age-associated cognitive decline
T2 - Nature
J2 - Nature
PY - 2026
DA - 2026/03/11
VL - 652
IS - 8109
SP - 442
EP - 450
SN - 0028-0836
PB - Nature Portfolio
DO - 10.1038/s41586-026-10191-6
UR - https://doi.org/10.1038/s41586-026-10191-6
LA - en
ER -

{
"id": "10.1038/s41586-026-10191-6",
"type": "article-journal",
"title": "Intestinal interoceptive dysfunction drives age-associated cognitive decline",
"container-title": "Nature",
"author": [
{
"family": "Cox",
"given": "Timothy O."
},
{
"family": "Devason",
"given": "Ashwarya S."
},
{
"family": "de Araujo",
"given": "Alan"
},
{
"family": "Mason",
"given": "Sydney"
},
{
"family": "Subramanian",
"given": "Madhav"
},
{
"family": "Salvador",
"given": "Andrea F. M."
},
{
"family": "Descamps",
"given": "Hélène C."
},
{
"family": "Kim",
"given": "Junwon"
},
{
"family": "Zhu",
"given": "Yixuan"
},
{
"family": "Litichevskiy",
"given": "Lev"
},
{
"family": "Jung",
"given": "Sunhee"
},
{
"family": "Song",
"given": "Won-Suk"
},
{
"family": "Cortés-Martín",
"given": "Adrián"
},
{
"family": "Henderson",
"given": "Nathan T."
},
{
"family": "Huang",
"given": "Kuei-Pin"
},
{
"family": "Nguyen",
"given": "Thao"
},
{
"family": "Sae-Lee",
"given": "Wisath"
},
{
"family": "Umana",
"given": "Iboro C."
},
{
"family": "Sacta",
"given": "Maria"
},
{
"family": "Rahman",
"given": "Ryan J."
},
{
"family": "Wisser",
"given": "Stephen"
},
{
"family": "Nelson",
"given": "J. Andrew D."
},
{
"family": "Golynker",
"given": "Ilona"
},
{
"family": "McSween",
"given": "Alana M."
},
{
"family": "Hohmann",
"given": "Eric F."
},
{
"family": "Patel",
"given": "Shaan"
},
{
"family": "Bub",
"given": "Anna L."
},
{
"family": "Soekler",
"given": "Clara"
},
{
"family": "Blank",
"given": "Niklas"
},
{
"family": "Hoxha",
"given": "Kevt’her"
},
{
"family": "Boccia",
"given": "Lavinia"
},
{
"family": "Wong",
"given": "Andrea C."
},
{
"family": "Bahnsen",
"given": "Klaas"
},
{
"family": "Kim",
"given": "Jihee"
},
{
"family": "Biderman",
"given": "Natalie"
},
{
"family": "Abbasian",
"given": "Dina"
},
{
"family": "Shoffler",
"given": "Clarissa"
},
{
"family": "Petucci",
"given": "Christopher"
},
{
"family": "McAllister",
"given": "Fiona E."
},
{
"family": "Alhadeff",
"given": "Amber L."
},
{
"family": "Fuccillo",
"given": "Marc V."
},
{
"family": "Hill",
"given": "Colin"
},
{
"family": "Jang",
"given": "Cholsoon"
},
{
"family": "Betley",
"given": "J. Nicholas"
},
{
"family": "de Lartigue",
"given": "Guillaume"
},
{
"family": "Lee",
"given": "Virginia Y.-M."
},
{
"family": "Levy",
"given": "Maayan"
},
{
"family": "Thaiss",
"given": "Christoph A."
}
],
"container-title-short": "Nature",
"volume": "652",
"issue": "8109",
"page": "442-450",
"DOI": "10.1038/s41586-026-10191-6",
"PMID": "41813891",
"PMCID": "PMC13061634",
"ISSN": "0028-0836",
"publisher": "Nature Portfolio",
"URL": "https://doi.org/10.1038/s41586-026-10191-6",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
11
]
]
}
}