Integrative In Silico Analysis of miRNA-mRNA Regulatory Networks in the Prefrontal Cortex of Individuals with Psychiatric Disorders Who Died by Suicide.
Overview
15 affiliations
- Environmental Epigenetics and Mental Health Laboratory, Faculty of Chemical Biological Sciences, Autonomous University of Campeche, Campeche 24085, Mexico; (J.L.C.-S.); (J.M.C.C.)
- Health Sciences, University of the Americas, Puebla (UDLAP), Puebla 72810, Mexico
- Research Group on Biosciences, Pedagogy, and Socio-Environmental Sciences BIOPESA, University of Tolima, Ibagué 730006, Colombia
- PhD Program in Biological Sciences, Pontificia Universidad Javeriana, Bogotá 110211, Colombia
- Animal Science and Veterinary Medicine Faculty, Universidad Nacional de Colombia, Bogotá 15372, Colombia
- Psychoimmunology Laboratory, Neuroscience Department, Ramón de la Fuente Muñiz National Institute of Psychiatry, Mexico City 14370, Mexico
- Centro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala 90062, Mexico; (M.B.-O.); (F.C.)
- Independent Researcher, Puebla 72410, Mexico
- Hospital Infantil de Tlaxcala (HIT), Tlaxcala 90606, Mexico
- Hospital Regional del ISSSTE, Puebla 72570, Mexico
- SECIHTI, LESQO Adscrito a la Benemérita Universidad Autónoma de Puebla, Puebla 72590, Mexico
- Decanato de Ciencias Médicas, Universidad Popular Autónoma del Estado de Puebla (UPAEP)-SECIHTI-Puebla, Puebla 72410, Mexico
- Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
- Multidisciplinary Laboratory in Biomedicine, Biotechnology and Integrative Bioinformatics Applied to Health (LAMB3IS), Faculty of Health Sciences, Autonomous University of Tlaxcala (UATx), Zacatelco 90750, Mexico
- Institut de Pharmacologie et de Biologie Structurale (IPBS-CNRS), 31077 Toulouse, France
Abstract
To explore the regulatory aspects of mRNAs and miRNAs in suicide, we integrated transcriptomic data from GEO datasets. The analysis of mRNA expression in the prefrontal cortex of suicide victims with major depressive disorder revealed a differential profile with 27 downregulated mRNAs, including HSPA1A, HSPA1B, DNAJB1, NR4A1, and GADD45B, which are involved in proteostasis, transcriptional regulation, and apoptosis. Functional enrichment analysis using KEGG and Gene Ontology (GO) revealed significant associations with synaptic plasticity, neuronal survival, and signaling pathways, including MAPK, TGF-β, Wnt, p53, and neurotrophins. Subsequently, using the GSE34120 GEO dataset of miRNAs from the frontal cortex of suicide victims, 105 dysregulated miRNAs were identified. The networks revealed compact regulatory modules with hsa-miR-576-3p, hsa-miR-493, and hsa-miR-550, as well as highly connected central nodes such as hsa-miR-30b, hsa-miR-16a-5p, hsa-miR-181a-5p, and hsa-miR-184. The integration of both profiles allowed the elaboration of miRNA–mRNA regulatory networks in which TP53, FOXO3, RELA, and FOS interact with multiple dysregulated miRNAs. These findings support the notion that suicide involves complex post-transcriptional dysregulation, particularly related to astrocytic function and neurotrophic signaling, with potential diagnostic and therapeutic applications.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE34120, at NCBI GEO; found in “Data Availability Statement”
Data Availability Statement
The datasets analyzed in this study are publicly available in the Gene Expression Omnibus (GEO) under accession numbers GSE34120 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 5 keywords, 13 MeSH terms, 3 funders, 77 references.
Cite
This paper
Cortéz-Sánchez, J. L., Rivera-Escobar, H. M., Muñoz Roa, E. N., Zabala-Bello, C. A., Pérez-Sánchez, G., Chin Chan, J. M., Bautista-Ortiz, M., López-Martínez, K. M., Osorio-Antonio, F., Gálvez-Romero, J. L., Carrasco Carballo, A., Sedeño-Monge, V., Castelán, F., & Bautista-Rodríguez, E. (2026). Integrative In Silico Analysis of miRNA-mRNA Regulatory Networks in the Prefrontal Cortex of Individuals with Psychiatric Disorders Who Died by Suicide. International journal of molecular sciences, 27(7), 3126. https://
BibTeX
@article{cortezsanchez20
author = {Cortéz-Sánchez, José Luis and Rivera-Escobar, Hernán Mauricio and Muñoz Roa, Esther Natalia and Zabala-Bello, Carlos Andrés and Pérez-Sánchez, Gilberto and Chin Chan, José Miguel and Bautista-Ortiz, Monserrat and López-Martínez, Karla María and Osorio-Antonio, Federico and Gálvez-Romero, José Luis and Carrasco Carballo, Alan and Sedeño-Monge, Virginia and Castelán, Francisco and Bautista-Rodríguez, Elizabeth},
title = {{Integrative In Silico Analysis of miRNA-mRNA Regulatory Networks in the Prefrontal Cortex of Individuals with Psychiatric Disorders Who Died by Suicide}},
journal = {International journal of molecular sciences},
year = {2026},
month = mar,
volume = {27},
number = {7},
pages = {3126},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {1422-0067},
doi = {10.3390/
url = {https://
pmid = {41977312},
pmcid = {PMC13073591}
}
RIS
TY - JOUR
AU - Cortéz-Sánchez, José Luis
AU - Rivera-Escobar, Hernán Mauricio
AU - Muñoz Roa, Esther Natalia
AU - Zabala-Bello, Carlos Andrés
AU - Pérez-Sánchez, Gilberto
AU - Chin Chan, José Miguel
AU - Bautista-Ortiz, Monserrat
AU - López-Martínez, Karla María
AU - Osorio-Antonio, Federico
AU - Gálvez-Romero, José Luis
AU - Carrasco Carballo, Alan
AU - Sedeño-Monge, Virginia
AU - Castelán, Francisco
AU - Bautista-Rodríguez, Elizabeth
TI - Integrative In Silico Analysis of miRNA-mRNA Regulatory Networks in the Prefrontal Cortex of Individuals with Psychiatric Disorders Who Died by Suicide
T2 - International journal of molecular sciences
J2 - Int J Mol Sci
PY - 2026
DA - 2026/
VL - 27
IS - 7
SP - 3126
SN - 1422-0067
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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