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Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development.

Overview

Authors: Maria Al Nuilati1,2, Kyungmin Kim1, Jimin Kang1,3, Min Soo Kim1,2, Uhtaek Oh1,3, Gyu-Sang Hong1,2,3
  1. Brain Science Institute, Korea Institute of Science and Technology (KIST),Seoul, 02792 Republic of Korea
  2. Division of Bio-Medical Science & Technology, University of Science and Technology KIST School,Seoul, 02792 Republic of Korea
  3. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University,Seoul, 08826 Republic of Korea
Institutions: Korea Institute of Science and Technology (South Korea); Seoul National University (South Korea)
Journal: BMC biology, volume 24, issue 1, article 133
Dates: received 18 April 2025; accepted 9 April 2026; published online 21 April 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1186/s12915-026-02604-9 · PMID 42010547 · PMCID PMC13231746 · OpenAlex W7154984300
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism)
Methods: Statistics, fMRI & imaging
Keywords: Tentonin 3, Mechanosensitive ion channel, Brain development, Embryogenesis, Mechanobiology, Neural stem cells
MeSH: Brain*, Cell Movement*, Cell Proliferation*, Membrane Proteins*, Neural Stem Cells*, Animals, Gene Expression Regulation, Developmental, Mice, Neurodevelopment (* major topic)
Topic: Cellular Mechanics and Interactions (Cell Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Research Foundation of Korea (RS-2023-00254795, RS-2024-00351160); Korea Institute of Science and Technology (26Z9011)
Citations: not cited yet (Europe PMC); 35 references in the paper

Abstract

Background: Cell fate determination during brain development, encompassing both neural stem cells (NSCs) and immature neurons, is orchestrated by complex mechanical signals. While mechanical sensing during forebrain development is gaining recognition, the underlying regulatory genes remain underexplored.

Results: In this study, we present a comprehensive analysis of the expression patterns of the mechanosensitive channel Tentonin 3 (TMEM150C, TTN3) across critical stages of embryonic brain development (E12.5, E14.5, E16.5, and E18.5) using RNAscope technology. We investigated Ttn3 expression in NSCs and immature neurons through co-staining with Nestin, Eomesodermin, and Doublecortin probes. Ttn3 transcripts were detected across multiple embryonic brain regions and layers, with a higher expression in the superficial layers compared to the ventricular and subventricular zones. In addition, we demonstrate that TTN3 is involved in the proliferation and migration of progenitor cells.

Conclusions: Our findings suggest that TTN3 may play a critical role in embryonic brain development, potentially contributing as a mechanotransduction mediator.

Supplementary Information: The online version contains supplementary material available at 10.1186/s12915-026-02604-9.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data availability

All data generated or analysed during this study are included in this published article and its supplementary information files. The datasets used and analyzed during the current study are available from the corresponding author on reasonable request. The datasets generated during the current study are included in the supplementary information files (Additional file 4).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 9 MeSH terms, 2 funders, 34 references.

Cite

This paper

Al Nuilati, M., Kim, K., Kang, J., Kim, M. S., Oh, U., & Hong, G.-S. (2026). Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development. BMC biology, 24(1), 133. https://doi.org/10.1186/s12915-026-02604-9

BibTeX

@article{alnuilati2026tentonin,
author = {Al Nuilati, Maria and Kim, Kyungmin and Kang, Jimin and Kim, Min Soo and Oh, Uhtaek and Hong, Gyu-Sang},
title = {{Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development}},
journal = {BMC biology},
year = {2026},
month = apr,
volume = {24},
number = {1},
pages = {133},
publisher = {BMC},
issn = {1741-7007},
doi = {10.1186/s12915-026-02604-9},
url = {https://doi.org/10.1186/s12915-026-02604-9},
pmid = {42010547},
pmcid = {PMC13231746}
}

RIS

TY - JOUR
AU - Al Nuilati, Maria
AU - Kim, Kyungmin
AU - Kang, Jimin
AU - Kim, Min Soo
AU - Oh, Uhtaek
AU - Hong, Gyu-Sang
TI - Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development
T2 - BMC biology
J2 - BMC Biol
PY - 2026
DA - 2026/04/21
VL - 24
IS - 1
SP - 133
SN - 1741-7007
PB - BMC
DO - 10.1186/s12915-026-02604-9
UR - https://doi.org/10.1186/s12915-026-02604-9
LA - en
ER -

CSL-JSON

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