OSCR

ECgo: All-optical induction of single endothelial cell injury and capillary occlusion in the brain.

Overview

Authors: Jacqueline Condrau1,2, Srinivasa R Allu3,4, Tatiana V Esipova3,4, Eva Erlebach1,2, Matthias T Wyss1,2, Chaim Glück1,2, Luca Ravotto1,2, Thomas Troxler3,4, Mikhail Drobizhev5, Marco Villa6, Paola Ceroni6, Mohamad El Amki2,7, Sergei A Vinogradov3,4, Bruno Weber1,2
ORCID iDs: Matthias T Wyss, Chaim Glück, Luca Ravotto, Thomas Troxler, Mikhail Drobizhev, Mohamad El Amki, Bruno Weber
  1. Institute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland
  2. Neuroscience Center Zurich, University and ETH Zurich, Zurich 8057, Switzerland
  3. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
  4. Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104
  5. Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717
  6. G. Ciamician Department of Chemistry, University of Bologna, Bologna 40126, Italy
  7. Department of Neurology, University Hospital Zurich, Zurich 8091, Switzerland
Institutions: University of Zurich (Switzerland); ETH Zurich (Switzerland); University of Pennsylvania (United States); Montana State University (United States); University of Bologna (Italy); University Hospital Zurich (Switzerland)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 21, article e2513515123
Dates: received 27 May 2025; accepted 6 April 2026; published online 18 May 2026; in print 26 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2513515123 · PMID 42150062 · PMCID PMC13213976 · OpenAlex W4410888607
Open access: hybrid, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.05.27.656398
Status: data only
Categories: mouse (organism)
Methods: Machine learning
Keywords: cerebral blood flow, brain capillaries, microstroke, porphyrins, photodynamic therapy
MeSH: Brain*, Capillaries*, Endothelial Cells*, Photosensitizing Agents*, Animals, Mice, Porphyrins (* major topic)
Topic: Photoreceptor and optogenetics research (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Swiss National Science Foundation (219656, 310030_219656, 182703, 310030, 310030_182703); HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) (EB033877, EB028941); NIBIB NIH HHS (R01 EB033877); HHS | NIH | National Institute of Neurological Disorders and Stroke (NS109107)
Citations: cited by 2 papers (Europe PMC); 66 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

Datasets cited

  • osf:qzdv3, at OSF; found in “Data, Materials, and Software Availability”

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2513515123.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 5 keywords, 7 MeSH terms, 4 funders, 61 references.

Cite

This paper

Condrau, J., Allu, S. R., Esipova, T. V., Erlebach, E., Wyss, M. T., Glück, C., Ravotto, L., Troxler, T., Drobizhev, M., Villa, M., Ceroni, P., Amki, M. E., Vinogradov, S. A., & Weber, B. (2026). ECgo: All-optical induction of single endothelial cell injury and capillary occlusion in the brain. Proceedings of the National Academy of Sciences of the United States of America, 123(21), e2513515123. https://doi.org/10.1073/pnas.2513515123

BibTeX

@article{condrau2026ecgo,
author = {Condrau, Jacqueline and Allu, Srinivasa R and Esipova, Tatiana V and Erlebach, Eva and Wyss, Matthias T and Glück, Chaim and Ravotto, Luca and Troxler, Thomas and Drobizhev, Mikhail and Villa, Marco and Ceroni, Paola and Amki, Mohamad El and Vinogradov, Sergei A and Weber, Bruno},
title = {{ECgo: All-optical induction of single endothelial cell injury and capillary occlusion in the brain}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = may,
volume = {123},
number = {21},
pages = {e2513515123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2513515123},
url = {https://doi.org/10.1073/pnas.2513515123},
pmid = {42150062},
pmcid = {PMC13213976}
}

RIS

TY - JOUR
AU - Condrau, Jacqueline
AU - Allu, Srinivasa R
AU - Esipova, Tatiana V
AU - Erlebach, Eva
AU - Wyss, Matthias T
AU - Glück, Chaim
AU - Ravotto, Luca
AU - Troxler, Thomas
AU - Drobizhev, Mikhail
AU - Villa, Marco
AU - Ceroni, Paola
AU - Amki, Mohamad El
AU - Vinogradov, Sergei A
AU - Weber, Bruno
TI - ECgo: All-optical induction of single endothelial cell injury and capillary occlusion in the brain
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/05/18
VL - 123
IS - 21
SP - e2513515123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2513515123
UR - https://doi.org/10.1073/pnas.2513515123
LA - en
ER -

CSL-JSON

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"DOI": "10.1073/pnas.2513515123",
"PMID": "42150062",
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"language": "en",
"issued": {
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