A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory.

Overview

1. Department of Public Health Sciences, The University of Chicago Chicago United States
2. Department of Neurology, The University of Chicago Chicago United States

Abstract

Episodic memory is critically dependent on the hippocampal network and is frequently impaired in many clinical disorders. Recent findings highlight Hippocampal Indirectly Targeted Stimulation (HITS) as a promising, network-guided non-invasive transcranial magnetic stimulation (TMS) procedure to enhance episodic memory performance. Here, we report the first comprehensive meta-analysis of HITS effects on episodic memory, encompassing both healthy individuals and clinical populations. HITS using parieto-occipital network targets robustly improved episodic memory, with effects selective for episodic memory versus other non-memory cognitive domains. Efficacy was significantly greater when memory performance was assessed using memory tasks sensitive to recollection, which is strongly linked to hippocampal network function, compared to recognition or other types of episodic memory tasks. Efficacy was also significantly greater when HITS was delivered before the memory tasks were administered versus in the period between study and test phases of tasks. No serious adverse events were reported. These findings establish HITS as a robust approach for episodic memory enhancement, suggesting potential for clinical translation in memory disorders. Selectivity of effects for episodic memory generally and for recollection-format tests in particular indicates cognitive and mechanistic specificity, supporting the potential for targeted and selective neuromodulation of hippocampal networks and their associated functions.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

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Data availability

A table of standardized effect sizes categorized by study and by the factor categories to which they were assigned for analysis, along with analysis code for reproducing findings are deposited in Dryad (datadryad.org), available for download at: https://doi.org/10.5061/dryad.vhhmgqp86.

The following dataset was generated:

Badillo GoicoecheaE AgresP RauJ San AgustínA VossJL 2026Data and code from: A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memoryDryad Digital Repository10.5061/dryad.vhhmgqp86PMC1317557542132124

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 5 authors, 6 keywords, 5 MeSH terms, 62 references.

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This paper

Badillo Goicoechea, E., Agres, P. F., Rau, J. M., San Agustin, A., & Voss, J. L. (2026). A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory. eLife, 14, RP108934. https://doi.org/10.7554/elife.108934

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