Non-invasive MRI of choroid plexus vascular function.
The 2 matches
- [1] § Methods › Study 1: Choroid plexus vascular elasticity measured by hypercapnia challenge ↔ pro_CO2_CVR_DLBS_Data.m, lines 76–146 · score 0.68 · EtCO2, BOLD signal, delay, lowest, residual, linear
- [2] § Methods › Study 2: Choroid plexus vascular elasticity measured by intermittent breath modulation ↔ pro_CO2_CVR_DLBS_Data.m, lines 76–146 · score 0.55 · EtCO2, BOLD signal, linear, brain
Paper
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The authors' code
MATLAB · 210 lines · 8 KB · no license · 2 matches
pro_CO2_CVR_DLBS_Data.m at commit 22a138f, no license · at the source
Overview
- Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
- Center for Vital Longevity & Department of Psychology, The University of Texas at Dallas, Dallas, TX, United States
- Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, United States
- The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Abstract
Choroid plexus (ChP) is a highly vascularized tissue in the ventricles of the brain, and it plays an important role in the production of cerebrospinal fluid (CSF) and formation of the blood-CSF barrier. The function of ChP vessels has been implicated in waste clearance efficiency during aging and neurodegenerative diseases. At present, postmortem studies are the main method to assess choroid plexus vascular integrity, with a few tools to measure ChP function in living humans. Here, we proposed a non-invasive MRI approach to assess ChP vascular elasticity based on the detection of MRI signal changes in response to vasoactive challenges. The mechanism of the signal is hypothesized to be due to reciprocal blood and stroma volume alterations during vessel expansion. We demonstrated that ChP vascular elasticity can be evaluated with BOLD MRI using a hypercapnia challenge of CO2 inhalation. This effect is specifically located in the brain ventricles where ChP is abundant. We revealed the ability of the technique in detecting age-related reduction in ChP vascular elasticity. We further showed that this effect can be assessed with gas-free methods, including intermittent breath modulation and resting-state BOLD fMRI. We characterized the image contrast requirement under which this effect can be detected. This technique may provide a clinically feasible tool for assessing ChP vascular function in health and disease.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
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BrainPhysioMRI/ChP_elasticity
22a138f6cc646d47e6571f49b3110dc6482e46c8, 20 March 2026Availability: 1 check, the latest on 29 September 2026: the link answers
- 29 September 2026: the link answers
5 files, not copied: shown from their source
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- lib/
spm_defaults.m — MATLAB, 237 lines, shown from its source - pro_BM_relCVR_Aging_Data
.m — MATLAB, 124 lines, shown from its source - pro_CO2_CVR_DLBS_Data.m — MATLAB, 210 lines, 2 matches, shown from its source
- pro_RS_relCVR_Power_ME_D
ata.m — MATLAB, 179 lines, shown from its source - README.md — Text, 11 lines, shown from its source
The paper's code and data availability statement is in the Data section.
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Data
Datasets cited
- openfmri.org/
dataset/ — at openfmri.org; found in “Data and Code Availability”ds000258 - openneuro:ds004856 — at OpenNeuro; found in “Data and Code Availability”
- openneuro:ds007588 — at OpenNeuro; found in “Data and Code Availability”
Data and Code Availability
All data of Study 1 from the DLBS are available open access on OpenNeuro.org (https://
The codes used in this work are available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 5 authors, 6 keywords, 3 funders, 37 references.
Cite
This paper
Liu, P., Donaldson, L., Hu, B., Wig, G. S., & Lu, H. (2026). Non-invasive MRI of choroid plexus vascular function. Imaging neuroscience (Cambridge, Mass.), 4, IMAG.a.1216. https://
BibTeX
@article{liu2026non,
author = {Liu, Peiying and Donaldson, Lori and Hu, Beini and Wig, Gagan S and Lu, Hanzhang},
title = {{Non-invasive MRI of choroid plexus vascular function}},
journal = {Imaging neuroscience (Cambridge, Mass.)},
year = {2026},
month = apr,
volume = {4},
pages = {IMAG.a.1216},
publisher = {MIT Press},
issn = {2837-6056},
doi = {10.1162/
url = {https://
pmid = {42016556},
pmcid = {PMC13094013}
}
RIS
TY - JOUR
AU - Liu, Peiying
AU - Donaldson, Lori
AU - Hu, Beini
AU - Wig, Gagan S
AU - Lu, Hanzhang
TI - Non-invasive MRI of choroid plexus vascular function
T2 - Imaging neuroscience (Cambridge, Mass.)
J2 - Imaging Neurosci (Camb)
PY - 2026
DA - 2026/
VL - 4
SP - IMAG.a.1216
SN - 2837-6056
PB - MIT Press
DO - 10.1162/
UR - https://
LA - en
ER -
CSL-JSON
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