Factors associated with drug-resistant epilepsy in adults from Southern Kazakhstan.
Overview
- Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan
- South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Abstract
Introduction: The prevalence of drug-resistant epilepsy (DRE) among epilepsy patients has not decreased despite better diagnostic methods and treatment options because it affects approximately one-third of all epilepsy patients. The research aims to identify which clinical patterns and social characteristics contribute to drug resistance.
Methods: This retrospective analytical cross-sectional study included 300 patients with epilepsy in Southern Kazakhstan. The participants received their drug resistance status through ILAE criteria, which classified them into drug-sensitive (DSE) or drug-resistant groups. Patient data was studied through clinical and socio-demographic evaluations, EEG and MRI assessments, and MoCA cognitive performance tests.
Results: The research discovered drug-resistant epilepsy in 37% of participants. The DRE patients were 35 ± 12 years old at the time of study, while DSE patients were 39 ± 15 years old (p = 0.023). The development of DRE became more likely when patients experienced their first seizure at a young age and when they had multiple seizures throughout the day (p < 0.01). The presence of MRI abnormalities increased the risk of drug resistance by 2.42 times (95% CI: 1.3–4.23) when compared to drug-sensitive epilepsy patients (p = 0.002).
Conclusion: The study revealed that early seizure onset, prolonged duration, severe seizures, brain imaging abnormalities, and lower cognitive performance are related to DRE.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Data
Datasets cited
- figshare:32132798, at figshare; found in DataCite
Data availability statement
The data that support the findings of this study are available on request from the corresponding author, N.N. The data are not publicly available due to privacy reasons.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 keywords, 1 funder, 42 references.
Cite
This paper
Baimakhanova, G., Nurdinov, N., Nuskabayeva, G., Zharkinbekova, N., Sadykova, K., Skenderova, A., Gencer, M. Z., Doszhanov, I., Yerkhojayeva, N., Anarbayeva, A., Skenderova, S., & Kaldarkhan, D. (2026). Factors associated with drug-resistant epilepsy in adults from Southern Kazakhstan. Future science OA, 12(1), 2665757. https://
BibTeX
@article{baimakhanova202
author = {Baimakhanova, Gulzira and Nurdinov, Nursultan and Nuskabayeva, Gulnaz and Zharkinbekova, Nazira and Sadykova, Karlygash and Skenderova, Akbota and Gencer, Mehmet Ziya and Doszhanov, Islamkhan and Yerkhojayeva, Nigara and Anarbayeva, Assel and Skenderova, Shakhista and Kaldarkhan, Dana},
title = {{Factors associated with drug-resistant epilepsy in adults from Southern Kazakhstan}},
journal = {Future science OA},
year = {2026},
month = apr,
volume = {12},
number = {1},
pages = {2665757},
publisher = {Taylor \& Francis},
issn = {2056-5623},
doi = {10.1080/
url = {https://
pmid = {42057682},
pmcid = {PMC13134400}
}
RIS
TY - JOUR
AU - Baimakhanova, Gulzira
AU - Nurdinov, Nursultan
AU - Nuskabayeva, Gulnaz
AU - Zharkinbekova, Nazira
AU - Sadykova, Karlygash
AU - Skenderova, Akbota
AU - Gencer, Mehmet Ziya
AU - Doszhanov, Islamkhan
AU - Yerkhojayeva, Nigara
AU - Anarbayeva, Assel
AU - Skenderova, Shakhista
AU - Kaldarkhan, Dana
TI - Factors associated with drug-resistant epilepsy in adults from Southern Kazakhstan
T2 - Future science OA
J2 - Future Sci OA
PY - 2026
DA - 2026/
VL - 12
IS - 1
SP - 2665757
SN - 2056-5623
PB - Taylor & Francis
DO - 10.1080/
UR - https://
LA - en
ER -
CSL-JSON
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