OSCR

Circadian control of a sex-specific behavior in <i>Drosophila</i>.

Overview

Authors: Sabrina Riva1, Maria Fernanda Ceriani2, Sebastián Risau-Gusman1, Diana Lorena Franco1
ORCID iDs: Sabrina Riva, Maria Fernanda Ceriani, Sebastián Risau-Gusman, Diana Lorena Franco
  1. Medical Physics Department, Bariloche Atomic Center, Comisión Nacional de Energía Atómica (CNEA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Carlos de Bariloche Argentina
  2. Laboratorio de Genética del Comportamiento. Fundación Instituto Leloir - IIBBA - CONICET Buenos Aires Argentina
Institutions: Comisión Nacional de Energía Atómica (Argentina); Fundación Instituto Leloir (Argentina)
Journal: eLife, volume 13, article RP103359
Dates: published online 18 May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.7554/elife.103359 · PMID 42148735 · PMCID PMC13183377 · OpenAlex W4405526677
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: drosophila (organism)
Methods: Statistics, Preprocessing, Connectivity, Smoothing, state filtering, decompositions
Keywords: circadian rhythm, egg-laying, neural circuits, female behavior, semiautomated device, D. melanogaster
MeSH: Circadian Clocks*, Circadian Rhythm*, Drosophila melanogaster*, Oviposition*, Sexual Behavior, Animal*, Animals, Cryptochromes, Drosophila Proteins, Female, Male, Neurons (* major topic)
Journal subjects: Neuroscience
Topic: Circadian rhythm and melatonin (Endocrine and Autonomic Systems, Neuroscience), according to OpenAlex
Funding: Agencia Nacional de Promoción Científica y Tecnológica (PICT 2016-1042, PICT2019-1015, PICT-2021-00213); Universidad Nacional del Comahue, CRUB (Grant 04/B239)
Citations: cited by 2 papers (Europe PMC); 71 references in the paper

Abstract

An endogenous circadian clock controls many of the behavioral traits of Drosophila melanogaster. This ‘clock’ relies on the activity of interconnected clusters of neurons that harbor the clock machinery. The hierarchy among clusters involved in the control of rest-activity cycles has been extensively studied. Sexually dimorphic behaviors, on the other hand, have received less attention. Even though egg-laying, a female characteristic behavior, has been shown to be rhythmic, it remains largely unexplored possibly due to methodological constraints. The current study provides the first steps towards determining the neural substrates underlying the circadian control of egg-laying. We show that, whereas the lateral ventral neurons (LNvs) and the dorsal neurons (DNs) are dispensable, the lateral dorsal neurons (LNds) are necessary for rhythmic egg-laying. Systematically probing the Drosophila connectome for contacts between circadian clusters and oviposition-related neurons, we found no evidence of direct connections between LNvs or DNs and neurons recruited during oviposition. Conversely, we did find bidirectional connections between two Cryptochrome (Cry) expressing LNd (Cry + LNds) and oviposition-related neurons. Taken together, these results reveal that Cry + LNd neurons have a leading role in the control of the egg-laying rhythm in Drosophila females.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Data availability

All data is now available at https://github.com/srisaug/flywork (copy archived at Risau-Gusman, 2026).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 4 authors, 6 keywords, 11 MeSH terms, 2 funders, 69 references.

Cite

This paper

Riva, S., Ceriani, M. F., Risau-Gusman, S., & Franco, D. L. (2026). Circadian control of a sex-specific behavior in <i>Drosophila</i>. eLife, 13, RP103359. https://doi.org/10.7554/elife.103359

BibTeX

@article{riva2026circadian,
author = {Riva, Sabrina and Ceriani, Maria Fernanda and Risau-Gusman, Sebastián and Franco, Diana Lorena},
title = {{Circadian control of a sex-specific behavior in \<i\>Drosophila\</i\>}},
journal = {eLife},
year = {2026},
month = may,
volume = {13},
pages = {RP103359},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/elife.103359},
url = {https://doi.org/10.7554/elife.103359},
pmid = {42148735},
pmcid = {PMC13183377}
}

RIS

TY - JOUR
AU - Riva, Sabrina
AU - Ceriani, Maria Fernanda
AU - Risau-Gusman, Sebastián
AU - Franco, Diana Lorena
TI - Circadian control of a sex-specific behavior in <i>Drosophila</i>
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/05/18
VL - 13
SP - RP103359
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/elife.103359
UR - https://doi.org/10.7554/elife.103359
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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