OSCR

A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder.

Overview

Authors: Yunhao Wu1,2, Chuanbin Ning3, Lei Shi4, Jijun Wang5, Kuanghao Ye1,2, Ziyu Shen6, Yuhan Wang7, Duanwei Wang3, Huihui Guo3, Xian Qiu8,9, Yixin Pan1,2, Halimureti Paerhati1,2, Debo Li4, Yu Mo4, Jing Wan10, Huilin Hu4, Yu Cao3, Bomin Sun1,2,3, Xin Lv1,2,3,4,11
ORCID iDs: Xin Lv
  1. Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  3. Shandong Mental Health Center, Shandong, China
  4. The Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, China
  5. Shanghai Mental Health Center, Shanghai, China
  6. Department of Functional Neurosurgery, Shanghai International Medical Center, Shanghai, China
  7. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  8. Department of Nursing, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China
  9. Shanghai Jiao Tong University School of Nursing, Shanghai, China
  10. Zhongshan Third People’s Hospital, Zhongshan, China
  11. Hainan International Medical Center, Shanghai Jiao Tong University School of Medicine, Hainan, China
Institutions: Shanghai Jiao Tong University (China); Ruijin Hospital (China); Shandong Mental Health Center (China); Guangxi Zhuang Autonomous Region Brain Hospital (China); Shanghai Mental Health Center (China); Shanghai International Medical Center (China); Capital Medical University (China); Beijing Tian Tan Hospital (China)
Journal: NPJ digital medicine, volume 9, issue 1, article 392
Dates: received 6 August 2025; accepted 14 March 2026; published online 28 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41746-026-02575-9 · PMID 41904320 · PMCID PMC13194911 · OpenAlex W7142412159
Open access: gold, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: other (modality), human (organism), depression (population), clinical / translational (subfield)
Methods: Statistics
Keywords: Diseases, Health care, Medical research, Neurology, Neuroscience, Psychology
Topic: Transcranial Magnetic Stimulation Studies (Neurology, Neuroscience), according to OpenAlex
Funding: Shanghai Municipal Science and Technology Major Project (2021SHZDZX); 2024 Shanghai Nursing Association Research Fund (2024MS-B13); National Natural Science Foundation of China (82271515); 2024 Shanghai Ruijin Hospital Nursing Research Fund (RJHK-2024-001); Nursing Development Program of Shanghai Jiao Tong University School of Medicine (SJTUHLXK2022); Project supported by the Young Scientists Fund of the National Natural Science Fundation of China (82401813); the National Natural Science Foundation of China (T2293730)
Citations: not cited yet (Europe PMC); 48 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41746-026-02575-9.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41746-026-02575-9.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 6 keywords, 7 funders, 47 references.

Cite

This paper

Wu, Y., Ning, C., Shi, L., Wang, J., Ye, K., Shen, Z., Wang, Y., Wang, D., Guo, H., Qiu, X., Pan, Y., Paerhati, H., Li, D., Mo, Y., Wan, J., Hu, H., Cao, Y., Sun, B., & Lv, X. (2026). A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder. NPJ digital medicine, 9(1), 392. https://doi.org/10.1038/s41746-026-02575-9

BibTeX

@article{wu2026multicenter,
author = {Wu, Yunhao and Ning, Chuanbin and Shi, Lei and Wang, Jijun and Ye, Kuanghao and Shen, Ziyu and Wang, Yuhan and Wang, Duanwei and Guo, Huihui and Qiu, Xian and Pan, Yixin and Paerhati, Halimureti and Li, Debo and Mo, Yu and Wan, Jing and Hu, Huilin and Cao, Yu and Sun, Bomin and Lv, Xin},
title = {{A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder}},
journal = {NPJ digital medicine},
year = {2026},
month = mar,
volume = {9},
number = {1},
pages = {392},
publisher = {Nature Publishing Group},
issn = {2398-6352},
doi = {10.1038/s41746-026-02575-9},
url = {https://doi.org/10.1038/s41746-026-02575-9},
pmid = {41904320},
pmcid = {PMC13194911}
}

RIS

TY - JOUR
AU - Wu, Yunhao
AU - Ning, Chuanbin
AU - Shi, Lei
AU - Wang, Jijun
AU - Ye, Kuanghao
AU - Shen, Ziyu
AU - Wang, Yuhan
AU - Wang, Duanwei
AU - Guo, Huihui
AU - Qiu, Xian
AU - Pan, Yixin
AU - Paerhati, Halimureti
AU - Li, Debo
AU - Mo, Yu
AU - Wan, Jing
AU - Hu, Huilin
AU - Cao, Yu
AU - Sun, Bomin
AU - Lv, Xin
TI - A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder
T2 - NPJ digital medicine
J2 - NPJ Digit Med
PY - 2026
DA - 2026/03/28
VL - 9
IS - 1
SP - 392
SN - 2398-6352
PB - Nature Publishing Group
DO - 10.1038/s41746-026-02575-9
UR - https://doi.org/10.1038/s41746-026-02575-9
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41746-026-02575-9",
"type": "article-journal",
"title": "A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder",
"container-title": "NPJ digital medicine",
"author": [
{
"family": "Wu",
"given": "Yunhao"
},
{
"family": "Ning",
"given": "Chuanbin"
},
{
"family": "Shi",
"given": "Lei"
},
{
"family": "Wang",
"given": "Jijun"
},
{
"family": "Ye",
"given": "Kuanghao"
},
{
"family": "Shen",
"given": "Ziyu"
},
{
"family": "Wang",
"given": "Yuhan"
},
{
"family": "Wang",
"given": "Duanwei"
},
{
"family": "Guo",
"given": "Huihui"
},
{
"family": "Qiu",
"given": "Xian"
},
{
"family": "Pan",
"given": "Yixin"
},
{
"family": "Paerhati",
"given": "Halimureti"
},
{
"family": "Li",
"given": "Debo"
},
{
"family": "Mo",
"given": "Yu"
},
{
"family": "Wan",
"given": "Jing"
},
{
"family": "Hu",
"given": "Huilin"
},
{
"family": "Cao",
"given": "Yu"
},
{
"family": "Sun",
"given": "Bomin"
},
{
"family": "Lv",
"given": "Xin"
}
],
"container-title-short": "NPJ Digit Med",
"volume": "9",
"issue": "1",
"page": "392",
"DOI": "10.1038/s41746-026-02575-9",
"PMID": "41904320",
"PMCID": "PMC13194911",
"ISSN": "2398-6352",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41746-026-02575-9",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
28
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41380-026-03560-0
Optimized multichannel 4 mA vs conventional transcranial direct current stimulation for major depressive disorder: A randomized sham-controlled trial.
Journal: Molecular psychiatry
In common: depression, other, clinical / translational, 6 references
[2] doi:10.1111/ejn.70042
μ-Transcranial Alternating Current Stimulation Induces Phasic Entrainment and Plastic Facilitation of Corticospinal Excitability.
Journal: The European journal of neuroscience
In common: other, 7 references
[3] doi:10.3389/fnins.2024.1390250 [code]
Target engagement of the subgenual anterior cingulate cortex with transcranial temporal interference stimulation in major depressive disorder: a protocol for a randomized sham-controlled trial.
Journal: Frontiers in neuroscience
In common: depression, clinical / translational, 6 references
[4] doi:10.1155/2022/6197505
Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study.
Journal: Neural plasticity
In common: other, 5 references
[5] doi:10.3390/brainsci14121284 [code]
The Modulatory Effects of Transcranial Alternating Current Stimulation on Brain Oscillatory Patterns in the Beta Band in Healthy Older Adults.
Journal: Brain sciences
In common: other, 5 references
[6] doi:10.1038/s41467-025-65179-z [code]
Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.
Journal: Nature communications
In common: depression, clinical / translational, 1 reference, author Xin Lv
[7] doi:10.3389/fpsyt.2024.1358018
One size does not fit all: notable individual variation in brain activity correlates of antidepressant treatment response.
Journal: Frontiers in psychiatry
In common: depression, clinical / translational, 4 references
[8] doi:10.1371/journal.pone.0319702
Impact of transcranial alternating current stimulation on psychological stress: A functional near-infrared spectroscopy study.
Journal: PloS one
In common: other, 4 references
[9] doi:10.1038/s41598-023-29124-8
Face pareidolia is enhanced by 40 Hz transcranial alternating current stimulation (tACS) of the face perception network.
Journal: Scientific reports
In common: other, 4 references
[10] doi:10.7717/peerj.17144 [code]
Tailoring transcranial alternating current stimulation based on endogenous event-related P3 to modulate premature responses: a feasibility study.
Journal: PeerJ
In common: other, 4 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.

Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.