Altered functional connectivity of nucleus accumbens in patients with persistent postural-perceptual dizziness: a resting-state functional magnetic resonance imaging study.

Overview

1. Second Affiliated Hospital, Xuzhou Medical University, Xuzhou, China
2. Graduate School of Xuzhou Medical University, Xuzhou, China

Abstract

Objective: This study aimed to investigate alterations in functional connectivity (FC) of the nucleus accumbens (NAc) in patients with persistent postural-perceptual dizziness (PPPD) using resting-state functional magnetic resonance imaging (rs-fMRI), and to examine the relationship between aberrant FC and clinical characteristics.

Methods: Twenty-four patients with PPPD and 25 age and gender matched healthy controls (HCs) were enrolled. Rs-fMRI data was preprocessed using DPABI. The bilateral NAc were selected as seed regions, and seed-to-voxel FC analysis was performed. FC differences between groups were assessed using two-sample t-tests with age, sex, HAMA, and HAMD scores as covariates (voxel-level FDR-corrected q < 0.05). Correlation analysis was conducted between abnormal FC values and clinical variables.

Results: Compared with HCs, patients with PPPD exhibited significantly enhanced FC between the right NAc and the left superior occipital gyrus (Occipital_Sup_L; peak MNI: -24, -96, 24; T value = 4.35; voxel-level FDR-corrected q < 0.001), as well as between the right NAc and the right Inferior Frontal Gyrus, Orbital part (Frontal_Inf_Orb_R; peak MNI: 39, 45, -3; T value = 4.90; voxel-level FDR-corrected q < 0.001). No significant FC abnormalities were detected for the left NAc seed. Correlation analysis revealed a significant negative correlation between the FC value of right NAc to left superior occipital gyrus and disease duration in PPPD patients (r = -0.61, FDR-corrected q = 0.03).

Conclusion: Patients with PPPD exhibit enhanced FC between the right NAc and visual- and emotion-related cortical regions, including the superior occipital gyrus and orbitofrontal cortex. The negative correlation with disease duration suggests that these FC alterations may be most pronounced in the early stages of the disorder. These findings provide new insights into the neural mechanisms of visual dependence and emotional dysregulation in PPPD.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Data availability statement

The study’s material, including raw data, statistical maps, ROI masks, or analysis scripts can be shared upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 8 authors, 5 keywords, 1 funder, 34 references.

Cite

This paper

Liu, D., Shen, S., Shi, G., Zhou, W., Sun, Y., Liu, Y., Xiao, L., & Rong, L. (2026). Altered functional connectivity of nucleus accumbens in patients with persistent postural-perceptual dizziness: a resting-state functional magnetic resonance imaging study. Frontiers in psychiatry, 17, 1825054. https://doi.org/10.3389/fpsyt.2026.1825054

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1073/pnas.2601231123

Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort.

Journal: Proceedings of the National Academy of Sciences of the United States of America

In common: 3 references

[2] doi:10.1038/s41598-026-53065-7

Music-taste interactions enhance gustatory and sensorimotor brain activity.

Journal: Scientific reports

In common: fMRI, 1 reference

[3] doi:10.1093/psyrad/kkag015 [code]

Neurocomputational mechanisms of reward-based online mood regulation in adolescents with bipolar disorder and major depressive disorder.

Journal: Psychoradiology

In common: fMRI, 1 reference

[4] doi:10.1038/s41467-026-73153-6 [code]

Latent neural architecture organising shared aesthetic evaluations of visual artworks.

Journal: Nature communications

In common: fMRI, 1 reference

[5] doi:10.1162/imag.a.1213

Neural correlates of emotional memory enhancement: The role of valence and arousal.

Journal: Imaging neuroscience (Cambridge, Mass.)

In common: fMRI, 1 reference

[6] doi:10.7554/elife.107933 [code]

Modality-agnostic decoding of vision and language from fMRI.

Journal: eLife

In common: fMRI, 1 reference

[7] doi:10.1016/j.neuroimage.2026.122171 [code]

A conserved node degree-based backbone and flexible hub organization of brain connectome during naturalistic movie watching.

Journal: NeuroImage

In common: fMRI, 1 reference

[8] doi:10.1016/j.dcn.2026.101770

Neural representations of the value of helping the family during adolescence.

Journal: Developmental cognitive neuroscience

In common: fMRI, 1 reference

[9] doi:10.1038/s41467-026-72605-3 [code]

Resolving mesoscale brainstem-prefrontal-striatal pathways underlying decisions upon salient events using submillimeter-resolution fMRI.

Journal: Nature communications

In common: fMRI, 1 reference

[10] doi:10.1162/imag.a.1160 [code]

From surface to depth: Using deep learning to predict striatal fMRI reward signaling from EEG.

Journal: Imaging neuroscience (Cambridge, Mass.)

In common: fMRI, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.