OSCR

DNA methylation signatures of treatment response in medication-overuse headache.

Overview

Authors: Katarzyna Malgorzata Kwiatkowska1, Valentina Favoni2, Francesca Ferraresi3, Chiara Pirazzini1, Francesco Ravaioli2, Maria Giulia Bacalini2,4, Daniele Dall’Olio1, Claudia Sala1,5, Gastone Castellani1,5, Luciano Calzari6, Davide Gentilini6,7, Rossana Terlizzi8, Giulia Pierangeli4, Pietro Cortelli4, Davide Mascarella2, Paolo Garagnani1,5, Sabina Cevoli2
ORCID iDs: Katarzyna Malgorzata Kwiatkowska, Francesca Ferraresi
  1. Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy
  2. IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
  3. Department of Chemistry Giacomo Ciamician, University of Bologna, 40126 Bologna, Italy
  4. Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40138 Bologna, Italy
  5. IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
  6. Bioinformatics and Statistical Genomics Unit, Istituto Auxologico Italiano IRCCS, 20095 Cusano Milanino, Milan Italy
  7. Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
  8. Department of Neurosciences, Neurology and Stroke Unit, Bufalini Hospital, AUSL Romagna, Cesena, Italy
Institutions: University of Bologna (Italy); Istituto delle Scienze Neurologiche di Bologna (Italy); IRCCS Istituto Auxologico Italiano (Italy); University of Pavia (Italy); Ospedale “M. Bufalini” di Cesena (Italy); IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (Italy)
Journal: The journal of headache and pain, volume 27, issue 1, article 100
Dates: received 26 January 2026; accepted 27 March 2026; published online 2 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s10194-026-02354-7 · PMID 41928109 · PMCID PMC13078000 · OpenAlex W7147106765
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), pain (population), clinical / translational (subfield)
Methods: Statistics
Keywords: DNA methylation, Medication overuse headache, Migraine, Chronic headache, Analgesics, Withdrawal treatment, Detox, Treatment response, Epigenetic signature, Biomarkers
MeSH: DNA Methylation*, Headache Disorders, Secondary*, Adult, Aged, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Treatment Outcome (* major topic)
Topic: Migraine and Headache Studies (Psychiatry and Mental health, Medicine), according to OpenAlex
Funding: Ministero della Salute (PE0000006)
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s10194-026-02354-7.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Funding: added Ministero della Salute: PE0000006

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 10 keywords, 11 MeSH terms, 54 references.

Cite

This paper

Kwiatkowska, K. M., Favoni, V., Ferraresi, F., Pirazzini, C., Ravaioli, F., Bacalini, M. G., Dall’Olio, D., Sala, C., Castellani, G., Calzari, L., Gentilini, D., Terlizzi, R., Pierangeli, G., Cortelli, P., Mascarella, D., Garagnani, P., & Cevoli, S. (2026). DNA methylation signatures of treatment response in medication-overuse headache. The journal of headache and pain, 27(1), 100. https://doi.org/10.1186/s10194-026-02354-7

BibTeX

@article{kwiatkowska2026dna,
author = {Kwiatkowska, Katarzyna Malgorzata and Favoni, Valentina and Ferraresi, Francesca and Pirazzini, Chiara and Ravaioli, Francesco and Bacalini, Maria Giulia and Dall’Olio, Daniele and Sala, Claudia and Castellani, Gastone and Calzari, Luciano and Gentilini, Davide and Terlizzi, Rossana and Pierangeli, Giulia and Cortelli, Pietro and Mascarella, Davide and Garagnani, Paolo and Cevoli, Sabina},
title = {{DNA methylation signatures of treatment response in medication-overuse headache}},
journal = {The journal of headache and pain},
year = {2026},
month = apr,
volume = {27},
number = {1},
pages = {100},
publisher = {BMC},
issn = {1129-2369},
doi = {10.1186/s10194-026-02354-7},
url = {https://doi.org/10.1186/s10194-026-02354-7},
pmid = {41928109},
pmcid = {PMC13078000}
}

RIS

TY - JOUR
AU - Kwiatkowska, Katarzyna Malgorzata
AU - Favoni, Valentina
AU - Ferraresi, Francesca
AU - Pirazzini, Chiara
AU - Ravaioli, Francesco
AU - Bacalini, Maria Giulia
AU - Dall’Olio, Daniele
AU - Sala, Claudia
AU - Castellani, Gastone
AU - Calzari, Luciano
AU - Gentilini, Davide
AU - Terlizzi, Rossana
AU - Pierangeli, Giulia
AU - Cortelli, Pietro
AU - Mascarella, Davide
AU - Garagnani, Paolo
AU - Cevoli, Sabina
TI - DNA methylation signatures of treatment response in medication-overuse headache
T2 - The journal of headache and pain
J2 - J Headache Pain
PY - 2026
DA - 2026/04/02
VL - 27
IS - 1
SP - 100
SN - 1129-2369
PB - BMC
DO - 10.1186/s10194-026-02354-7
UR - https://doi.org/10.1186/s10194-026-02354-7
LA - en
ER -

CSL-JSON

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