Multi-stable oscillations in cortical networks with two classes of inhibition.
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Overview
Abstract
In the classical view of cortical rhythms, interactions between excitatory pyramidal neurons (E) and inhibitory parvalbumin-expressing interneurons (I) are sufficient to generate gamma- and beta-band oscillations. However, it is now well established that multiple inhibitory interneuron subtypes exist and that they play important roles in the generation and modulation of these rhythms. In this paper, we develop a spiking network model consisting of populations of E, I, and an additional interneuron type, somatostatin-expressing neurons (S), which receive excitation from the E cells and inhibit both the E and I populations. The S cells are further modulated by a third inhibitory subtype, vasoactive intestinal peptide (VIP) neurons, which receive inputs from other cortical areas. We reduce the spiking network to a system of nine differential equations that describe the mean membrane potential, firing rate, and synaptic conductance for each population. Using this reduced model, we identify a wide range of parameters that exhibit multiple coexisting rhythms. Employing tools from nonlinear dynamics, we then explore the roles of the two classes of inhibition, as well as VIP modulation, in shaping the properties of these rhythms.
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Arnabds/Comp-Neuro-Research-Project-1--Multi-stable-oscillations-in-cortical-networks-with-two-classes
9649bb15f463465640ed526c71bb35cb9d7b47ec, 27 October 2025Availability: 1 check, the latest on 27 September 2026: the link answers
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Recorded: type, language, journal, volume, issue, pages, dates, 2 authors, 11 MeSH terms, 33 references.
Cite
This paper
Dey Sarkar, A., & Ermentrout, B. (2026). Multi-stable oscillations in cortical networks with two classes of inhibition. PLoS computational biology, 22(6), e1014391. https://
BibTeX
@article{deysarkar2026mu
author = {Dey Sarkar, Arnab and Ermentrout, Bard},
title = {{Multi-stable oscillations in cortical networks with two classes of inhibition}},
journal = {PLoS computational biology},
year = {2026},
month = jun,
volume = {22},
number = {6},
pages = {e1014391},
publisher = {PLOS},
issn = {1553-734X},
doi = {10.1371/
url = {https://
pmid = {42263113},
pmcid = {PMC13298994}
}
RIS
TY - JOUR
AU - Dey Sarkar, Arnab
AU - Ermentrout, Bard
TI - Multi-stable oscillations in cortical networks with two classes of inhibition
T2 - PLoS computational biology
J2 - PLoS Comput Biol
PY - 2026
DA - 2026/
VL - 22
IS - 6
SP - e1014391
SN - 1553-734X
PB - PLOS
DO - 10.1371/
UR - https://
LA - en
ER -
CSL-JSON
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