A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.
Overview
- Department of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
- Lingang Laboratory, Shanghai, China
Abstract
Trigeminal neuralgia (TN) is widely recognized to be one of the most severe pain disorders, severely affects the life quality of patients. However, the neuronal mechanisms underlying TN pathogenesis remain largely unknown. Here, we identify a periphery‐to‐brain neural circuit that governs TN development in mice. Tachykinin 1 (Tac1)‐expressing parabrachial nucleus (PBNTac1) neurons show heightened stimulus‐evoked responses, and chemogenetic inhibition of these neurons effectively prevents TN development. Furthermore, PBNTac1 neurons receive projections from the caudal part of the spinal trigeminal nucleus (Sp5C), and PBN‐projecting Sp5C neurons are essential for TN‐induced pain hypersensitivity. Remarkably, PBN‐projecting Sp5C neurons predominantly express Tac1, and knockdown Tac1 gene in these neurons significantly attenuates TN‐induced pain hypersensitivity. Through retrograde viral tracing and electrophysiological recordings, we demonstrate that Tac1‐expressing Sp5C neurons directly relay signals from the trigeminal ganglion (TG) to the PBN. Collectively, our findings unveil a critical TG‐Sp5CTac1‐PBNTac1 pathway that drives the TN pathogenesis.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE322600, at NCBI GEO; found in “Data Availability Statement”
Data Availability Statement
Single‐neuron sequencing datasets generated in the current study are available in the GSE322600 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 7 keywords, 11 MeSH terms, 2 funders, 82 references, 12 RRIDs.
Cite
This paper
Sun, L., Wang, J., Li, X., Lin, X., Li, J., Yu, Q., Wang, Z., Gao, X., Jin, L., Li, W., Cheng, T., & Deng, J. (2026). A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 13(29), e16310. https://
BibTeX
@article{sun2026tac1,
author = {Sun, Liting and Wang, Jia‐Jia and Li, Xiang‐Yu and Lin, Xin‐Yi and Li, Juan and Yu, Qiu‐Tong and Wang, Zi‐Han and Gao, Xue‐Ping and Jin, Lei and Li, Wei‐Ke and Cheng, Tian‐Lin and Deng, Juan},
title = {{A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = mar,
volume = {13},
number = {29},
pages = {e16310},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/
url = {https://
pmid = {41824792},
pmcid = {PMC13205611}
}
RIS
TY - JOUR
AU - Sun, Liting
AU - Wang, Jia‐Jia
AU - Li, Xiang‐Yu
AU - Lin, Xin‐Yi
AU - Li, Juan
AU - Yu, Qiu‐Tong
AU - Wang, Zi‐Han
AU - Gao, Xue‐Ping
AU - Jin, Lei
AU - Li, Wei‐Ke
AU - Cheng, Tian‐Lin
AU - Deng, Juan
TI - A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/
VL - 13
IS - 29
SP - e16310
SN - 2198-3844
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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