Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.
Paper
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The authors' code
MATLAB · 7 lines · 276 B · MIT
- %GC inhibition changes over days
- den_GCtoMC_days = zeros(length(den_GCtoMC),num_days+2);
- den_GCtoMC_days(:,1) = den_GCtoMC';%day -1
- tar_den = flip(den_GCtoMC);
- for i=1:length(den_GCtoMC)
- den_GCtoMC_days(i,2:end) = linspace(den_GCtoMC(i),tar_den(i),num_days+1);
- end
Chang_den_GC2MC.m at commit 472d5a1, under MIT · at the source
Overview
- Department of Brain and Cognitive Sciences, University of Rochester Rochester United States
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry Rochester United States
Abstract
In the olfactory system, adult-neurogenesis results in the continuous reorganization of synaptic connections and network architecture throughout the animal’s life. This poses a critical challenge: How does the olfactory system maintain stable representations of odors amidst this ongoing circuit instability? Utilizing a detailed spiking network model of early olfactory circuits, we uncovered dual roles for adult-neurogenesis: one that both supports representational stability to faithfully encode odor information, and also one that facilitates plasticity to allow for learning and adaptation. In the main olfactory bulb, adult-neurogenesis affects neural codes in individual mitral and tufted cells but preserves odor representations at the neuronal population level. By contrast, in the olfactory piriform cortex (PCx), both individual cell responses and overall population dynamics undergo progressive changes due to adult-neurogenesis. This leads to representational drift, a gradual alteration in stimulus-evoked activity patterns. Both processes are dynamic and depend on experience such that repeated exposure to specific odors reduces the drift due to adult-neurogenesis; thus, when the odor environment is stable over the course of adult-neurogenesis, it is spike-timing-dependent plasticity that leads representations to remain stable in the PCx; when those olfactory environments change, adult-neurogenesis allows cortical representations to track environmental change. Whereas perceptual stability and plasticity due to learning are often thought of as two distinct, often contradictory processes in neuronal coding, we find that adult-neurogenesis serves as a shared mechanism for both. In this regard, the quixotic presence of adult-neurogenesis in the mammalian olfactory bulb that has been the focus of considerable investigation in chemosensory neuroscience may be the mechanistic underpinning behind an array of complex computations.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
Its files are read in the Code ↔ Paper reader above.
MAGICzhen/neurogenesis_model
472d5a19f63027b98bddfb511c13d8ac837d306b, 8 May 2026Availability: 1 check, the latest on 28 September 2026: the link answers
- 28 September 2026: the link answers
11 files
- Chang_den_GC2MC.m, MATLAB, 7 lines
- Define_odors.m, MATLAB, 48 lines
- GC_Group_divide.m, MATLAB, 11 lines
- GC_replace_New.m, MATLAB, 25 lines
- Latency_corr_plt.m, MATLAB, 29 lines
- MC_PC_Group_divide.m, MATLAB, 35 lines
- Magnitude_corr_plt.m, MATLAB, 27 lines
- Main.m, MATLAB, 47 lines
- Simulate_network_respons
es.m , MATLAB, 241 lines - LICENSE, License, 21 lines
- README.md, Text, 4 lines
The paper's code and data availability statement is in the Data section.
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Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
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Data
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Data availability
The current manuscript is a computational study, so no data have been generated for this manuscript. All source code is provided in GitHub (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 2 authors, 6 keywords, 8 MeSH terms, 6 funders, 114 references.
Cite
This paper
Chen, Z., & Padmanabhan, K. (2026). Adult-neurogenesis allows for representational stability and flexibility in early olfactory system. eLife, 14, RP107905. https://
BibTeX
@article{chen2026adult,
author = {Chen, Zhen and Padmanabhan, Krishnan},
title = {{Adult-neurogenesis allows for representational stability and flexibility in early olfactory system}},
journal = {eLife},
year = {2026},
month = may,
volume = {14},
pages = {RP107905},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/
url = {https://
pmid = {42112574},
pmcid = {PMC13160554}
}
RIS
TY - JOUR
AU - Chen, Zhen
AU - Padmanabhan, Krishnan
TI - Adult-neurogenesis allows for representational stability and flexibility in early olfactory system
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/
VL - 14
SP - RP107905
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/
UR - https://
LA - en
ER -
CSL-JSON
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"title": "Adult-neurogenesis allows for representational stability and flexibility in early olfactory system",
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"volume": "14",
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"DOI": "10.7554/
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"ISSN": "2050-084X",
"publisher": "eLife Sciences Publications, Ltd",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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}
}
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