Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice.
Overview
Abstract
Motor skill learning is a complex and gradual process that involves the cortex and basal ganglia, both crucial for the acquisition and long-term retention of skills. The cerebellum, which rapidly learns to adjust the movement, connects to the motor cortex and the striatum primarily via the ventral and intralaminar thalamus, respectively. Here, we evaluated the contribution of cerebellar neurons projecting to these thalamic nuclei in a skilled locomotion task in mice. Using a targeted chemogenetic inhibition that preserves the motor abilities, we found that cerebellar nuclei neurons projecting to the intralaminar thalamus contribute to learning and expression, while cerebellar nuclei neurons projecting to the ventral thalamus contribute to offline consolidation. Asymptotic performance, however, required each type of neurons. Thus, our results show that cerebellar neurons belonging to two parallel cerebello-thalamic pathways play distinct, but complementary, roles functioning on different timescales and both necessary for motor skill learning.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- doi:10.5061/
dryad.51c59zwpw , at Dryad; found in “Data availability”
Data availability
The data is available on a Dryad repository: https://
The following dataset was generated:
VaraniA LénaC PopaD 2026Latency to fall in rotarod task for mice tested with various inhibition of cerebellar nuclei neurons and corresponding control groupsDryad Digital Repository10.5061/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 8 authors, 7 keywords, 9 MeSH terms, 2 funders, 101 references, 7 RRIDs.
Cite
This paper
Varani, A. P., Mailhes-Hamon, C., Sala, R. W., Sarraudy, M., Fouda, S., Frontera, J. L., Léna, C., & Popa, D. (2026). Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice. eLife, 13, RP102813. https://
BibTeX
@article{varani2026multi
author = {Varani, Andrés Pablo and Mailhes-Hamon, Caroline and Sala, Romain W and Sarraudy, Marie and Fouda, Sarah and Frontera, Jimena L and Léna, Clément and Popa, Daniela},
title = {{Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice}},
journal = {eLife},
year = {2026},
month = apr,
volume = {13},
pages = {RP102813},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/
url = {https://
pmid = {42017796},
pmcid = {PMC13102391}
}
RIS
TY - JOUR
AU - Varani, Andrés Pablo
AU - Mailhes-Hamon, Caroline
AU - Sala, Romain W
AU - Sarraudy, Marie
AU - Fouda, Sarah
AU - Frontera, Jimena L
AU - Léna, Clément
AU - Popa, Daniela
TI - Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/
VL - 13
SP - RP102813
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.7554/
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"title": "Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice",
"container-title": "eLife",
"author": [
{
"family": "Varani",
"given": "Andrés Pablo"
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{
"family": "Sala",
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{
"family": "Sarraudy",
"given": "Marie"
},
{
"family": "Fouda",
"given": "Sarah"
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"family": "Frontera",
"given": "Jimena L"
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"family": "Léna",
"given": "Clément"
},
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"family": "Popa",
"given": "Daniela"
}
],
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"volume": "13",
"page": "RP102813",
"DOI": "10.7554/
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"PMCID": "PMC13102391",
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"publisher": "eLife Sciences Publications, Ltd",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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