Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study.

Overview

1. College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE
2. General Neurology, Elite Neuroscience Center, Lewisville, TX, USA
3. General Pharmacy Department, Flower Mound Pharmacy, Flower Mound, TX, USA
4. Health and Safety Department, Dubai Municipality, Dubai, UAE

Abstract

Aims: This study used an open-label design, comprising a one-arm eight-weeks-long study, and aimed to evaluate patient satisfaction and the efficacy of a novel dietary supplement composition combined with probiotic and omega-3 to support brain health improvement in 39 participants with confirmed or suspected brain fog caused by trauma, disease, exposure to chemotherapeutics, or similar events.

Methods: The primary measure was the change from baseline in survey scores of the Montreal Cognitive Assessment. The secondary outcome was the change from baseline in test scores of the self-reported survey.

Results: The results indicated significant improvements across all domains over time (p < 0.0001), with the most substantial changes occurring by Week 8. Repeated-measures analysis of variance showed a significant time effect (F [2.811, 105.4] = 43.09, p < 0.0001), suggesting that cognitive scores progressively improved across the weeks.

Conclusions: This exploratory research indicates that the trial kit was feasible, well tolerated, and associated with improvements in exploratory cognitive measures and perceived well-being over an eight-week period, although practice and placebo effects cannot be ruled out. The findings are hypothesis-generating and support further evaluations in randomized, placebo-controlled studies using well-characterized interventions, objective adherence measures, and biomarker-based outcomes.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

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Data

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• figshare:31986754, at figshare; found in DataCite

Data availability statement

The datasets generated and/or analyzed during the current study are not publicly available due to ethical and institutional restrictions but are available from the corresponding author on reasonable request.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 6 keywords, 1 funder, 31 references.

Cite

This paper

Al-Ghananeem, A. M., Cantrell, D. T. C., Song, D., & Jairoun, A. (2026). Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study. Future science OA, 12(1), 2654776. https://doi.org/10.1080/20565623.2026.2654776

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