Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain.
Overview
- Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, China
- Department of Pathophysiology, Hebei Key Laboratory of Critical Disease Mechanism and Intervention, Hebei Medical University, Shijiazhuang, China
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China
- Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China
- College of Pharmaceutical Sciences, Hebei University, Baoding, China
- Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Abstract
Postoperative pain impairs patients’ quality of life. Mechanisms underlying postoperative pain remain incompletely understood. We investigated postoperative pain in a mouse model of skin plus deep tissue incision (INC). We found Cxcl5 was among the top upregulated genes in incision site, which was produced from both incised skin and muscle. Single‐cell RNA‐sequencing reveals elevated human CXCL5 gene expression in human skin wounds. Neutralizing CXCL5 abrogated INC pain. Global knockout of CXCL5 receptor CXCR2 improved INC pain, but markedly delayed wound healing. Cxcr2 conditional knockout in nociceptive sensory neurons improved INC pain without affecting wound healing and local inflammation. CXCR2 expression and its coupling with TRPA1 were enhanced in DRG neurons innervating the incised site, resulting in neuron hyperexcitability upon CXCL5 stimulation. CXCL5 further enhances TRPV1 activity via neuronal CXCR2‐mediated signaling in DRG neurons innervating the incised site. Neuronal CXCR2‐mediated TRPV1/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE255436, at NCBI GEO; found in the text, “CXCL5 Signals Through Neuronal CXCR2 to…”
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, pages, dates, 11 authors, 5 keywords, 4 funders, 62 references.
Cite
This paper
Pan, Y., Li, P., Chen, Y., Dong, Z., Li, Y., Liu, B., Tai, Y., Wang, C., Fang, J., Yin, C., & Liu, B. (2026). Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e77085. https://
BibTeX
@article{pan2026targetin
author = {Pan, Yushuang and Li, Peiyi and Chen, Yufeng and Dong, Zishan and Li, Yuanyuan and Liu, Boyu and Tai, Yan and Wang, Chuan and Fang, Jianqiao and Yin, Chengyu and Liu, Boyi},
title = {{Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = aug,
pages = {e77085},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/
url = {https://
pmid = {42579274},
pmcid = {PMC13460279}
}
RIS
TY - JOUR
AU - Pan, Yushuang
AU - Li, Peiyi
AU - Chen, Yufeng
AU - Dong, Zishan
AU - Li, Yuanyuan
AU - Liu, Boyu
AU - Tai, Yan
AU - Wang, Chuan
AU - Fang, Jianqiao
AU - Yin, Chengyu
AU - Liu, Boyi
TI - Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/
SP - e77085
SN - 2198-3844
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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