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Plasma acetic acid mediates the relationship between gut microbiome and various health measures in older adults.

Overview

Authors: Tiing Yee Siow1,2,3, Alex Mun-Ching Wong1,2, Ji-Tseng Fang2,4, Cheng-Hsun Chiu5,6, Yuan-Ming Yeh7,8, Mei-Ling Cheng9,10, Chi-Jen Lo10,11, Shin-Nan Lin1, Ching-Po Lin3,12,13, Cheng Hong Toh1,2
13 affiliations
  1. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou,Taoyuan, Taiwan
  2. College of Medicine, Chang Gung University,Taoyuan, Taiwan
  3. Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University,Taipei, Taiwan
  4. Department of Nephrology, Chang Gung Memorial Hospital at Linkou,Taoyuan, Taiwan
  5. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine,Taoyuan, Taiwan
  6. Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine,Taoyuan, Taiwan
  7. Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou,Taoyuan, Taiwan
  8. Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital at Linkou,Taoyuan, Taiwan
  9. Department of Biomedical Sciences, Chang Gung University,Taoyuan, Taiwan
  10. Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University,Taoyuan, Taiwan
  11. Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou,Taoyuan, Taiwan
  12. Institute of Neuroscience, National Yang Ming Chiao Tung University,Taipei, Taiwan
  13. Department of Education and Research, Taipei City Hospital,Taipei, Taiwan
Journal: Communications medicine, volume 6, issue 1, article 329
Dates: received 18 June 2025; accepted 17 March 2026; published online 9 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s43856-026-01566-x · PMID 41957526 · PMCID PMC13247043 · OpenAlex W7152560297
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing, Connectivity
Keywords: Microbiome, Endocrine system and metabolic diseases
Topic: Gut microbiota and health (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Chang Gung Memorial Hospital (CGMH) (CORPG3J0371, XMRPG3L102)
Citations: not cited yet (Europe PMC); 85 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s43856-026-01566-x.

Tracing map

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Data

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Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s43856-026-01566-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 2 keywords, 1 funder, 81 references.

Cite

This paper

Siow, T. Y., Wong, A. M.-C., Fang, J.-T., Chiu, C.-H., Yeh, Y.-M., Cheng, M.-L., Lo, C.-J., Lin, S.-N., Lin, C.-P., & Toh, C. H. (2026). Plasma acetic acid mediates the relationship between gut microbiome and various health measures in older adults. Communications medicine, 6(1), 329. https://doi.org/10.1038/s43856-026-01566-x

BibTeX

@article{siow2026plasma,
author = {Siow, Tiing Yee and Wong, Alex Mun-Ching and Fang, Ji-Tseng and Chiu, Cheng-Hsun and Yeh, Yuan-Ming and Cheng, Mei-Ling and Lo, Chi-Jen and Lin, Shin-Nan and Lin, Ching-Po and Toh, Cheng Hong},
title = {{Plasma acetic acid mediates the relationship between gut microbiome and various health measures in older adults}},
journal = {Communications medicine},
year = {2026},
month = apr,
volume = {6},
number = {1},
pages = {329},
publisher = {Nature Publishing Group},
issn = {2730-664X},
doi = {10.1038/s43856-026-01566-x},
url = {https://doi.org/10.1038/s43856-026-01566-x},
pmid = {41957526},
pmcid = {PMC13247043}
}

RIS

TY - JOUR
AU - Siow, Tiing Yee
AU - Wong, Alex Mun-Ching
AU - Fang, Ji-Tseng
AU - Chiu, Cheng-Hsun
AU - Yeh, Yuan-Ming
AU - Cheng, Mei-Ling
AU - Lo, Chi-Jen
AU - Lin, Shin-Nan
AU - Lin, Ching-Po
AU - Toh, Cheng Hong
TI - Plasma acetic acid mediates the relationship between gut microbiome and various health measures in older adults
T2 - Communications medicine
J2 - Commun Med (Lond)
PY - 2026
DA - 2026/04/09
VL - 6
IS - 1
SP - 329
SN - 2730-664X
PB - Nature Publishing Group
DO - 10.1038/s43856-026-01566-x
UR - https://doi.org/10.1038/s43856-026-01566-x
LA - en
ER -

CSL-JSON

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