Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects.

Overview

1. Friedrich Miescher Institute for Biomedical Research Basel Switzerland
2. Center for Medical Image Analysis and Navigation, Department of Biomedical Engineering, University of Basel Basel Switzerland
3. Faculty of Science, University of Basel Basel Switzerland

Abstract

Likely the strongest predictor of visual feedback is self-motion. In mice, the coupling between movement and visual feedback is learned with first visual experience of the world, and brief perturbations of the coupling result in strong visuomotor mismatch responses in visual cortex that possibly reflect prediction errors. In humans, predictive coding has primarily been studied using oddball paradigms, which rely on violations of stimulus probability based on recent sensory history. It was still unclear, however, whether humans exhibit visuomotor mismatch responses similar to those observed in mice. This question was important for two reasons. First, visuomotor mismatch responses in humans constitute a basis to start translating the mechanistic understanding of the circuit that computes these responses from mouse to human cortex. Second, a paradigm that can trigger strong prediction error responses and consequently requires shorter recording times would simplify experiments in a clinical setting. Here, by combining a wireless EEG recording system with a virtual reality headset, we found robust visuomotor mismatch responses in human cortex that were characterized by a reversed polarity relative to visual-evoked responses and a greater signal power than both visual responses and oddball mismatch responses.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Data availability

All data generated and analyzed during this study, along with the code used for analysis, have been uploaded to Zenodo with the URL: https://zenodo.org/records/21838550.

The following dataset was generated:

SolygaM ZelechowskiM KellerG Zenodo2026Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects10.5281/zenodo.21838550PMC1349312342623255

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 3 authors, 5 keywords, 11 MeSH terms, 3 funders, 54 references, 1 RRID.

Cite

This paper

Solyga, M., Zelechowski, M., & Keller, G. B. (2026). Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects. eLife, 14, RP108941. https://doi.org/10.7554/elife.108941

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