Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates.
Overview
- Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
- Department of Psychosomatic Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
- Department of Dermatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
Abstract
Background: Cough hypersensitivity syndrome (CHS) is a characteristic of patients with chronic cough (CC). Sensitive skin syndrome (SSS), which is characterised by cutaneous pain and pruritus, may share neural hypersensitivity mechanisms with CHS. This study aimed to determine the co-morbidities, clinical profiles, and psychosomatic correlates in CC patients.
Methods: Two hundred CC patients were enrolled in this prospective cohort study. SSS was diagnosed according to established guidelines, which required the presence of subjective symptoms induced by minimal stimuli with at least one of the following positive criteria: Sensitive Scale-10 score > 13; Sensitive Scale-14 score > 18; lactic acid sting test score ≥ 3; or capsaicin test score ≥ 3. Assessments included cough severity, Visual Analogue Scale (VAS), capsaicin cough sensitivity, cough symptom score, Leicester cough questionnaire (LCQ), and psychological evaluations.
Results: Among CC patients, 44.5% (89/
Conclusion: SSS was identified in a clinically relevant subset of CC patients (especially those with RU-CC) and correlated with neural hypersensitivity and psychological distress. Early recognition of SSS in patients with CC and the early introduction of neuromodulators may offer greater therapeutic benefits and improve patient outcomes.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- zenodo:18654183, at Zenodo; found in the text, “Open scholarship”
Data availability statement
Some or all datasets generated during and/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 keywords, 18 MeSH terms, 4 funders, 54 references.
Cite
This paper
Zhang, T., Wu, H., Bai, H., Wu, J., Zhang, L., Li, R., Zhu, Y., Sha, B., Yuan, J., Zhou, Y., Xu, X., & Yu, L. (2026). Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates. Annals of medicine, 58(1), 2638047. https://
BibTeX
@article{zhang2026skin,
author = {Zhang, Tongyangzi and Wu, Heng and Bai, Haodong and Wu, Jiguang and Zhang, Lili and Li, Rongrong and Zhu, Yiqing and Sha, Bingxian and Yuan, Jiaying and Zhou, Yaxing and Xu, Xianghuai and Yu, Li},
title = {{Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates}},
journal = {Annals of medicine},
year = {2026},
month = mar,
volume = {58},
number = {1},
pages = {2638047},
publisher = {Taylor \& Francis},
issn = {0785-3890},
doi = {10.1080/
url = {https://
pmid = {41802229},
pmcid = {PMC12973777}
}
RIS
TY - JOUR
AU - Zhang, Tongyangzi
AU - Wu, Heng
AU - Bai, Haodong
AU - Wu, Jiguang
AU - Zhang, Lili
AU - Li, Rongrong
AU - Zhu, Yiqing
AU - Sha, Bingxian
AU - Yuan, Jiaying
AU - Zhou, Yaxing
AU - Xu, Xianghuai
AU - Yu, Li
TI - Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates
T2 - Annals of medicine
J2 - Ann Med
PY - 2026
DA - 2026/
VL - 58
IS - 1
SP - 2638047
SN - 0785-3890
PB - Taylor & Francis
DO - 10.1080/
UR - https://
LA - en
ER -
CSL-JSON
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