OSCR

Neuroinflammation-associated thalamocortical functional connectivity and cognition in older adults.

Overview

Authors: Jeffrey Browndyke1,2,3, Tyler Reekes4, Mary C Wright4, Melody R Smith5, Michael Devinney4, Piper Boykin4, Vinith R Upadhya6, Daphne Zhu7, Katherine T Martucci3,4,8, Leslie M Shaw9, Teresa Waligorska9, Charlotte Herber5, Connie Tian Yu5, Henrik Zetterberg10,11,12,13,14,15,16,17, Kaj Blennow10, Janet L Huebner18, Harvey J Cohen2, Heather Whitson2, Joseph P Mathew4, Miles Berger2,3,4,5
18 affiliations
  1. Department of Psychiatry & Behavioral Sciences, Division of Behavioral Medicine & Neurosciences, Duke University Medical Center, 1830 Hillandale Road, Rm 205, Durham, NC 27705 USA
  2. Center for the Study of Aging & Human Development, Duke University Medical Center, Durham, NC USA
  3. Duke Institute for Brain Sciences, Duke University, Durham, NC USA
  4. Department of Anesthesiology, Duke University Medical Center, Durham, NC USA
  5. Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA USA
  6. Duke Trinity College of Arts & Sciences, Duke University, Durham, NC USA
  7. Duke University School of Medicine, Durham, NC USA
  8. Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC USA
  9. Department of Pathology & Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA
  10. Department of Psychiatry & Neurochemistry, Institute of Neuroscience & Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
  11. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK
  12. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
  13. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI USA
  14. Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI USA
  15. UK Dementia Research Institute at UCL, London, UK
  16. Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China
  17. Centre for Brain Research, Indian Institute of Science, Bangalore, India
  18. Duke Molecular Physiology Institute, Duke University, Durham, NC USA
Journal: Journal of neuroinflammation, volume 23, issue 1, article 312
Dates: received 9 December 2025; accepted 7 July 2026; published online 1 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03962-5 · PMID 42732056 · PMCID PMC13570534 · OpenAlex W7171958079
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: fMRI (modality), human (organism)
Methods: Spectral & time-frequency, Connectivity, Smoothing, state filtering, decompositions, Statistics, Preprocessing, fMRI & imaging, Machine learning
Keywords: Cytokine, Cerebrospinal fluid, Neuroinflammation, Brain, Thalamus, Thalamocortical, Functional connectivity, FMRI
MeSH: Aging*, Cerebral Cortex*, Cognition*, Neuroinflammatory Diseases*, Thalamus*, Aged, Aged, 80 and over, Cytokines, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Neuropsychological Tests (* major topic)
Topic: Tryptophan and brain disorders (Biological Psychiatry, Neuroscience), according to OpenAlex
Funding: Swedish Research Council ((#2023-00356, #2022-01018 and #2019-02397); NIGMS NIH HHS (T32-GM08600, T32 GM008600); NIA NIH HHS (K23 AG084898, P30 AG072958, P30-AG072958, K23AG084898); NHLBI NIH HHS (R01 HL130443, R01-HL130443)
Citations: not cited yet (Europe PMC); 98 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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  • it says that the data are available on request
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Read it in the paper: doi.org/10.1186/s12974-026-03962-5.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 8 keywords, 15 MeSH terms, 4 funders, 90 references.

Cite

This paper

Browndyke, J., Reekes, T., Wright, M. C., Smith, M. R., Devinney, M., Boykin, P., Upadhya, V. R., Zhu, D., Martucci, K. T., Shaw, L. M., Waligorska, T., Herber, C., Tian Yu, C., Zetterberg, H., Blennow, K., Huebner, J. L., Cohen, H. J., Whitson, H., Mathew, J. P., & Berger, M. (2026). Neuroinflammation-associated thalamocortical functional connectivity and cognition in older adults. Journal of neuroinflammation, 23(1), 312. https://doi.org/10.1186/s12974-026-03962-5

BibTeX

@article{browndyke2026neuroinflammation,
author = {Browndyke, Jeffrey and Reekes, Tyler and Wright, Mary C and Smith, Melody R and Devinney, Michael and Boykin, Piper and Upadhya, Vinith R and Zhu, Daphne and Martucci, Katherine T and Shaw, Leslie M and Waligorska, Teresa and Herber, Charlotte and Tian Yu, Connie and Zetterberg, Henrik and Blennow, Kaj and Huebner, Janet L and Cohen, Harvey J and Whitson, Heather and Mathew, Joseph P and Berger, Miles},
title = {{Neuroinflammation-associated thalamocortical functional connectivity and cognition in older adults}},
journal = {Journal of neuroinflammation},
year = {2026},
month = aug,
volume = {23},
number = {1},
pages = {312},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03962-5},
url = {https://doi.org/10.1186/s12974-026-03962-5},
pmid = {42732056},
pmcid = {PMC13570534}
}

RIS

TY - JOUR
AU - Browndyke, Jeffrey
AU - Reekes, Tyler
AU - Wright, Mary C
AU - Smith, Melody R
AU - Devinney, Michael
AU - Boykin, Piper
AU - Upadhya, Vinith R
AU - Zhu, Daphne
AU - Martucci, Katherine T
AU - Shaw, Leslie M
AU - Waligorska, Teresa
AU - Herber, Charlotte
AU - Tian Yu, Connie
AU - Zetterberg, Henrik
AU - Blennow, Kaj
AU - Huebner, Janet L
AU - Cohen, Harvey J
AU - Whitson, Heather
AU - Mathew, Joseph P
AU - Berger, Miles
TI - Neuroinflammation-associated thalamocortical functional connectivity and cognition in older adults
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/08/01
VL - 23
IS - 1
SP - 312
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03962-5
UR - https://doi.org/10.1186/s12974-026-03962-5
LA - en
ER -

CSL-JSON

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