Neural correlates of emotion processing and regulation dissociate frontal and temporal lobe epilepsy.
The 1 match
- [1] § Materials and methods › Time course analysis of regions of interest › Amygdala ↔ 01-timecourse_Amygdala_HO-Atlas_allConditions.ipynb, lines 15–26 · score 0.57 · Harvard Oxford, Detrended, atlas, amygdala
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Overview
- Department of Psychology, Bielefeld University, Bielefeld 33615, Germany
- Department of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld 33617, Germany
- Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467, USA
- Department of Magnetic Resonance Imaging, Society for Epilepsy Research, Bielefeld 33617, Germany
- Center of Excellence Cognitive Interaction Technology (CITEC), Bielefeld University, Bielefeld 33615, Germany
Abstract
When confronted with negative events, regulating emotions is essential for self-management and mental health. Temporal lobe epilepsy (TLE) patients, particularly right TLE (rTLE) patients, show altered responses towards emotional stimuli. However, neural correlates of emotion regulation and its interplay with stimulus-based emotion processing have not been studied in TLE so far. Therefore, we compared functional MRI activity during up- and downregulation of emotions towards negative scenes among 21 left TLE and 18 rTLE patients, 18 frontal lobe epilepsy (FLE) patients and 17 healthy controls. To assess stimulus-based processing, participants were asked to permit their feelings towards negative or neutral pictures. Voxel-based analyses were complemented by network-based analyses, as epilepsy is a network disorder. During stimulus-based emotion processing, rTLE patients displayed less activation compared to all other groups. Regions of reduced activity were mostly part of the frontoparietal control network and the default mode network (both PFDR < 0.05) and included the frontal pole, the superior frontal gyrus, parietal regions and the cerebellum (all PFWE < 0.05). Activation patterns during emotion regulation were highly similar between controls and left TLE and rTLE patients. Direct group comparisons revealed that during upregulation of emotions, controls and left TLE patients displayed higher activity than FLE patients in areas of the left default mode network (all PFWE < 0.05). Our results dovetail with previous findings of diminished activity towards aversive stimuli in rTLE and show that in the same patients, neural underpinnings of emotion regulation are intact. In contrast, FLE patients displayed the opposite pattern with a largely intact response to aversive stimuli but disrupted neural underpinnings of emotion regulation, pointing to a double dissociation between rTLE and FLE.
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gitlab.ub.uni-bielefeld.de/ae02/emotionregulation_epilepsy
010f393812f9ba6628d3e33c73e0214e76d125d9, 9 April 2026Availability: 1 check, the latest on 27 September 2026: the link answers
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O-Atlas_allConditions.ip — Jupyter, 216 lines, 1 match, shown from its sourceynb - 01-timecourse_MarsBarClu
sters-SFG_lTLEvsFLE_upre — Jupyter, 260 lines, shown from its sourcegulateVSnegative-permit. ipynb - 01-timecourses_MarsBarCl
usters-allGroups_permit- — Jupyter, 356 lines, shown from its sourcenegativeVSpermit-neutral .ipynb - 02-timecourse-plots-Amyg
dala-allConds.ipynb — Jupyter, 1,048 lines, shown from its source - 02-timecourse-plots-Mars
BarClusters-lTLEvsFLE_up — Jupyter, 645 lines, shown from its sourceregulateVSpermit-negativ e.ipynb - 02-timecourse-plots_Mars
BarClusters-allGroups_pe — Jupyter, 1,340 lines, shown from its sourcermit-negativeVSpermit-ne utral.ipynb - MRIcroGL_betweenGroups.p
y — Python, 23 lines, shown from its source - MRIcroGL_withinGroups.py
— Python, 33 lines, shown from its source - Plot_Schaefer200_Boxplot
s_Spidercharts_cb_friend — Jupyter, 496 lines, shown from its sourcely.ipynb - extract_and_save_betas_S
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Cite
This paper
Benzait, A., Krenz, V., Wegrzyn, M., Doll, A., Woermann, F. G., Labudda, K., Bien, C. G., & Kissler, J. (2026). Neural correlates of emotion processing and regulation dissociate frontal and temporal lobe epilepsy. Brain communications, 8(4), fcag270. https://
BibTeX
@article{benzait2026neur
author = {Benzait, Anissa and Krenz, Valentina and Wegrzyn, Martin and Doll, Anna and Woermann, Friedrich G and Labudda, Kirsten and Bien, Christian G and Kissler, Johanna},
title = {{Neural correlates of emotion processing and regulation dissociate frontal and temporal lobe epilepsy}},
journal = {Brain communications},
year = {2026},
month = jul,
volume = {8},
number = {4},
pages = {fcag270},
publisher = {Oxford University Press},
issn = {2632-1297},
doi = {10.1093/
url = {https://
pmid = {42534875},
pmcid = {PMC13421894}
}
RIS
TY - JOUR
AU - Benzait, Anissa
AU - Krenz, Valentina
AU - Wegrzyn, Martin
AU - Doll, Anna
AU - Woermann, Friedrich G
AU - Labudda, Kirsten
AU - Bien, Christian G
AU - Kissler, Johanna
TI - Neural correlates of emotion processing and regulation dissociate frontal and temporal lobe epilepsy
T2 - Brain communications
J2 - Brain Commun
PY - 2026
DA - 2026/
VL - 8
IS - 4
SP - fcag270
SN - 2632-1297
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
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