Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification.
Overview
- School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico
- School of Medicine and Health Sciences, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico
- School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile
Abstract
Introduction: Schizophrenia is conceptualized as a disorder of brain network dysconnectivity, yet relationships between neural alterations, cognitive deficits, and genetic risk remain unclear.
Methods: We examined 86 participants: schizophrenia patients (SCZ), unaffected siblings (SCZ-SIB), healthy controls (CON), and control siblings (CON-SIB). We used a multiscale graph-theoretic analysis of task-based fMRI during N-back working memory and unsupervised clinical-cognitive clustering.
Results: We found that reduced cerebellum-sensorimotor (CER-SM) and cerebellum-cingulo-operc
Discussion: These findings demonstrate that cerebellar dysconnectivity is most detectable under moderate cognitive load, tracks with clinical state, and covaries with transdiagnostic cognitive profiles, advancing circuit-based understanding of schizophrenia heterogeneity.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- openneuro:ds000115, at OpenNeuro; found in “Data availability statement”
Data availability statement
Publicly available datasets were analyzed in this study. This data can be found here: https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 8 authors, 5 keywords, 28 references.
Cite
This paper
Rosales-Gurmendi, D. S. M., Hussain, S., de Avila-Armenta, E., Fumagal-González, G. A., Garza-Abdala, J. A., Pedro-Pérez, A. A., Toscano, J., & Tamez-Peña, J. G. (2026). Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification. Frontiers in psychiatry, 17, 1796599. https://
BibTeX
@article{rosalesgurmendi
author = {Rosales-Gurmendi, Diana S M and Hussain, Sadam and de Avila-Armenta, Eduardo and Fumagal-González, Gerardo A and Garza-Abdala, Jorge A and Pedro-Pérez, Alma A and Toscano, Jasiel and Tamez-Peña, Jose G},
title = {{Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification}},
journal = {Frontiers in psychiatry},
year = {2026},
month = apr,
volume = {17},
pages = {1796599},
publisher = {Frontiers Media SA},
issn = {1664-0640},
doi = {10.3389/
url = {https://
pmid = {42006050},
pmcid = {PMC13083132}
}
RIS
TY - JOUR
AU - Rosales-Gurmendi, Diana S M
AU - Hussain, Sadam
AU - de Avila-Armenta, Eduardo
AU - Fumagal-González, Gerardo A
AU - Garza-Abdala, Jorge A
AU - Pedro-Pérez, Alma A
AU - Toscano, Jasiel
AU - Tamez-Peña, Jose G
TI - Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification
T2 - Frontiers in psychiatry
J2 - Front Psychiatry
PY - 2026
DA - 2026/
VL - 17
SP - 1796599
SN - 1664-0640
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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