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Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination.

Overview

Authors: Ruth Lambries1, Zihan Shen1, George I Mias1,2, Jin He1
ORCID iDs: Jin He
  1. Department of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, MI, United States
  2. Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States
Institutions: Michigan State University (United States)
Journal: Frontiers in cellular neuroscience, volume 20, article 1832157
Dates: received 16 March 2026; accepted 24 April 2026; published online 19 May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.3389/fncel.2026.1832157 · PMID 42239646 · PMCID PMC13225964 · OpenAlex W7161639895
Open access: gold, a free copy (OpenAlex)
Status: data only
Methods: Statistics, Evoked potentials, fMRI & imaging, Smoothing, state filtering, decompositions
Keywords: histone demethylase, KDM6B, myelination, neurodevelopment, oligodendrocyte
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: NIMH NIH HHS (R01 MH130544); NIGMS NIH HHS (R01 GM127431)
Citations: not cited yet (Europe PMC); 34 references in the paper

Abstract

Introduction: Postnatal cortical myelination requires epigenetic activation of oligodendrocyte gene programs, but the role of histone demethylases in vivo remains unclear.

Methods: We conditionally deleted Kdm6b in Emx1+ dorsal telencephalic progenitors and analyzed oligodendrocyte lineage progression, performed lineage-specific RNA-seq, assessed H3K27me3 occupancy by chromatin immunoprecipitation, and tested functional rescue via Sox10 induction.

Results: Kdm6b deletion delayed cortical myelination and impaired oligodendrocyte maturation without affecting precursor density. Pre-myelinating and mature oligodendrocyte markers were reduced. RNA-seq revealed early suppression of Sox10, followed by downregulation of myelin genes. Consistently, H3K27me3 enrichment increased at Sox10 regulatory regions. Sox10 induction partially rescued myelination deficits.

Discussion: These findings define a KDM6B→SOX10 axis that promotes oligodendrocyte maturation and cortical myelination by restricting repressive H3K27me3, providing mechanistic insight into epigenetic control of myelination with relevance to KDM6B-associated neurodevelopmental disorders.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

Datasets cited

Data availability statement

The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) are provided below: Gene Expression Omnibus (GEO), GSE328562 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328562).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 4 authors, 5 keywords, 2 funders, 34 references.

Cite

This paper

Lambries, R., Shen, Z., Mias, G. I., & He, J. (2026). Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination. Frontiers in cellular neuroscience, 20, 1832157. https://doi.org/10.3389/fncel.2026.1832157

BibTeX

@article{lambries2026histone,
author = {Lambries, Ruth and Shen, Zihan and Mias, George I and He, Jin},
title = {{Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination}},
journal = {Frontiers in cellular neuroscience},
year = {2026},
month = may,
volume = {20},
pages = {1832157},
publisher = {Frontiers Media SA},
issn = {1662-5102},
doi = {10.3389/fncel.2026.1832157},
url = {https://doi.org/10.3389/fncel.2026.1832157},
pmid = {42239646},
pmcid = {PMC13225964}
}

RIS

TY - JOUR
AU - Lambries, Ruth
AU - Shen, Zihan
AU - Mias, George I
AU - He, Jin
TI - Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination
T2 - Frontiers in cellular neuroscience
J2 - Front Cell Neurosci
PY - 2026
DA - 2026/05/19
VL - 20
SP - 1832157
SN - 1662-5102
PB - Frontiers Media SA
DO - 10.3389/fncel.2026.1832157
UR - https://doi.org/10.3389/fncel.2026.1832157
LA - en
ER -

CSL-JSON

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