Experience-Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization.
Overview
- Key Laboratory of Molecular Medicine and Biotherapy School of Life Science Beijing Institute of Technology Beijing China
- Department of Biology Shenzhen MSU‐BIT University Shenzhen Guangdong China
- The First Hospital of Hebei Medical University Shijiazhuang Hebei China
Abstract
Memory generalization is essential for adaption to novel circumstances through experiential learning, leading to behavioral flexibility and survival capability. However, its underlying neural mechanisms remain to be elucidated. This study designed 8‐arm‐maze‐based tasks to reveal how the hippocampal CA3 associates with the generalization of spatial working memory. Mice successfully transferred the learned rule to novel task configurations, but the efficiency was inversely correlated with task difficulty. In vivo electrophysiological recordings of the CA3 showed that single‐unit and population activity in the CA3 reflected this behavioral transition. On testing day 1, neuronal firing and population trajectories robustly distinguished in relatively simple tasks, but not in more difficult tasks. On testing day 2, as behavioral performance improved, the representational differences of the CA3 neuronal population across different tasks gradually decreased. Decoding analysis revealed that task discriminability based on population activity decreased over time, indicating CA3 neural coding is shifting toward a more generalized pattern. Feature elimination analysis further demonstrated that CA3 neurons employ a sparse but redundant coding scheme to support generalization. Together, the observed neural and behavioral changes are consistent with the emergence of generalized task representations, indicating experience‐dependent reorganization of CA3 population activity during memory generalization across task configurations.
Reproduced under the paper's license (CC BY), from the paper cited above.
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All data reported in this paper will be shared by the lead contact upon request. Any additional information required to reanalyze the data reported in this paper is available from the corresponding authors upon request.
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Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, pages, dates, 9 authors, 4 keywords, 7 funders, 41 references.
Cite
This paper
Song, D., Zhu, Z., Deng, Y., Song, Y., Li, H., Ni, J., Quan, Z., Yan, Y., & Qing, H. (2026). Experience-Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e76661. https://
BibTeX
@article{song2026experie
author = {Song, Da and Zhu, Zilu and Deng, Yujun and Song, Yujie and Li, Hui and Ni, Junjun and Quan, Zhenzhen and Yan, Yan and Qing, Hong},
title = {{Experience-Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = jul,
pages = {e76661},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/
url = {https://
pmid = {42467954},
pmcid = {PMC13379258}
}
RIS
TY - JOUR
AU - Song, Da
AU - Zhu, Zilu
AU - Deng, Yujun
AU - Song, Yujie
AU - Li, Hui
AU - Ni, Junjun
AU - Quan, Zhenzhen
AU - Yan, Yan
AU - Qing, Hong
TI - Experience-Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/
SP - e76661
SN - 2198-3844
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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"container-title": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
"author": [
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"URL": "https://
"language": "en",
"issued": {
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}
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