Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks.
The 4 matches
- [1] § Graph representation learning ↔ BrainADNet.ipynb, lines 78–142 · score 0.64 · adjacency matrix, KNN graph, correlation matrix, sparse, Fisher, transform
- [2] § BrainADNet framework › Skip-GCN ↔ BrainADNet.ipynb, lines 229–300 · score 0.62 · ChebConv, skip connections, ReLU, dropout, batch, layers
- [3] § BrainADNet framework ↔ BrainADNet.ipynb, lines 144–196 · score 0.52 · sliding window, KNN graph, Fisher, transformation, demographic, correlation
- [4] § BrainADNet framework › Skip-GCN ↔ BrainADNet.ipynb, lines 229–300 · score 0.52 · Skip connections, Cheb, softmax, linear, classes, global
Paper
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The authors' code
Jupyter notebook · 509 lines · 16 KB · no license · 4 matches
- # %%
- import os
- import scipy.io
- import numpy as np
- import random
- import pandas as pd
- import torch
- from sklearn.model_selection import train_test_split
- from torch_geometric.data import InMemoryDataset, Data
- from torch_geometric.utils import dense_to_sparse
- import torch.nn.functional as func
- import torch.optim as optim
- from torch_geometric.loader import DataLoader
- from torch_geometric.nn import GCNConv, global_mean_pool
- from torch_geometric.nn import GATConv, ChebConv
- import torch.nn as nn
- from collections import Counter
- import os.path as osp
- import csv
- from sklearn.metrics import roc_auc_score
- from sklearn.metrics import accuracy_score, f1_score, recall_score, confusion_matrix
- from sklearn.model_selection import StratifiedKFold, StratifiedShuffleSplit
- # %%
- seed=89
- atlas_name= "AAL"
- dataset_name = "MDDvHC"
- if atlas_name == "AAL":
- start = 0
- end = 116
- elif atlas_name == "Craddock":
- start = 228
- end = 428
- elif atlas_name == "Dosenbach":
- start = 1408
- end = 1568
- else:
- exit()
- # %%
- # Function to set seed
- def set_seed(seed):
- random.seed(seed)
- np.random.seed(seed)
- torch.manual_seed(seed)
- if torch.cuda.is_available():
- torch.cuda.manual_seed(seed)
- torch.cuda.manual_seed_all(seed)
- torch.backends.cudnn.deterministic = True
- torch.backends.cudnn.benchmark = False
- torch.use_deterministic_algorithms(True)
- # Environment variables for reproducibility
- os.environ['PYTHONHASHSEED'] = str(seed)
- os.environ['CUBLAS_WORKSPACE_CONFIG'] = ':4096:8'
- os.environ['CUDA_LAUNCH_BLOCKING'] = '1'
- set_seed(seed)
- def seed_worker(worker_id):
- worker_seed = torch.initial_seed() % 2**32
- numpy.random.seed(worker_seed)
- random.seed(worker_seed)
- g = torch.Generator()
- g.manual_seed(0)
- # %%
- from sklearn.preprocessing import StandardScaler
- def normalize(matrix):
- scaler = StandardScaler()
- normalized_matrix = scaler.fit_transform(matrix)
- return normalized_matrix
- # %%
- import numpy as np
- from scipy.sparse import coo_matrix
- import torch
- from torch_geometric.utils import dense_to_sparse
- from torch_geometric.data import InMemoryDataset, Data
- def fisher_z_transform(correlation_matrix, epsilon=1e-5):
- return 0.5 * np.log((1 + correlation_matrix) / (1 - correlation_matrix + epsilon))
- def to_tensor(X_featgraph, X_adjgraph, Y):
- datalist = []
- for i in range(len(Y)):
- ty = Y[i]
- y = torch.tensor([ty]).long()
- adjacency = X_adjgraph[i]
- feature = X_featgraph[i]
- x = torch.from_numpy(feature).float()
- adj= adjacency
- adj = torch.from_numpy(adj).float()
- edge_index, edge_attr = dense_to_sparse(adj)
- datalist.append(Data(x=x, edge_index=edge_index, edge_attr=edge_attr, y=y))
- return datalist
- def compute_KNN_graph(matrix, k_degree=10):
- """ Calculate the adjacency matrix from the connectivity matrix."""
- matrix = np.abs(matrix)
- idx = np.argsort(-matrix)[:, 0:k_degree]
- matrix.sort()
- matrix = matrix[:, ::-1]
- matrix = matrix[:, 0:k_degree]
- A = adjacency(matrix, idx).astype(np.float32)
- return A
- def adjacency(dist, idx):
- m, k = dist.shape
- assert m, k == idx.shape
- assert dist.min() >= 0
- # Weight matrix.
- I = np.arange(0, m).repeat(k)
- J = idx.reshape(m * k)
- V = dist.reshape(m * k)
- W = coo_matrix((V, (I, J)), shape=(m, m))
- # No self-connections.
- W.setdiag(0)
- # Non-directed graph.
- bigger = W.T > W
- W = W - W.multiply(bigger) + W.T.multiply(bigger)
- return W.todense()
- # %%
- def create_graph_sliding_window_demographics(X, D, Y, start, end, region=True):
- S = 30 # Sliding Step
- T = 60 # Window Size
- X_adjgraph=[]
- X_featgraph = []
- Y_list = []
- num_samples_per_subject = []
- for i in range(len(Y)):
- #select rows according to atlas
- bold_matrix = X[i]
- n = bold_matrix.shape[0]
- demog = D[i]
- demog_expanded = np.expand_dims(demog, axis=0)
- demog_expanded = np.repeat(demog_expanded, n, axis=0)
- temp_y = Y[i]
- num_rows, num_cols = bold_matrix.shape
- num_samples = 0
- for start_idx in range(0, num_cols - T + 1, S):
- end_idx = start_idx + T
- if end_idx <= num_cols:
- if region == True:
- window_data = bold_matrix[:, start_idx:end_idx] #RxR
- else:
- window_data = np.transpose(bold_matrix[:, start_idx:end_idx]) #TxT
- window_data1 = np.corrcoef(window_data)
- correlation_matrix_fisher = fisher_z_transform(window_data1)
- correlation_matrix_fisher = np.around(correlation_matrix_fisher, 8)
- result_matrix = np.concatenate((correlation_matrix_fisher, demog_expanded), axis=1)
- knn_graph = compute_KNN_graph(correlation_matrix_fisher)
- if region == True:
- X_featgraph.append(result_matrix)
- else:
- X_featgraph.append(window_data)
- X_adjgraph.append(knn_graph)
- Y_list.append(temp_y)
- num_samples = num_samples+1
- num_samples_per_subject.append(num_samples)
- return X_featgraph, X_adjgraph, Y_list, num_samples_per_subject
- # %%
- def create_graph_demographics(X, D, Y, start, end, region=True):
- X_adjgraph=[]
- X_featgraph = []
- for i in range(len(Y)):
- if region == True:
- bold_matrix = X[i] #RxR
- else:
- bold_matrix = np.transpose(X[i]) #TxT
- n= bold_matrix.shape[0]
- demog_expanded = np.expand_dims(D[i], axis=0)
- demog_expanded = np.repeat(demog_expanded, n, axis=0)
- window_data1 = np.corrcoef(bold_matrix)
- correlation_matrix_fisher = fisher_z_transform(window_data1)
- correlation_matrix_fisher = np.around(correlation_matrix_fisher, 8)
- knn_graph = compute_KNN_graph(correlation_matrix_fisher)
- result_matrix = np.concatenate((correlation_matrix_fisher, demog_expanded), axis=1)
- if region == True:
- X_featgraph.append(result_matrix)
- else:
- X_featgraph.append(bold_matrix)
- X_adjgraph.append(knn_graph)
- return X_featgraph, X_adjgraph, Y
- # %%
- import torch
- import torch.nn as nn
- import torch.nn.functional as F
- from torch_geometric.nn import ChebConv, global_mean_pool,GATConv
- class SkipConnModel(nn.Module):
- def __init__(self, num_features_R, num_classes, k_order, dropout_prob=0.5):
- super(SkipConnModel, self).__init__()
- self.dropout_prob = dropout_prob
- self.num_layers = 6
- self.convs = nn.ModuleList()
- self.bns = nn.ModuleList()
- self.convs.append(ChebConv(num_features_R, 128, K=3, normalization='sym'))
- self.bns.append(nn.BatchNorm1d(128))
- self.convs.append(ChebConv(128, 128, K=3, normalization='sym'))
- self.bns.append(nn.BatchNorm1d(128))
- self.convs.append(ChebConv(128, 128, K=3, normalization='sym'))
- self.bns.append(nn.BatchNorm1d(128))
- self.out_fc = nn.Linear(128, num_classes)
- self.weights = torch.nn.Parameter(torch.randn(len(self.convs)))
- def reset_parameters(self):
- for conv in self.convs:
- conv.reset_parameters()
- for bn in self.bns:
- bn.reset_parameters()
- self.out_fc.reset_parameters()
- torch.nn.init.normal_(self.weights)
- def forward(self, data_R):
- x1, edge_index1, edge_attr1 = data_R.x, data_R.edge_index, data_R.edge_attr
- batch1 = data_R.batch
- layer_out1 = []
- x1 = self.convs[0](x1, edge_index1, edge_attr1)
- x1 = self.bns[0](x1)
- x1 = F.relu(x1, inplace=True)
- layer_out1.append(x1)
- x1 = F.dropout(x1, p=self.dropout_prob, training=self.training)
- x1 = self.convs[1](x1, edge_index1, edge_attr1)
- x1 = self.bns[1](x1)
- x1 = F.relu(x1, inplace=True)
- x1 = x1 + 0.8 * layer_out1[0]
- layer_out1.append(x1)
- x1 = F.dropout(x1, p=self.dropout_prob, training=self.training)
- x1 = self.convs[2](x1, edge_index1, edge_attr1)
- x1 = self.bns[2](x1)
- x1 = F.relu(x1, inplace=True)
- x1 = x1 + 0.8 * layer_out1[1]
- layer_out1.append(x1)
- weight = F.softmax(self.weights, dim=0)
- weighted_outs = [layer_out1[i] * weight[i] for i in range(len(layer_out1))]
- emb = sum(weighted_outs)
- pooled_emb = global_mean_pool(emb, batch1)
- x = self.out_fc(pooled_emb)
- return x, pooled_emb
- # %%
- def DECOV(embeddings):
- embeddings_t = embeddings.T
- C = torch.cov(embeddings_t)
- C_fro_norm = torch.norm(C, p='fro')
- diag_elements = torch.diag(C,0)
- C2_l2norm_diag = torch.norm(diag_elements)
- L_DECOV = (C_fro_norm ** 2) - (C2_l2norm_diag ** 2)
- return L_DECOV
- # %%
- def GCN_train(loader):
- model.train()
- pred = []
- label = []
- loss_all = 0
- alpha= 1
- beta = 1e-8
- for data in loader:
- data = data.to(device)
- optimizer.zero_grad()
- output, pooled = model(data)
- pooled = pooled.to('cpu')
- loss_decov = DECOV(pooled)
- loss_decov = loss_decov.to(device)
- pooled = pooled.to(device)
- loss_ce = func.cross_entropy(output, data.y)
- loss = alpha * loss_ce + beta *loss_decov
- loss.backward()
- loss_all += data.num_graphs * loss.item()
- optimizer.step()
- pred.append(func.softmax(output, dim=1).max(dim=1)[1])
- label.append(data.y)
- y_pred = torch.cat(pred, dim=0).cpu().detach().numpy()
- y_true = torch.cat(label, dim=0).cpu().detach().numpy()
- tn, fp, fn, tp = confusion_matrix(y_true, y_pred).ravel()
- epoch_sen = tp / (tp + fn)
- epoch_spe = tn / (tn + fp)
- epoch_acc = (tn + tp) / (tn + tp + fn + fp)
- f1 = f1_score(y_true, y_pred)
- return epoch_sen, epoch_spe, epoch_acc, f1, loss_all/len(loader)
- def GCN_test(loader):
- model.eval()
- pred = []
- scores = []
- label = []
- loss_all = 0
- for data in loader:
- data = data.to(device)
- output , pooled= model(data)
- loss_ce = func.cross_entropy(output, data.y)
- loss = loss_ce
- loss_all += data.num_graphs * loss.item()
- softmax_output = func.softmax(output, dim=1)
- scores.append(softmax_output[:, 1])
- pred.append(softmax_output.max(dim=1)[1])
- label.append(data.y)
- y_pred = torch.cat(pred, dim=0).cpu().detach().numpy()
- y_scores = torch.cat(scores, dim=0).cpu().detach().numpy()
- y_true = torch.cat(label, dim=0).cpu().detach().numpy()
- tn, fp, fn, tp = confusion_matrix(y_true, y_pred).ravel()
- epoch_sen = tp / (tp + fn)
- epoch_spe = tn / (tn + fp)
- epoch_acc = (tn + tp) / (tn + tp + fn + fp)
- epoch_f1 = f1_score(y_true, y_pred)
- epoch_auc = roc_auc_score(y_true, y_scores)
- return epoch_sen, epoch_spe, epoch_acc, epoch_f1, epoch_auc,loss_all / len(loader)
- # %%
- X_new = np.load(f'./{dataset_name}/{atlas_name}/X.npz')
- X_loaded = [X_new[key] for key in X_new.files]
- X_loaded = [normalize(matrix) for matrix in X_loaded]
- print(X_loaded[0].shape)
- Y_loaded = np.load(f'./{dataset_name}/{atlas_name}/Y.npy')
- print(Y_loaded)
- demographic_data = pd.read_csv(f'./{dataset_name}/{atlas_name}/demographics_data.csv')
- demographics = demographic_data[['Age', 'Edu', 'Sex']].values
- # %%
- skf = StratifiedKFold(n_splits=10, shuffle=True, random_state=seed)
- device = torch.device('cpu')
- eval_metrics2 = np.zeros((skf.n_splits, 5))
- eval_metrics3 = np.zeros((skf.n_splits, 5))
- dataset = X_loaded
- labels = Y_loaded
- # %%
- for n_fold, (train_val, test) in enumerate(skf.split(dataset, labels)):
- model = SkipConnModel((end - start + 3), 2,3).to(device)
- optimizer = torch.optim.Adam(model.parameters(), lr=0.001, weight_decay=5e-4)
- train_val_dataset = [dataset[i] for i in train_val]
- test_dataset = [dataset[i] for i in test]
- train_val_labels = labels[train_val]
- test_labels = labels[test]
- train_val_demographics = demographics[train_val]
- test_demographics = demographics[test]
- train_val_index = np.arange(len(train_val_dataset))
- train_idx, val_idx, _, _ = train_test_split(
- train_val_index,
- train_val_labels,
- test_size=0.1,
- shuffle=True,
- stratify=train_val_labels,
- random_state=seed
- )
- train_dataset = [train_val_dataset[i] for i in train_idx]
- val_dataset = [train_val_dataset[i] for i in val_idx]
- train_labels = [train_val_labels[i] for i in train_idx]
- val_labels = [train_val_labels[i] for i in val_idx]
- train_demographics = [train_val_demographics[i] for i in train_idx]
- val_demographics = [train_val_demographics[i] for i in val_idx]
- X_train_featgraph, X_train_adjgraph, Y_train, _ = create_graph_sliding_window_demographics(train_dataset, train_demographics, train_labels, start, end, region=True)
- X_val_featgraph, X_val_adjgraph, Y_val = create_graph_demographics(val_dataset, val_demographics, val_labels, start, end, region=True)
- X_test_featgraph, X_test_adjgraph, Y_test = create_graph_demographics(test_dataset, test_demographics, test_labels, start, end, region=True)
- X_train_datalist = to_tensor(X_train_featgraph, X_train_adjgraph, Y_train)
- X_val_datalist = to_tensor(X_val_featgraph, X_val_adjgraph, Y_val)
- X_test_datalist = to_tensor(X_test_featgraph, X_test_adjgraph, Y_test)
- train_loader = DataLoader(X_train_datalist, batch_size=32, shuffle=True, num_workers=0, worker_init_fn=seed_worker, generator=g)
- val_loader = DataLoader(X_val_datalist, batch_size=32, shuffle=True, num_workers=0, worker_init_fn=seed_worker, generator=g)
- test_loader = DataLoader(X_test_datalist, batch_size=32, shuffle=True, num_workers=0, worker_init_fn=seed_worker, generator=g)
- best_test_acc2 = 0
- best_test_f12 = 0
- best_test_sen2 = 0
- best_test_spe2 = 0
- best_test_auc2 = 0
- best_val_acc3 = 0
- best_test_acc3 = 0
- best_test_f13 = 0
- best_test_sen3 = 0
- best_test_spe3 = 0
- best_test_auc3 = 0
- for epoch in range(50):
- _, _, _, _, t_loss = GCN_train(train_loader)
- val_sen, val_spe, val_acc,val_f1, val_auc, v_loss = GCN_test(val_loader)
- test_sen, test_spe, test_acc,test_f1, test_auc, _ = GCN_test(test_loader)
- if test_acc > best_test_acc2:
- best_test_acc2 = test_acc
- best_test_f12 = test_f1
- best_test_sen2, best_test_spe2,best_test_auc2 = test_sen, test_spe, test_auc
- if val_acc > best_val_acc3:
- best_val_acc3 = val_acc
- best_test_f13 = test_f1
- best_test_sen3, best_test_spe3, best_test_acc3, best_test_auc3 = test_sen, test_spe, test_acc, test_auc
- print('CV: {:03d}, Epoch: {:03d}, Val Loss: {:.5f}, Val ACC: {:.5f},Val AUC: {:.5f}, Test ACC: {:.5f}, Test F1: {:.5f}, TEST SPE: {:.5f}, '
- 'TEST SEN: {:.5f}, TEST AUC: {:.5f}'.format(n_fold +1, epoch + 1, v_loss, val_acc, val_auc, test_acc,test_f1,
- test_spe,test_sen, test_auc))
- eval_metrics2[n_fold, 0] = best_test_sen2
- eval_metrics2[n_fold, 1] = best_test_spe2
- eval_metrics2[n_fold, 2] = best_test_acc2
- eval_metrics2[n_fold, 3] = best_test_f12
- eval_metrics2[n_fold, 4] = best_test_auc2
- eval_metrics3[n_fold, 0] = best_test_sen3
- eval_metrics3[n_fold, 1] = best_test_spe3
- eval_metrics3[n_fold, 2] = best_test_acc3
- eval_metrics3[n_fold, 3] = best_test_f13
- eval_metrics3[n_fold, 4] = best_test_auc3
- # %%
- print("\nResults Corresponding to Maximum val_acc")
- eval_df3 = pd.DataFrame(eval_metrics3)
- eval_df3.columns = ['SEN', 'SPE', 'ACC','F1', 'AUC-ROC']
- eval_df3.index = ['Fold_%02i' % (i + 1) for i in range(skf.n_splits)]
- print(eval_df3)
- print('Average Sensitivity: %.4f±%.4f' % (eval_metrics3[:, 0].mean(), eval_metrics3[:, 0].std()))
- print('Average Specificity: %.4f±%.4f' % (eval_metrics3[:, 1].mean(), eval_metrics3[:, 1].std()))
- print('Average Accuracy: %.4f±%.4f' % (eval_metrics3[:, 2].mean(), eval_metrics3[:, 2].std()))
- print('Average F1: %.4f±%.4f' % (eval_metrics3[:, 3].mean(), eval_metrics3[:, 3].std()))
- print('Average AUC-ROC: %.4f±%.4f' % (eval_metrics3[:, 4].mean(), eval_metrics3[:, 4].std()))
BrainADNet.ipynb at commit 3d99691, no license · at the source
Overview
- Department of Electrical Engineering, Indian Institute of Technology,Delhi, New Delhi India
- Yardi School of Artificial Intelligence, Indian Institute of Technology,Delhi, New Delhi, India India
- Bharti School of Telecommunication Technology and Management, Indian Institute of Technology,Delhi, New Delhi, India India
- Educational Technology Services Centre, Indian Institute of Technology,Delhi, New Delhi, India India
Abstract
The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.
Repository
Its files are read in the Code ↔ Paper reader above, with 4 matches between paragraphs and lines of code.
yusufm423/decorr-gnn-mdd
3d9969171ee8e9268dd266f53b216dd3eb8bf530, 18 November 2025Availability: 1 check, the latest on 30 September 2026: the link answers
- 30 September 2026: the link answers
2 files
- BrainADNet.ipynb, Jupyter, 509 lines, 4 matches
- README.md, Text, 8 lines
Code availability statement
The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:
- it points to the authors' code: yusufm423/
decorr-gnn-mdd
Read it in the paper: doi.org/10.1038/s43856-026-01395-y.
Tracing map
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What the map holds:
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- neither the text of the paper nor the code itself.
Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.
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Read it in the paper: doi.org/10.1038/s43856-026-01395-y.
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 2 keywords, 2 funders, 62 references.
Cite
This paper
Barman, J., Yusuf, M., Kumar, S., & Gandhi, T. K. (2026). Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks. Communications medicine, 6(1), 211. https://
BibTeX
@article{barman2026enhan
author = {Barman, Jyotismita and Yusuf, Mohammad and Kumar, Sandeep and Gandhi, Tapan Kumar},
title = {{Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks}},
journal = {Communications medicine},
year = {2026},
month = mar,
volume = {6},
number = {1},
pages = {211},
publisher = {Nature Publishing Group},
issn = {2730-664X},
doi = {10.1038/
url = {https://
pmid = {41772142},
pmcid = {PMC13069039}
}
RIS
TY - JOUR
AU - Barman, Jyotismita
AU - Yusuf, Mohammad
AU - Kumar, Sandeep
AU - Gandhi, Tapan Kumar
TI - Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks
T2 - Communications medicine
J2 - Commun Med (Lond)
PY - 2026
DA - 2026/
VL - 6
IS - 1
SP - 211
SN - 2730-664X
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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"type": "article-journal",
"title": "Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks",
"container-title": "Communications medicine",
"author": [
{
"family": "Barman",
"given": "Jyotismita"
},
{
"family": "Yusuf",
"given": "Mohammad"
},
{
"family": "Kumar",
"given": "Sandeep"
},
{
"family": "Gandhi",
"given": "Tapan Kumar"
}
],
"container-title-short":
"volume": "6",
"issue": "1",
"page": "211",
"DOI": "10.1038/
"PMID": "41772142",
"PMCID": "PMC13069039",
"ISSN": "2730-664X",
"publisher": "Nature Publishing Group",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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2026,
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]
]
}
}
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