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How Neuromorphic Microstructures Control In Vitro Early-Stage Neuronal Outgrowth.

Code ↔ Paper

3 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 3 matches
  1. [1] § Experimental Section › Image Processing and Analysis › Analysis of Neurites Outgrowth ↔ preprocessing_bulk_vids.py, lines 881–941 · score 0.70 · distance matrix, custom distance, pairwise, DBSCAN, vector, pillar
  2. [2] § Experimental Section › Image Processing and Analysis › Analysis of Neurites Outgrowth ↔ post_processing_data_analysis_singlecsv.py, lines 398–483 · score 0.66 · movement dynamics, DataFrame, conversion factor, median, displacements, min
  3. [3] § Experimental Section › Image Processing and Analysis › Analysis of Neurites Outgrowth ↔ preprocessing_bulk_vids.py, lines 480–521 · score 0.56 · instantaneous velocities, vector, interval, displacements, min, Centroid

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

Python · 1,596 lines · 74 KB · no license · 2 matches

The registry keeps no copy of this file: its repository has no license, so its authors keep all their rights to it. Your browser shows it from its source, with JavaScript.

It can be read at the source: preprocessing_bulk_vids.py.

Overview

Authors: Claudia Latte Bovio1,2, Esther Matamoros3,4, Valentina Mollo1, Anna Mariano1, Valeria Criscuolo3,4, Francesca Santoro1,3,4
  1. Tissue Electronics, Istituto Italiano di Tecnologia, Naples, Italy
  2. Dipartimento di Chimica, Materiali e Produzione Industriale, Università di Napoli Federico II, Naples, Italy
  3. Neuroelectronic Interfaces, Faculty of Electrical Engineering and IT, RWTH Aachen, Aachen, Germany
  4. Institute for Biological Information Processing‐Bioelectronics (IBI‐3), Forschungszentrum Juelich, Juelich, Germany
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany), volume 13, issue 33, article e10822
Dates: received 18 June 2025; accepted 14 January 2026; published online 19 May 2026; in print June 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/advs.202510822 · PMID 42154454 · PMCID PMC13271619 · OpenAlex W7161726734
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: optical imaging (calcium, voltage, 2-photon) (modality), human (organism)
Methods: Statistics, Preprocessing, Graphs, fMRI & imaging
Keywords: artificial spines, early‐stage neuronal interfacing, neuromorphic biomaterials, neuronal polarity and guidance, two‐photon polymerization
MeSH: Biomimetic Materials*, Biomimetics*, Neuronal Outgrowth*, Neurons*, Tissue Engineering*, Animals, Biocompatible Materials, Humans, Neurodevelopment (* major topic)
Topic: Advanced Materials and Mechanics (Mechanical Engineering, Engineering), according to OpenAlex
Citations: cited by 1 paper (Europe PMC); 73 references in the paper

Abstract

Neuromorphic biomaterials represent a novel class of materials designed to replicate the architecture and functionality of neuronal structures, offering new opportunities in tissue engineering and bioelectronics. By mimicking the complex microenvironment of native neural tissue, biomimetic microstructures provide physical scaffolding to support and guide neuronal processes, with potential applications in chip‐based platforms for monitoring and stimulating neuronal networks. However, achieving precise control over the morphology of neuromorphic materials and understanding their influence on early‐stage neuronal development are remaining challenges. In this study, we present biomimetic microstructure arrays, fabricated via two‐photon polymerization, that emulate the diverse morphologies and spatial arrangements of dendritic spines. These structures enable the investigation of neuronal responses at the early developmental stage, focusing on key processes such as cell adhesion, neuronal polarity, growth cone dynamics, and network formation.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above, with 3 matches between paragraphs and lines of code.

CHARLESProtocol2/Neurite-Growth-Analysis-Toolkit

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Commit: 9389c9a0d7707c3c47207ccda66ad36310333fd5, 26 November 2025
Languages: Python (7)
Size: 8 files, 7 scripts
Software Heritage: not archived
Found in: the text, “Analysis of Neurites Outgrowth”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: NumPy (7 files), Matplotlib (6 files), pandas (5 files), SciPy (4 files), OpenCV (3 files), seaborn (3 files), scikit-learn (2 files), Pillow (1 file), Plotly (1 file), scikit-image (1 file), statsmodels (1 file)
Availability: 1 check, the latest on 28 September 2026: the link answers
  • 28 September 2026: the link answers
8 files, not copied: shown from their source

OSCR keeps no copy of these files: this repository has no license that allows it. The reader above shows each one from its source, fetched by your browser at commit 9389c9a, when its fingerprint is the one OSCR verified. How this works.

EstherMatamoros/ProteinExpression

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Commit: 1f3196f1d7c8c4d3dea63eb37b9d3b945402aa6c, 10 September 2024
Languages: Python (2)
Size: 3 files, 2 scripts
Software Heritage: not archived
Found in: the text, “Cell Adhesion”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: Matplotlib (2 files), pandas (2 files), NumPy (1 file), OpenCV (1 file), scikit-image (1 file), SciPy (1 file), seaborn (1 file)
Availability: 1 check, the latest on 28 September 2026: the link answers
  • 28 September 2026: the link answers
3 files, not copied: shown from their source

OSCR keeps no copy of these files: this repository has no license that allows it. The reader above shows each one from its source, fetched by your browser at commit 1f3196f, when its fingerprint is the one OSCR verified. How this works.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 9 scripts, each with its path and the digest of its content;
  • 3 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 5 keywords, 9 MeSH terms, 57 references.

Cite

This paper

Latte Bovio, C., Matamoros, E., Mollo, V., Mariano, A., Criscuolo, V., & Santoro, F. (2026). How Neuromorphic Microstructures Control In Vitro Early-Stage Neuronal Outgrowth. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 13(33), e10822. https://doi.org/10.1002/advs.202510822

BibTeX

@article{lattebovio2026how,
author = {Latte Bovio, Claudia and Matamoros, Esther and Mollo, Valentina and Mariano, Anna and Criscuolo, Valeria and Santoro, Francesca},
title = {{How Neuromorphic Microstructures Control In Vitro Early-Stage Neuronal Outgrowth}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = may,
volume = {13},
number = {33},
pages = {e10822},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/advs.202510822},
url = {https://doi.org/10.1002/advs.202510822},
pmid = {42154454},
pmcid = {PMC13271619}
}

RIS

TY - JOUR
AU - Latte Bovio, Claudia
AU - Matamoros, Esther
AU - Mollo, Valentina
AU - Mariano, Anna
AU - Criscuolo, Valeria
AU - Santoro, Francesca
TI - How Neuromorphic Microstructures Control In Vitro Early-Stage Neuronal Outgrowth
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/05/19
VL - 13
IS - 33
SP - e10822
SN - 2198-3844
PB - Wiley
DO - 10.1002/advs.202510822
UR - https://doi.org/10.1002/advs.202510822
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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