Inorganic phosphate and the rapid mobilization of metabolic energy in neurons.

Overview

Authors: Paul C Rosen^1,2, Shivang Sullere^1,3, Panhui Fu¹, Juan R Martínez-François¹, Daniel J Brooks¹, Erica Kim¹, Chenghua Gu^1,3, Gary Yellen¹

ORCID iDs: Paul C Rosen, Daniel J Brooks, Erica Kim, Gary Yellen

Institutions: Harvard University (United States); Massachusetts Institute of Technology (United States); Howard Hughes Medical Institute (United States)

Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 13, article e2602529123

Dates: received 22 January 2026; accepted 12 February 2026; published online 24 March 2026; in print 31 March 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1073/pnas.2602529123 · PMID 41875165 · PMCID PMC13014856 · OpenAlex W7140170057

Open access: hybrid, a free copy (OpenAlex)

Status: code verified (how the code is found and verified)

Categories: mouse (organism)

Methods: Spectral & time-frequency, Statistics

Keywords: glycolytic regulation, neuronal energy metabolism, fluorescent biosensors of metabolism, fluorescence lifetime imaging

MeSH: Energy Metabolism*, Neurons*, Phosphates*, Animals, Biosensing Techniques, Glycolysis, Mice (* major topic)

Topic: Advanced Fluorescence Microscopy Techniques (Biophysics, Biochemistry, Genetics and Molecular Biology), according to OpenAlex

Funding: Brain and Behavior Research Foundation (Young Investigator Grant); Department of Neurobiology, Harvard Medical School (Alice and Joseph Brooks Fund Postdoctoral Fellowship, Stuart H. Q. and Victoria Quan Fellowship, Edward R. and Anne G. Lefler Center Postdoctoral Fellowship); NINDS NIH HHS (R37 NS102586); HHS|NIH|National Cancer Institute (F31 CA254162); Jane Coffin Childs Memorial Fund for Medical Research (JCC) (HHMI Fellowship); NIGMS NIH HHS (R01 GM124038); HHMI (Investigator); NCI NIH HHS (F31 CA254162); HHS | NIH | National Institute of Neurological Disorders and Stroke (R37 NS102586); HHS | NIH | National Institute of General Medical Sciences (R01 GM124038)

Citations: cited by 5 papers (Europe PMC); 107 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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supp:PMC13014856/pnas.2602529123.sd04.gz

License: none: the authors keep all their rights

State: the link answers, verified on 30 September 2026

Evidence: files inventoried

Size: 1 file

Software Heritage: not checked

Found in: the supplementary material

Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation

Availability: 1 check, the latest on 30 September 2026: the link answers (HTTP 200)

30 September 2026: the link answers (HTTP 200)

At the source: pmc-oa-opendata.s3.amazonaws.com/PMC13014856.1/pnas.2602529123.sd04.gz

The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1073/pnas.2602529123.

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 7 MeSH terms, 10 funders, 105 references.

Cite

This paper

Rosen, P. C., Sullere, S., Fu, P., Martínez-François, J. R., Brooks, D. J., Kim, E., Gu, C., & Yellen, G. (2026). Inorganic phosphate and the rapid mobilization of metabolic energy in neurons. Proceedings of the National Academy of Sciences of the United States of America, 123(13), e2602529123. https://doi.org/10.1073/pnas.2602529123

BibTeX

@article{rosen2026inorganic, author = {Rosen, Paul C and Sullere, Shivang and Fu, Panhui and Martínez-François, Juan R and Brooks, Daniel J and Kim, Erica and Gu, Chenghua and Yellen, Gary}, title = {{Inorganic phosphate and the rapid mobilization of metabolic energy in neurons}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2026}, month = mar, volume = {123}, number = {13}, pages = {e2602529123}, publisher = {National Academy of Sciences}, issn = {0027-8424}, doi = {10.1073/pnas.2602529123}, url = {https://doi.org/10.1073/pnas.2602529123}, pmid = {41875165}, pmcid = {PMC13014856} }

RIS

TY - JOUR AU - Rosen, Paul C AU - Sullere, Shivang AU - Fu, Panhui AU - Martínez-François, Juan R AU - Brooks, Daniel J AU - Kim, Erica AU - Gu, Chenghua AU - Yellen, Gary TI - Inorganic phosphate and the rapid mobilization of metabolic energy in neurons T2 - Proceedings of the National Academy of Sciences of the United States of America J2 - Proc Natl Acad Sci U S A PY - 2026 DA - 2026/03/24 VL - 123 IS - 13 SP - e2602529123 SN - 0027-8424 PB - National Academy of Sciences DO - 10.1073/pnas.2602529123 UR - https://doi.org/10.1073/pnas.2602529123 LA - en ER -

CSL-JSON

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